• 1. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
• 2. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives

3'-Nitro-[1,1'-biphenyl]-4-ol (CAS No. 53059-30-6): An Overview of Its Properties, Applications, and Recent Research

3'-Nitro-[1,1'-biphenyl]-4-ol (CAS No. 53059-30-6) is a versatile compound with a wide range of applications in the fields of chemistry, biology, and pharmaceuticals. This compound is characterized by its unique molecular structure, which includes a biphenyl core and a nitro group at the 3' position, along with a hydroxyl group at the 4 position. These structural features contribute to its distinct chemical and biological properties, making it a subject of interest in various scientific studies.

The molecular formula of 3'-Nitro-[1,1'-biphenyl]-4-ol is C₁₂H₉NO₃, and its molecular weight is approximately 219.20 g/mol. The compound is known for its solubility in organic solvents such as ethanol and dimethyl sulfoxide (DMSO), but it has limited solubility in water. This solubility profile makes it suitable for use in various chemical reactions and biological assays.

In terms of physical properties, 3'-Nitro-[1,1'-biphenyl]-4-ol appears as a white to off-white crystalline solid at room temperature. It has a melting point ranging from 178 to 180°C, which is an important parameter for its handling and storage. The compound is stable under normal laboratory conditions but should be protected from moisture and light to maintain its integrity.

The chemical reactivity of 3'-Nitro-[1,1'-biphenyl]-4-ol is influenced by its functional groups. The nitro group can undergo reduction to form an amino group, which can be further modified through various synthetic routes. The hydroxyl group can participate in nucleophilic substitution reactions and can be esterified or etherified to produce derivatives with different properties. These reactivity features make 3'-Nitro-[1,1'-biphenyl]-4-ol a valuable intermediate in organic synthesis.

In the field of medicinal chemistry, 3'-Nitro-[1,1'-biphenyl]-4-ol has been studied for its potential therapeutic applications. Recent research has focused on its anti-inflammatory and anti-cancer properties. For instance, studies have shown that derivatives of 3'-Nitro-[1,1'-biphenyl]-4-ol can inhibit the activity of cyclooxygenase (COX) enzymes, which are key targets in the treatment of inflammatory diseases such as arthritis. Additionally, some derivatives have demonstrated cytotoxic effects against various cancer cell lines, suggesting their potential as lead compounds for drug development.

The biological activity of 3'-Nitro-[1,1'-biphenyl]-4-ol is also influenced by its ability to interact with biological targets. Research has indicated that the compound can modulate the activity of certain enzymes and receptors involved in cellular signaling pathways. For example, it has been shown to inhibit the activity of protein kinases, which are important regulators of cell growth and proliferation. This property makes it a promising candidate for the development of targeted therapies for diseases characterized by aberrant kinase activity.

In addition to its therapeutic potential, 3'-Nitro-[1,1'-biphenyl]-4-ol has been explored for its use in materials science and nanotechnology. Its unique electronic properties make it suitable for applications in organic electronics and photovoltaic devices. For instance, derivatives of the compound have been used to fabricate organic light-emitting diodes (OLEDs) and solar cells with improved performance characteristics.

The environmental impact of 3'-Nitro-[1,1'-biphenyl]-4-ol is another area of interest. Studies have investigated its biodegradability and potential toxicity to aquatic organisms. While the compound itself is not considered highly toxic, its breakdown products may have different environmental profiles. Therefore, ongoing research is focused on understanding the fate and effects of 3'-Nitro-[1,1'-biphenyl]-4-ol in the environment to ensure its safe use in industrial applications.

In conclusion, 3'-Nitro-[1,1'-biphenyl]-4-ol (CAS No. 53059-30-6) is a multifaceted compound with diverse applications in chemistry, biology, pharmaceuticals, materials science, and environmental science. Its unique molecular structure confers it with valuable chemical and biological properties that make it an important subject of ongoing research. As new derivatives and applications continue to be discovered, the significance of this compound in various scientific fields is likely to grow.

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