• 1. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
• 2. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020
• 3. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 4. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Organic sulfonic acids and derivatives Organosulfonic acids and derivatives

Comprehensive Overview of 5-Bromo-N-methanesulfonylpentanamide (CAS No. 52533-64-9): Properties, Applications, and Industry Insights

5-Bromo-N-methanesulfonylpentanamide (CAS 52533-64-9) is a specialized organic compound gaining attention in pharmaceutical and agrochemical research due to its unique sulfonamide-based structure. As a brominated sulfonamide derivative, it serves as a versatile intermediate in synthetic chemistry, particularly in the development of bioactive molecules. The compound's molecular formula C₆H₁₂BrNO₃S features both sulfonyl and amide functional groups, enabling diverse reactivity patterns that align with current trends in green chemistry and atom-efficient synthesis.

Recent literature highlights the growing demand for sulfonamide-based building blocks like 52533-64-9 in drug discovery programs. Pharmaceutical researchers particularly value its potential for creating metalloenzyme inhibitors, a hot topic in antibiotic development amid rising antimicrobial resistance concerns. The bromine atom at the 5-position allows for further functionalization via cross-coupling reactions – a technique frequently searched in connection with palladium-catalyzed transformations and C-C bond formation strategies.

From a physicochemical perspective, 5-bromo-N-methanesulfonylpentanamide typically appears as a white to off-white crystalline powder with moderate solubility in polar organic solvents. Its stability profile makes it suitable for high-throughput screening applications, answering industry needs for stable synthetic intermediates that can withstand various reaction conditions. Analytical data shows characteristic peaks in FTIR spectra at 1700-1650 cm^-1 (amide C=O stretch) and 1350-1300 cm^-1 (sulfonyl S=O stretch), important markers for quality control in contract manufacturing organizations (CMOs).

The compound's applications extend to material science, where researchers explore its potential as a monomer precursor for specialty polymers. This aligns with the booming interest in functional materials for electronics and coatings. Patent analysis reveals increasing references to CAS 52533-64-9 in filings related to photoactive compounds and charge-transfer complexes, particularly in Asian markets where electronic chemicals represent a growing sector.

Quality specifications for 5-bromo-N-methanesulfonylpentanamide typically require ≥98% purity by HPLC, with particular attention to residual solvent levels. This reflects the pharmaceutical industry's focus on ICH guidelines and impurity profiling – frequently searched terms in regulatory chemistry circles. Storage recommendations generally suggest protection from moisture at 2-8°C, addressing stability concerns common to sulfonamide compounds.

Emerging research directions include the compound's potential in proteolysis-targeting chimeras (PROTACs), a cutting-edge area in drug discovery. The sulfonyl moiety's ability to engage with E3 ubiquitin ligases makes 52533-64-9 an interesting candidate for targeted protein degradation studies – a trending topic in bioconjugation chemistry forums and publications.

From a commercial standpoint, suppliers increasingly highlight 5-bromo-N-methanesulfonylpentanamide in catalogs of pharmaceutical intermediates, with current market analysis showing steady demand from North American and European research centers. The compound's scalable synthesis route – often starting from affordable bromovaleric acid derivatives – makes it economically viable for kilolab production, addressing frequent queries about cost-effective scaling in process chemistry.

Environmental and handling considerations emphasize standard laboratory precautions, with particular attention to the compound's biodegradability profile – a key concern in modern green chemistry initiatives. Recent lifecycle assessments of similar sulfonamides suggest moderate environmental persistence, prompting research into improved waste treatment methods for brominated byproducts.

Analytical method development for 5-bromo-N-methanesulfonylpentanamide frequently employs UHPLC-MS techniques, reflecting the pharmaceutical industry's shift toward high-resolution mass spectrometry. Method optimization studies often focus on achieving baseline separation from potential process-related impurities – another highly searched term in quality control contexts.

Future outlooks suggest expanding applications in peptide mimetics design, where the compound's structural features could enable novel bioisosteric replacements. This potential aligns with growing interest in conformational restriction strategies for improving drug candidate properties, making CAS 52533-64-9 a compound to watch in medicinal chemistry innovation.

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