Cas no 536-38-9 (2-bromo-1-(4-chlorophenyl)ethan-1-one)

2-Bromo-1-(4-chlorophenyl)ethan-1-one is a brominated aromatic ketone commonly used as a key intermediate in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals. Its reactive α-bromo ketone moiety makes it valuable for nucleophilic substitution reactions, enabling the introduction of functional groups or heterocyclic structures. The 4-chlorophenyl group enhances its stability and influences electronic properties, facilitating controlled reactivity in multi-step syntheses. This compound is characterized by high purity and consistent performance, making it suitable for research and industrial applications requiring precise molecular transformations. Proper handling is advised due to its potential lachrymatory and irritant properties.
2-bromo-1-(4-chlorophenyl)ethan-1-one structure
536-38-9 structure
Product Name:2-bromo-1-(4-chlorophenyl)ethan-1-one
CAS No:536-38-9
MF:C8H6BrClO
MW:233.489640712738
MDL:MFCD00000625
CID:38121
PubChem ID:87563586
Update Time:2025-06-13

2-bromo-1-(4-chlorophenyl)ethan-1-one Chemical and Physical Properties

Names and Identifiers

    • 2-Bromo-1-(4-chlorophenyl)ethanone
    • 4-Chlorophenacyl bromide
    • 2-Bromo-4-chloroacetophenone
    • omega-bromo-4-chloroacetophenone
    • bromomethyl p-chlorophenyl ketone
    • 4-Chloro Phencyl Bromide
    • 2,4-Dichloropentaphenone
    • A-BROMO-P-CHLOROACETOPHENONE
    • ALPHA-BROMO-P-CHLOROACETOPHENONE
    • AKOS 90589
    • 4-CHLORO-2'-BROMINE ACETOPHENONE
    • 4-Chloro-2'-bromoacetophenone
    • 2-BROMO-1-(4-CHLOROPHENYL)ETHAN-1-ONE
    • 2-bromo-4'-chloroacetophenone
    • 4-Chlorophenylacylbromide
    • 4'-Chloro-2-Bromoacetophenone
    • alpha-Bromo-4-chloro Acetophenone
    • α-Bromo-4-chloroacetophenone
    • 2-Bromo-4‘-chloroacetophenone
    • ω-Bromo-4-chloroacetophenone
    • p-Chlorophenacyl bromide
    • Ethanone, 2-bromo-1-(4-chlorophenyl)-
    • 4'-Chlorophenacyl bromide
    • 2-Bromo-p-chloroacetophenone
    • p-(Bromoacetyl)chlorobenzene
    • p-Chloro-omega-bromoacetophenone
    • omega-Bromo-p-chloroacetophenone
    • alpha-Bromo-4'-chloroacetophenone
    • Acetophenone, 2-bromo-4'-chloro-
    • NS00032800
    • 2-Bromo-1-(4-chlorophenyl)ethanone;2-Bromo-1-(4-chlorophenyl)ethanone
    • 4-Chloro-.alpha.-bromoacetophenone
    • p-Chloro-.omega.-bromoacetophenone
    • Halomethyl Phenyl Ketone deriv. 25
    • 2R0V40DI4R
    • 4-07-00-00651 (Beilstein Handbook Reference)
    • Q-102016
    • 4-Chloro-2-bromoacetophenone
    • A7804
    • B0568
    • AC-3116
    • NSC-8452
    • 2-bromo-1-(4-chlorophenyl)-ethanone
    • 536-38-9
    • .alpha.-Bromo-p-chloroacetophenone
    • Z104484576
    • 4-chloro-phenacyl bromide
    • 4-chlorophenacylbromide
    • SCHEMBL118608
    • EN300-20904
    • MFCD00000625
    • AKOS000210451
    • BDBM7877
    • 4-Chloro-alpha-bromoacetophenone
    • FT-0659442
    • 1-(4-Chlorophenyl)-2-bromo-1-ethanone
    • CHEMBL140061
    • InChI=1/C8H6BrClO/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2
    • FLAYZKKEOIAALB-UHFFFAOYSA-
    • 4-Chlorophenylacyl bromide
    • FT-0611440
    • AM20040657
    • NSC8452
    • 2-bromo-4'-chloroaceto-phenone
    • 2-Bromo-4'-chloroacetophenone (4-Chlorophenacyl bromide)
    • NSC 8452
    • PD136233
    • .omega.-Bromo-4-chloroacetophenone
    • CS-W014171
    • F0777-0569
    • I+/--Bromo-4-chloroacetophenone
    • Q27255497
    • alpha-Bromo-4-chloroacetophenone
    • .alpha.-Bromo-4'-chloroacetophenone
    • NCGC00186407-01
    • BROMOMETHYL 4-CHLOROPHENYL KETONE
    • 2-bromo-1-[4-chlorophenyl]ethanone
    • BP-13010
    • 4-Chloro-omega-bromoacetophenone
    • 2-bromo-4'-chloro-acetophenone
    • BRN 0607603
    • 2-Bromo-1-(4-chlorophenyl)ethanone #
    • .omega.-Bromo-p-chloroacetophenone
    • 2-Bromo-4'-chloroacetophenone, 98%
    • P-CHLOROPHENACYL BROMIDE [MI]
    • 2-Bromo-1-(4-chloro-phenyl)-ethanone
    • 2-Bromo-4`-chloroacetophenone
    • 2-Brom-1-(4-chlor-phenyl)-aethanon
    • 4-Chloro-.omega.-bromoacetophenone
    • 2-BROMO-1-(4-CHLOROPHENYL)-1-ETHANONE
    • BB 0221160
    • 1-Bromoacetyl-4-chlorobenzene
    • 2-BROMO-1-(4'-CHLOROPHENYL)ETHANONE
    • 2'-bromo-4-chloroacetophenone
    • DTXSID7060209
    • STR01162
    • 2-Bromo-4 inverted exclamation marka-chloroacetophenone
    • .alpha.-Bromo-4-chloroacetophenone
    • EINECS 208-631-5
    • UNII-2R0V40DI4R
    • 4-Chloro-2'-bromoacetophenone;p-Chlorophenacyl bromide; 2-Bromo-1-(4-chlorophenyl)ethanone
    • 208-631-5
    • DTXCID1041475
    • 2-bromo-1-(4-chlorophenyl)ethan-1-one
    • MDL： MFCD00000625
    • Inchi： 1S/C8H6BrClO/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2
    • InChI Key： FLAYZKKEOIAALB-UHFFFAOYSA-N
    • SMILES： BrCC(C1C=CC(=CC=1)Cl)=O
    • BRN： 607603

