• 1. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 2. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig
• 3. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 4. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 5. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl cyanides
• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

2-(3,5-Dichlorophenyl)Acetonitrile: A Comprehensive Overview

CAS No 52516-37-7, commonly referred to as 2-(3,5-Dichlorophenyl)Acetonitrile, is a chemical compound that has garnered significant attention in various scientific and industrial domains. This compound is characterized by its unique structure, which includes a dichlorophenyl group attached to an acetonitrile moiety. The presence of the dichlorophenyl group imparts distinctive chemical properties, making it a valuable component in numerous applications.

The structural formula of 2-(3,5-Dichlorophenyl)Acetonitrile reveals a benzene ring substituted with two chlorine atoms at the 3 and 5 positions. This substitution pattern not only enhances the stability of the molecule but also contributes to its reactivity in various chemical reactions. The acetonitrile group further adds functionality, enabling this compound to participate in nucleophilic substitutions and other transformations that are critical in organic synthesis.

Recent studies have highlighted the potential of CAS No 52516-37-7 in the field of pharmacology. Researchers have explored its role as a precursor in the synthesis of bioactive compounds, particularly those with antifungal and antibacterial properties. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated that derivatives of this compound exhibit potent activity against several pathogenic fungi, suggesting its potential as a lead compound in drug development.

In addition to its pharmacological applications, 2-(3,5-Dichlorophenyl)Acetonitrile has found utility in agrochemicals. Its ability to act as an intermediate in the synthesis of pesticides has been well-documented. A recent investigation by agricultural scientists revealed that compounds derived from this structure can effectively target specific enzymes in pests, leading to their inhibition without causing harm to non-target organisms. This dual functionality underscores its importance in both therapeutic and agricultural sectors.

The synthesis of CAS No 52516-37-7 typically involves multi-step processes that require precise control over reaction conditions. One common approach involves the Friedel-Crafts acylation of chlorobenzene derivatives followed by subsequent modifications to introduce the acetonitrile group. The optimization of these steps has been a focus of recent research efforts, with chemists exploring greener methodologies that reduce environmental impact while maintaining high yields.

From an environmental perspective, understanding the fate and transport of 2-(3,5-Dichlorophenyl)Acetonitrile is crucial for assessing its potential risks. Studies conducted under controlled laboratory conditions have shown that this compound exhibits moderate biodegradability under aerobic conditions. However, further research is needed to evaluate its behavior in natural ecosystems and its potential for bioaccumulation.

In conclusion, CAS No 52516-37-7, or 2-(3,5-Dichlorophenyl)Acetonitrile, stands as a versatile compound with diverse applications across multiple disciplines. Its unique chemical structure and reactivity make it an invaluable tool in organic synthesis, while its bioactive properties position it as a promising candidate for future drug development. As research continues to uncover new insights into its properties and applications, this compound is likely to play an increasingly significant role in both academic and industrial settings.

• 140-53-4(2-(4-chlorophenyl)acetonitrile)
• 191106-24-8(2-(4-Chloronaphthalen-2-yl)acetonitrile)
• 55405-39-5(1,4-Benzenediacetonitrile, 2,3,5,6-tetrachloro-)
• 3218-50-6(2-(2,5-dichlorophenyl)acetonitrile)
• 3215-64-3(2,6-Dichlorophenylacetonitrile)
• 3218-49-3(3,4-Dichlorophenylacetonitrile)
• 6306-60-1(2,4-Dichlorophenylacetonitrile)
• 1529-41-5(3-Chlorobenzyl cyanide)
• 99726-59-7(Propanedinitrile,(3-chlorophenyl)- (9CI))
• 3215-65-4(Benzeneacetonitrile,2,3,6-trichloro-)