• 1. Molecular modelling of compounds used for corrosion inhibition studies: a review
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• 2. Ester as a blocking group for palladium-catalysed direct forced arylation at the unfavourable site of heteroaromatics: simple access to the less accessible regioisomers
  Lu Chen,Christian Bruneau,Pierre H. Dixneuf,Henri Doucet Green Chem. 2012 14 1111
• 3. Synthesis and amide imidic prototropic tautomerization in thiophene-2-carbohydrazide: XRD, DFT/HSA-computation, DNA-docking, TG and isoconversional kinetics via FWO and KAS models
  Nabil Al-Zaqri,Tamer Khatib,Ali Alsalme,Fahad A. Alharthi,Abdelkader Zarrouk,Ismail Warad RSC Adv. 2020 10 2037
• 4. Strategic design and synthesis of star-shaped organic linkers for mesoporous MOFs
  Rosa Fucci,Christophe M. L. Vande Velde Faraday Discuss. 2021 231 97
• 5. Oxalic acid as the in situ carbon monoxide generator in palladium-catalyzed hydroxycarbonylation of arylhalides
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Thiophenes Thiophene carboxylic acids and derivatives

Recent Advances in the Application of Methyl Thiophene-2-carboxylate (CAS: 5380-42-7) in Chemical Biology and Pharmaceutical Research

Methyl thiophene-2-carboxylate (CAS: 5380-42-7) is a versatile heterocyclic compound that has garnered significant attention in recent years due to its potential applications in chemical biology and pharmaceutical research. This compound, characterized by a thiophene ring esterified with a methyl group, serves as a key intermediate in the synthesis of various bioactive molecules. Recent studies have explored its utility in drug discovery, material science, and agrochemical development, highlighting its broad applicability and promising future.

One of the most notable advancements involves the use of Methyl thiophene-2-carboxylate as a building block in the synthesis of novel kinase inhibitors. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its efficacy in the development of selective inhibitors targeting tyrosine kinases, which are implicated in various cancers. The researchers utilized the compound's structural flexibility to optimize binding affinity and selectivity, resulting in lead compounds with improved pharmacokinetic properties. This work underscores the potential of Methyl thiophene-2-carboxylate in addressing unmet medical needs in oncology.

In addition to its role in drug discovery, Methyl thiophene-2-carboxylate has been investigated for its applications in material science. A recent study in ACS Applied Materials & Interfaces reported its incorporation into conjugated polymers for organic electronics. The thiophene moiety's electron-rich nature enhances charge transport properties, making it a valuable component in the design of organic semiconductors and photovoltaic materials. These findings open new avenues for the development of sustainable and high-performance electronic devices.

Furthermore, the agrochemical industry has explored Methyl thiophene-2-carboxylate as a precursor for novel pesticides. A 2022 publication in Pest Management Science detailed its use in synthesizing thiophene-based fungicides with enhanced efficacy against resistant fungal strains. The study highlighted the compound's ability to disrupt fungal cell membranes, offering a promising strategy for combating crop diseases. This research aligns with the growing demand for environmentally friendly and effective agrochemicals.

Despite these advancements, challenges remain in the large-scale production and optimization of Methyl thiophene-2-carboxylate derivatives. Recent efforts have focused on green chemistry approaches to improve synthetic efficiency and reduce environmental impact. For instance, a 2023 study in Green Chemistry proposed a catalytic method for the esterification of thiophene-2-carboxylic acid, yielding Methyl thiophene-2-carboxylate with high purity and minimal waste. Such innovations are critical for the sustainable development of this compound and its derivatives.

In conclusion, Methyl thiophene-2-carboxylate (CAS: 5380-42-7) continues to be a focal point of research across multiple disciplines. Its versatility as a synthetic intermediate, combined with its bioactive and material properties, positions it as a valuable tool in chemical biology and pharmaceutical research. Future studies are expected to further elucidate its potential and address existing challenges, paving the way for innovative applications in medicine, electronics, and agriculture.

• 50340-79-9(5-(Methoxycarbonyl)thiophene-2-carboxylic acid)
• 5271-35-2(2-Thiophenecarboxylic acid, 2-thienylmethyl ester)
• 156910-49-5(5-(ethoxycarbonyl)-2-thiophenecarboxylic Acid)
• 61855-04-7(5-(Methoxymethyl)thiophene-2-carboxylic acid)
• 67808-64-4(Methyl 5-formylthiophene-2-carboxylate)
• 2810-04-0(Ethyl 2-thiophenecarboxylate)
• 4282-34-2(Dimethyl thiophene-2,5-dicarboxylate)
• 25569-97-5(Thiophene-2-carboxylic acid anhydride)
• 59303-19-4(2-Thiophenecarboxylic acid, propyl ester)
• 67808-65-5(Ethyl 5-formylthiophene-2-carboxylate)