Cas no 52516-43-5 ((2-Chloro-3-methoxyphenyl)methanol)

(2-Chloro-3-methoxyphenyl)methanol is a versatile aromatic alcohol featuring both chloro and methoxy substituents on the phenyl ring. Its bifunctional structure makes it valuable as an intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty chemicals. The presence of the hydroxymethyl group allows for further derivatization, such as oxidation to aldehydes or carboxylic acids, while the chloro and methoxy groups offer sites for selective functionalization. This compound exhibits moderate stability under standard conditions, facilitating handling and storage. Its well-defined reactivity profile enables precise control in multi-step synthetic routes, making it a useful building block for complex molecular architectures.
(2-Chloro-3-methoxyphenyl)methanol structure
52516-43-5 structure
Product Name:(2-Chloro-3-methoxyphenyl)methanol
CAS No:52516-43-5
MF:C8H9ClO2
MW:172.608861684799
MDL:MFCD18393574
CID:1092932
PubChem ID:21580656
Update Time:2025-10-05

(2-Chloro-3-methoxyphenyl)methanol Chemical and Physical Properties

Names and Identifiers

    • (2-Chloro-3-methoxyphenyl)methanol
    • 2-chloro-3-methoxybenzyl alcohol
    • SB84992
    • CCA51643
    • N12987
    • 52516-43-5
    • MFCD18393574
    • EN300-198614
    • DA-26657
    • CS-0193914
    • SCHEMBL7672640
    • Benzenemethanol, 2-chloro-3-methoxy-
    • MDL: MFCD18393574
    • Inchi: 1S/C8H9ClO2/c1-11-7-4-2-3-6(5-10)8(7)9/h2-4,10H,5H2,1H3
    • InChI Key: JYHHZWHNWLNIMT-UHFFFAOYSA-N
    • SMILES: ClC1C(=CC=CC=1CO)OC

Computed Properties

  • Exact Mass: 172.02900
  • Monoisotopic Mass: 172.0291072g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 2
  • Complexity: 119
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 1.6
  • Topological Polar Surface Area: 29.5?2

Experimental Properties

  • PSA: 29.46000
  • LogP: 1.84090

(2-Chloro-3-methoxyphenyl)methanol Customs Data

  • HS CODE:2909499000
  • Customs Data:

    China Customs Code:

    2909499000

    Overview:

    2909499000 Other ether alcohols and their halogenation\sulfonation\Nitrosative or nitrosative derivatives. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:5.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

(2-Chloro-3-methoxyphenyl)methanol Pricemore >>

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(2-Chloro-3-methoxyphenyl)methanol Related Literature

Additional information on (2-Chloro-3-methoxyphenyl)methanol

Introduction to (2-Chloro-3-methoxyphenyl)methanol (CAS No 52516-43-5)

(2-Chloro-3-methoxyphenyl)methanol, also known by its CAS registry number CAS No 52516-43-5, is a versatile organic compound with significant applications in various fields of chemistry and pharmacology. This compound is characterized by its unique structure, which includes a phenolic ring substituted with a chlorine atom at the 2-position and a methoxy group at the 3-position, along with a hydroxymethyl group attached to the aromatic ring. The combination of these functional groups imparts distinctive chemical and physical properties to the molecule, making it an interesting subject of study for researchers and industry professionals alike.

The synthesis of (2-Chloro-3-methoxyphenyl)methanol typically involves multi-step organic reactions, often starting from readily available aromatic precursors. Recent advancements in synthetic methodologies have enabled more efficient and selective routes for the preparation of this compound, minimizing by-products and enhancing overall yield. These improvements are particularly valuable in large-scale production settings, where cost-effectiveness and sustainability are critical considerations.

One of the most notable applications of CAS No 52516-43-5 lies in its use as an intermediate in pharmaceutical chemistry. The compound serves as a key building block for the synthesis of various bioactive molecules, including potential drug candidates targeting specific therapeutic areas such as cancer, inflammation, and neurodegenerative diseases. Its ability to undergo a wide range of functional group transformations makes it highly adaptable to diverse synthetic strategies.

In addition to its role in drug discovery, (2-Chloro-3-methoxyphenyl)methanol has found applications in material science, particularly in the development of advanced polymers and coatings. The hydroxymethyl group present in the molecule can participate in polymerization reactions, leading to materials with tailored mechanical and thermal properties. Recent studies have explored its potential as a monomer for synthesizing biodegradable polymers, which hold promise for use in sustainable packaging and biomedical devices.

The chemical stability of CAS No 52516-43-5 under various environmental conditions has been extensively studied. Research indicates that the compound exhibits good stability under normal storage conditions but may undergo degradation under extreme pH or temperature conditions. Understanding these stability parameters is crucial for ensuring the reliability and shelf-life of products incorporating this compound.

From an analytical standpoint, modern spectroscopic techniques such as NMR (Nuclear Magnetic Resonance) and MS (Mass Spectrometry) have been instrumental in confirming the structure and purity of (2-Chloro-3-methoxyphenyl)methanol. These techniques provide detailed insights into the molecular architecture, enabling precise characterization and quality control during manufacturing processes.

In terms of environmental impact, recent studies have focused on assessing the biodegradability and eco-toxicity of CAS No 52516-43-5. Findings suggest that under controlled conditions, the compound can undergo microbial degradation, reducing its persistence in natural ecosystems. However, further research is needed to fully understand its long-term environmental effects and develop strategies for safe disposal.

The versatility of (2-Chloro-3-methoxyphenyl)methanol continues to drive innovation across multiple disciplines. Its unique combination of functional groups offers endless possibilities for chemical modification, making it a valuable asset in both academic research and industrial applications. As advancements in synthetic chemistry and materials science continue to evolve, this compound is poised to play an increasingly important role in shaping future technologies.

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