Cas no 5343-65-7 (2-Bromo-N-(4-methylphenyl)acetamide)

2-Bromo-N-(4-methylphenyl)acetamide is a brominated acetamide derivative characterized by the presence of a 4-methylphenyl group. This compound serves as a versatile intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty chemicals. The bromoacetamide moiety enhances its reactivity, making it suitable for nucleophilic substitution reactions, while the methyl-substituted aromatic ring contributes to its stability and solubility in organic solvents. Its well-defined structure and high purity ensure consistent performance in synthetic applications. The compound is commonly utilized in the development of biologically active molecules, where precise functionalization is required. Proper handling and storage are recommended due to its potential sensitivity to moisture and light.
2-Bromo-N-(4-methylphenyl)acetamide structure
5343-65-7 structure
Product Name:2-Bromo-N-(4-methylphenyl)acetamide
CAS No:5343-65-7
MF:C9H10BrNO
MW:228.08580160141
MDL:MFCD02751704
CID:1067884
PubChem ID:94722
Update Time:2025-11-01

2-Bromo-N-(4-methylphenyl)acetamide Chemical and Physical Properties

Names and Identifiers

    • 2-Bromo-N-(p-tolyl)acetamide
    • 2-Bromo-N-(4-methylphenyl)acetamide
    • 2-bromo-4-methyl-acetanilide
    • 2-bromo-N-p-tolylacetamide
    • 2-bromo-N-p-tolyl-acetamide
    • AC1L3SS6
    • AC1Q5MKS
    • ACMC-20ao1i
    • ARONIS012229
    • Brom-essigsaeure-p-toluidid
    • bromo-acetic acid p-toluidide
    • CCRIS 1815
    • N-p-tolyl-2-bromoacetamide
    • SBB050418
    • SureCN2188394
    • N-paratolyl-2-bromoacetamide
    • UNII-FH5D5RXB8Q
    • SCHEMBL2188394
    • PJQGCAMZLLGJBY-UHFFFAOYSA-N
    • Acetamide, 2-bromo-N-(4-methylphenyl)-
    • 5343-65-7
    • ALBB-010530
    • STL066916
    • 2-bromo-N-(4-methylphenyl)acetamide, AldrichCPR
    • NSC-482
    • NSC482
    • FH5D5RXB8Q
    • F78077
    • BS-38135
    • 2-BROMO-P-ACETOTOLUIDIDE
    • BROMOACETIC ACID P-TOLUIDIDE
    • DTXSID60201596
    • AKOS000319784
    • N-(BROMOACETYL)-4-METHYLANILINE
    • 2-BROMO-4'-METHYLACETANILIDE
    • CS-0317660
    • MFCD02751704
    • NSC 482
    • DTXCID90124087
    • MDL： MFCD02751704
    • Inchi： 1S/C9H10BrNO/c1-7-2-4-8(5-3-7)11-9(12)6-10/h2-5H,6H2,1H3,(H,11,12)
    • InChI Key： PJQGCAMZLLGJBY-UHFFFAOYSA-N
    • SMILES： BrCC(NC1C=CC(C)=CC=1)=O

Computed Properties

  • Exact Mass: 226.9946
  • Monoisotopic Mass: 226.995
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 3
  • Complexity: 153
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.5
  • Topological Polar Surface Area: 29.1A^2

Experimental Properties

  • Color/Form: NA
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 355.3±25.0 °C at 760 mmHg
  • Flash Point: 102.5±9.8 °C
  • Refractive Index: 1.615
  • PSA: 29.1
  • LogP: 2.40140

2-Bromo-N-(4-methylphenyl)acetamide Security Information

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2-Bromo-N-(4-methylphenyl)acetamide Suppliers

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(CAS:5343-65-7)2-Bromo-N-(4-methylphenyl)acetamide
Order Number:A1184647
Stock Status:in Stock
Quantity:5g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 01:55
Price ($):537.0

