• 1. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 2. An analysis of the WTC fires using CIB correlations and simple modeling
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• 3. Alternative synthesis of the anti-baldness compound RU58841?
  RSC Adv., 2014,4, 14143-14148
• 4. An ion-gating multinanochannel system based on a copper-responsive self-cleaving DNAzyme?
  Yang Chen,Di Zhou,Zheyi Meng,Jin Zhai Chem. Commun., 2016,52, 10020-10023
• 5. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003

Pyridazine-3-carbonitrile (CAS No. 53896-49-4): A Versatile Intermediate in Modern Chemical Synthesis

Pyridazine-3-carbonitrile, a compound with the chemical formula C?H?N? and the CAS number 53896-49-4, has emerged as a critical intermediate in the field of organic synthesis and pharmaceutical development. This heterocyclic compound, featuring a six-membered ring with two nitrogen atoms at positions 1 and 4, and a nitrile group at position 3, exhibits unique chemical properties that make it invaluable for constructing complex molecular architectures.

The structural motif of Pyridazine-3-carbonitrile (Pyridazine-3-carbonitrile) provides a rich platform for functionalization, enabling chemists to access a wide array of derivatives with tailored biological activities. The nitrile group, in particular, serves as a versatile handle for further transformations, including hydrolysis to carboxylic acids, reduction to amides, or condensation reactions to form cyclic compounds. These transformations are fundamental in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals.

In recent years, Pyridazine-3-carbonitrile has garnered significant attention in the pharmaceutical industry due to its role as a precursor in the development of novel therapeutic agents. The compound's ability to serve as a scaffold for drug discovery has been leveraged in the design of molecules targeting various diseases. For instance, derivatives of Pyridazine-3-carbonitrile have shown promise in inhibiting enzymes associated with inflammatory responses and metabolic disorders. The structural flexibility offered by this heterocycle allows for the optimization of pharmacokinetic and pharmacodynamic properties, making it an attractive building block for medicinal chemists.

One of the most compelling aspects of Pyridazine-3-carbonitrile is its utility in cross-coupling reactions, which are pivotal in modern synthetic chemistry. The nitrile group can participate in palladium-catalyzed reactions such as Suzuki-Miyaura coupling, Heck reaction, and Buchwald-Hartwig amination. These reactions enable the introduction of aryl, vinyl, and amino groups into the molecule, expanding its structural diversity. Such modifications are essential for fine-tuning the biological activity of drug candidates and developing compounds with improved efficacy and reduced side effects.

The synthesis of Pyridazine-3-carbonitrile (Pyridazine-3-carbonitrile) typically involves multi-step processes that require careful optimization to ensure high yield and purity. Common synthetic routes include cyclization reactions of hydrazine derivatives with nitriles or carbonyl compounds under controlled conditions. Advances in catalytic systems have enabled more efficient and sustainable methods for its preparation, aligning with the growing emphasis on green chemistry principles. These innovations not only improve the practicality of producing Pyridazine-3-carbonitrile but also contribute to reducing the environmental impact of its synthesis.

In academic research, Pyridazine-3-carbonitrile has been employed as a model compound to study electronic properties and reactivity patterns of heterocyclic systems. Its conjugated system and electron-withdrawing nitrile group make it an interesting candidate for exploring charge transfer processes and photochemical reactions. Such studies contribute to fundamental understanding in chemistry and may inspire new applications beyond traditional pharmaceuticals.

The role of computational chemistry in designing derivatives of Pyridazine-3-carbonitrile cannot be overstated. Molecular modeling techniques allow researchers to predict the behavior of this compound and its derivatives before conducting experimental work. This approach accelerates drug discovery pipelines by identifying promising candidates with optimal properties based on their electronic structure and molecular interactions. The integration of computational methods with experimental validation has become standard practice in modern medicinal chemistry.

As interest in bioactive heterocycles continues to grow, Pyridazine-3-carbonitrile remains at the forefront of chemical innovation. Its unique structural features offer unparalleled opportunities for designing molecules with specific biological functions. Whether used as a starting material or an intermediate, this compound exemplifies the power of heterocyclic chemistry in addressing complex challenges in medicine and industry.

The future prospects for Pyridazine-3-carbonitrile (Pyridazine-3-carbonitrile) are bright, with ongoing research exploring new synthetic pathways and applications. The continued development of this versatile intermediate will undoubtedly contribute to advancements across multiple scientific disciplines, reinforcing its importance as a cornerstone of modern chemical synthesis.

• 36650-74-5(1H-Pyrazole-3-carbonitrile)
• 1333319-50-8(5-Methylpyridazine-3-carbonitrile)
• 49840-90-6(6-Methylpyridazine-3-carbonitrile)
• 7694-81-7(1-Phthalazinecarbonitrile)
• 7694-95-3(1,4-Phthalazinedicarbonitrile)
• 1632-74-2(3,6-Dimethylpyridazine)
• 350505-39-4(3,6-Pyridazinedicarbonitrile)
• 38693-82-2(5-Methyl-1H-pyrazole-3-carbonitrile)
• 1632-76-4(3-Methylpyridazine)
• 33064-34-5(1h-pyrazole-3-carbonitrile)