Computed Properties

  • Exact Mass: 231.92900
  • Monoisotopic Mass: 231.929
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 2
  • Complexity: 141
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 2
  • XLogP3: 3.1
  • Topological Polar Surface Area: 17.1

Experimental Properties

  • Color/Form: Acicular crystals
  • Density: 1.5624 (rough estimate)
  • Melting Point: 96.0 to 100.0 deg-C
  • Boiling Point: 186°C (rough estimate)
  • Flash Point: 129°C
  • Refractive Index: 1.5963 (estimate)
  • Water Partition Coefficient: Insoluble in water.
  • PSA: 17.07000
  • LogP: 2.91760
  • Solubility: Not determined
  • Merck: 2153
  • Sensitiveness: Lachrymatory

2-bromo-1-(4-chlorophenyl)ethan-1-one Security Information

  • Symbol: GHS05
  • Prompt：dangerous
  • Signal Word：Danger
  • Hazard Statement： H314
  • Warning Statement： P280-P305 + P351 + P338-P310
  • Hazardous Material transportation number：UN 3261 8/PG 2
  • WGK Germany：2
  • Hazard Category Code： 34
  • Safety Instruction： S26-S36/37/39-S45
  • FLUKA BRAND F CODES：19
  • RTECS：AM5978800
  • Hazardous Material Identification： C
  • Packing Group：III
  • Hazard Level：8
  • Packing Group：III
  • Risk Phrases：R22; R34
  • HazardClass：8
  • PackingGroup：III
  • TSCA：Yes
  • Toxicity：LD50 orally in mice: >2000 mg/kg (Dat-Xuong)
  • Storage Condition：Store at room temperature

2-bromo-1-(4-chlorophenyl)ethan-1-one Customs Data

  • HS CODE：2914399090
  • Customs Data：

    China Customs Code:

    2914399090

    Overview:

