• 1. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
• 2. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090
• 3. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 4. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Toluenes

Professional Introduction to 2-amino-1-(4-methylphenyl)ethan-1-ol (CAS No. 53360-85-3)

2-amino-1-(4-methylphenyl)ethan-1-ol, identified by its Chemical Abstracts Service (CAS) number 53360-85-3, is a significant compound in the realm of pharmaceutical chemistry and bioorganic synthesis. This molecule, featuring a primary amine group and an aromatic benzyl moiety, has garnered attention due to its structural versatility and potential applications in medicinal chemistry. The presence of a methyl substituent at the para position of the phenyl ring enhances its reactivity, making it a valuable intermediate in the synthesis of more complex pharmacophores.

The compound’s structural framework, characterized by a chiral center at the ethyl group attached to the benzyl ring, opens avenues for exploring stereoselective synthesis and drug design. In recent years, advancements in computational chemistry have enabled researchers to predict the pharmacokinetic properties of such molecules with greater precision. Studies suggest that 2-amino-1-(4-methylphenyl)ethan-1-ol exhibits favorable solubility parameters, which could be leveraged in formulating novel drug delivery systems.

One of the most compelling aspects of this compound is its role as a precursor in the development of bioactive molecules. Researchers have utilized derivatives of 2-amino-1-(4-methylphenyl)ethan-1-ol to design inhibitors targeting enzyme-mediated pathways implicated in neurological disorders. For instance, modifications to its aromatic core have led to the discovery of compounds with potential neuroprotective properties. These findings align with the growing interest in small-molecule modulators that can interact with central nervous system receptors without significant off-target effects.

The synthesis of 2-amino-1-(4-methylphenyl)ethan-1-ol typically involves multi-step organic transformations, including nucleophilic substitution and reduction reactions. The para-substituted methylbenzene derivative serves as a key starting material, which undergoes functionalization to introduce the amino and ethyl groups. Recent innovations in catalytic methods have streamlined these processes, reducing reaction times and improving yields. Such improvements are critical for scaling up production while maintaining cost-effectiveness, which is essential for industrial applications.

In the context of drug discovery, 2-amino-1-(4-methylphenyl)ethan-1-ol has been incorporated into libraries designed for high-throughput screening (HTS). Its structural features make it amenable to virtual screening protocols, where computational models predict interactions with biological targets. This approach has accelerated the identification of lead compounds for further optimization. Moreover, its stability under various storage conditions enhances its utility as an archival sample in medicinal chemistry collections.

The compound’s potential extends beyond pharmaceutical applications; it has shown promise in materials science as a building block for functional polymers. The incorporation of 2-amino-1-(4-methylphenyl)ethan-1-ol into polymer backbones can impart specific physicochemical properties, such as enhanced thermal stability or biodegradability. These attributes are particularly relevant in developing sustainable materials for medical implants or biodegradable coatings.

Regulatory considerations play a crucial role in the handling and commercialization of 2-amino-1-(4-methylphenyl)ethan-1-ol. While it does not fall under hazardous or controlled substance classifications, adherence to good manufacturing practices (GMP) ensures consistency and safety across batches. Documentation of synthetic routes and purity assessments are mandatory for compliance with international standards set by agencies like the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA).

The future research trajectory for this compound is multifaceted. Investigations into its metabolic pathways could provide insights into how it behaves within biological systems, informing drug design strategies. Additionally, exploring its derivatives may uncover novel therapeutic agents targeting diseases with unmet medical needs. Collaborative efforts between academia and industry are essential to translate these findings into tangible benefits for patients worldwide.

In summary, 2-amino-1-(4-methylphenyl)ethan-1-ol (CAS No. 53360-85-3) represents a versatile chemical entity with broad applications in pharmaceuticals and materials science. Its unique structural attributes and reactivity profile position it as a cornerstone molecule for innovation-driven research. As scientific methodologies continue to evolve, so too will our understanding and utilization of this compound, reinforcing its significance in modern chemistry.

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