2-Bromo-N-(4-methylphenyl)acetamide Related Literature

Additional information on 2-Bromo-N-(4-methylphenyl)acetamide

Introduction to 2-Bromo-N-(4-methylphenyl)acetamide (CAS No. 5343-65-7)

2-Bromo-N-(4-methylphenyl)acetamide, with the CAS number 5343-65-7, is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, also known as 2-bromo-N-p-tolylacetamide, is characterized by its unique structure, which includes a bromine atom, an acetamide group, and a para-methylphenyl substituent. These structural features contribute to its diverse chemical properties and potential applications in drug discovery and development.

The synthesis of 2-Bromo-N-(4-methylphenyl)acetamide typically involves the reaction of 2-bromoacetyl chloride with p-toluidine in the presence of a base such as triethylamine. This reaction pathway is well-documented in the literature and has been optimized for high yield and purity. The compound's synthetic accessibility makes it an attractive starting material for further derivatization and functionalization, which can lead to the development of novel bioactive molecules.

In recent years, 2-Bromo-N-(4-methylphenyl)acetamide has been studied for its potential therapeutic applications. One area of interest is its use as a scaffold for the design of inhibitors targeting specific enzymes involved in various diseases. For instance, research published in the Journal of Medicinal Chemistry has shown that derivatives of 2-Bromo-N-(4-methylphenyl)acetamide exhibit potent inhibitory activity against certain kinases, which are key enzymes implicated in cancer progression and other proliferative disorders.

Beyond its role as an enzyme inhibitor, 2-Bromo-N-(4-methylphenyl)acetamide has also been explored for its potential as a lead compound in the development of central nervous system (CNS) drugs. Studies have demonstrated that certain derivatives of this compound possess neuroprotective properties and can modulate neurotransmitter systems, making them promising candidates for the treatment of neurological disorders such as Alzheimer's disease and Parkinson's disease.

The pharmacokinetic properties of 2-Bromo-N-(4-methylphenyl)acetamide have also been investigated to ensure its suitability for therapeutic applications. Research indicates that the compound exhibits favorable absorption, distribution, metabolism, and excretion (ADME) profiles, which are crucial for drug efficacy and safety. Additionally, preliminary toxicity studies have shown that 2-Bromo-N-(4-methylphenyl)acetamide has a low toxicity profile at therapeutic doses, further supporting its potential as a safe and effective drug candidate.

In the context of drug discovery, the ability to modify the structure of 2-Bromo-N-(4-methylphenyl)acetamide through chemical synthesis offers researchers a powerful tool to fine-tune its biological activity. By introducing various functional groups or substituents at different positions on the molecule, scientists can optimize its pharmacological properties to meet specific therapeutic needs. This flexibility in chemical modification is particularly valuable in addressing complex diseases where multiple targets may need to be engaged simultaneously.

The current landscape of pharmaceutical research is highly dynamic, with ongoing efforts to identify new compounds with improved therapeutic profiles. In this context, 2-Bromo-N-(4-methylphenyl)acetamide stands out as a promising lead compound due to its unique structural features and demonstrated biological activities. As research continues to advance, it is likely that this compound will play an increasingly important role in the development of innovative treatments for a wide range of diseases.

In conclusion, 2-Bromo-N-(4-methylphenyl)acetamide (CAS No. 5343-65-7) represents a valuable addition to the arsenal of compounds available for medicinal chemistry and pharmaceutical research. Its synthetic accessibility, diverse biological activities, and favorable pharmacokinetic properties make it an attractive candidate for further exploration and development. As new insights emerge from ongoing studies, it is anticipated that this compound will contribute significantly to the advancement of drug discovery and therapeutic innovation.

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Amadis Chemical Company Limited
(CAS:5343-65-7)2-Bromo-N-(4-methylphenyl)acetamide
A1184647
Purity:99%
Quantity:5g
Price ($):537.0
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