• 1. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 2. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
• 3. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 4. An arsenic trioxide nanoparticle prodrug (ATONP) potentiates a therapeutic effect on an aggressive hepatocellular carcinoma model via enhancement of intratumoral arsenic accumulation and disturbance of the tumor microenvironment?
  Xin Fu,Qing-rong Liang,Rong-guang Luo,Yan-shu Li,Xiao-ping Xiao,Lu-lu Yu,Wen-zhe Shan,Guang-qin Fan J. Mater. Chem. B, 2019,7, 3088-3099
• 5. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl halides Benzyl chlorides

Comprehensive Overview of 1-(Chloromethyl)-2,4,5-trimethoxybenzene (CAS No. 53811-44-2)

1-(Chloromethyl)-2,4,5-trimethoxybenzene (CAS No. 53811-44-2) is a specialized organic compound widely utilized in pharmaceutical intermediates, agrochemical synthesis, and fine chemical applications. Its unique structural features, including the chloromethyl group and three methoxy substituents, make it a versatile building block for synthesizing complex molecules. Researchers and industries value this compound for its reactivity and adaptability in multistep organic synthesis, particularly in constructing heterocyclic frameworks.

In recent years, the demand for high-purity 1-(chloromethyl)-2,4,5-trimethoxybenzene has surged due to its role in developing bioactive compounds. A trending topic in scientific forums revolves around its application in green chemistry protocols, where solvent-free reactions and catalytic methods are explored to minimize environmental impact. This aligns with the global push toward sustainable chemical manufacturing, a frequently searched term in academic and industrial databases.

The compound’s CAS No. 53811-44-2 is often cross-referenced in patents related to drug discovery and material science. For instance, its derivatives have been investigated for potential use in photovoltaic materials, a hot topic given the rise of renewable energy technologies. Analytical techniques like HPLC and NMR are critical for quality control, as purity directly impacts downstream applications—a concern frequently raised in QA/QC discussions among chemists.

Another area of interest is the compound’s stability under varying storage conditions. Searches for "handling aromatic chloromethyl derivatives" have increased, reflecting user concerns about optimal temperature and humidity ranges. Best practices recommend inert atmospheres and moisture-resistant packaging to preserve its reactivity, a detail often highlighted in technical datasheets.

From a synthetic perspective, 1-(chloromethyl)-2,4,5-trimethoxybenzene serves as a precursor for functionalized aromatics. Its electrophilic character allows nucleophilic substitutions, enabling modifications tailored to target molecules. This flexibility is crucial for custom synthesis projects, a growing niche in contract research organizations (CROs).

In summary, CAS No. 53811-44-2 represents a critical intersection of innovation and practicality in modern chemistry. Its applications span life sciences, energy research, and industrial catalysis, making it a compound of enduring relevance. As industries prioritize efficiency and sustainability, this molecule’s role is poised to expand further.

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