    2914399090. Other aromatic ketones without other oxygen-containing groups. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:5.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, Acetone declared packaging

    Summary:

    2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

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2-bromo-1-(4-chlorophenyl)ethan-1-one Suppliers

Suzhou Senfeida Chemical Co., Ltd
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(CAS:536-38-9)2-BROMO-4-CHLOROACETOPHENONE
Order Number:sfd9236
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:35
Price ($):discuss personally
Amadis Chemical Company Limited
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Audited Supplier Audited Supplier
(CAS:536-38-9)2-bromo-1-(4-chlorophenyl)ethan-1-one
Order Number:A1202897
Stock Status:in Stock
Quantity:500g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 02:49
Price ($):225.0

2-bromo-1-(4-chlorophenyl)ethan-1-one Related Literature

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Additional information on 2-bromo-1-(4-chlorophenyl)ethan-1-one

Comprehensive Overview of 2-Bromo-1-(4-chlorophenyl)ethan-1-one (CAS No. 536-38-9): Properties, Applications, and Industry Insights

2-Bromo-1-(4-chlorophenyl)ethan-1-one (CAS No. 536-38-9) is a specialized organic compound widely recognized in pharmaceutical and agrochemical research. Its molecular structure, featuring a bromo and 4-chlorophenyl moiety, makes it a versatile intermediate for synthesizing complex molecules. This article explores its physicochemical properties, industrial applications, and answers trending questions like "What is 2-bromo-1-(4-chlorophenyl)ethan-1-one used for?" and "How to synthesize 536-38-9?"—top queries in scientific databases.

The compound’s crystalline solid form and moderate solubility in organic solvents like ethanol and acetone facilitate its use in controlled reactions. Researchers prioritize its high purity grade (≥98%), as impurities can affect downstream processes. Recent studies highlight its role in developing non-toxic pesticides, aligning with the global shift toward eco-friendly agrochemicals—a hot topic in 2024. Analytical techniques such as HPLC and GC-MS are critical for quality verification, addressing the search term "How to analyze 2-bromo-1-(4-chlorophenyl)ethan-1-one."

In pharmaceuticals, 536-38-9 serves as a precursor for antimicrobial agents and kinase inhibitors, reflecting its relevance in drug discovery. A 2023 Journal of Medicinal Chemistry study noted its utility in modifying benzene rings to enhance bioactivity. This connects to frequent searches like "CAS 536-38-9 in drug development" and underscores its importance in structure-activity relationship (SAR) studies.

From an industrial perspective, manufacturers emphasize scalable synthesis routes for 2-bromo-1-(4-chlorophenyl)ethan-1-one, balancing cost and yield. A patented method involving bromination of 4-chloroacetophenone under mild conditions has gained traction, answering queries such as "Best synthesis method for 536-38-9." Safety protocols, including PPE and ventilation, are stressed in handling guidelines, though the compound is not classified under stringent hazard categories.

Environmental considerations are pivotal. The compound’s low bioaccumulation potential and rapid degradation in aerobic conditions make it preferable over persistent alternatives. Regulatory frameworks like REACH and EPA guidelines monitor its production, aligning with searches for "Is 2-bromo-1-(4-chlorophenyl)ethan-1-one environmentally safe?"

Emerging trends include its exploration in material science, particularly for organic semiconductors. A 2024 preprint revealed its derivatization into electron-transport layers for OLEDs, sparking interest in queries like "CAS 536-38-9 in electronics." Such interdisciplinary applications highlight its expanding utility beyond traditional sectors.

To conclude, 2-bromo-1-(4-chlorophenyl)ethan-1-one (CAS No. 536-38-9) remains a cornerstone in synthetic chemistry. Its adaptability across pharmaceuticals, agrochemicals, and advanced materials ensures sustained demand. For researchers, staying updated on green synthesis methods and analytical best practices is essential, as reflected in current academic and industrial discourse.

536-38-9 (2-bromo-1-(4-chlorophenyl)ethan-1-one) Related Products

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(CAS:536-38-9)2-BROMO-4-CHLOROACETOPHENONE
sfd9236
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Quantity:200kg
Price ($):Inquiry
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Amadis Chemical Company Limited
(CAS:536-38-9)2-bromo-1-(4-chlorophenyl)ethan-1-one
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Quantity:500g
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