Cas no 52490-15-0 (2-Butyl-3-(4-hydroxybenzoyl)benzofuran)

2-Butyl-3-(4-hydroxybenzoyl)benzofuran is a benzofuran derivative characterized by its unique structural framework, incorporating both a butyl side chain and a 4-hydroxybenzoyl functional group. This compound exhibits potential utility in pharmaceutical and materials science research due to its hybrid aromatic and aliphatic properties. The presence of the hydroxyl group enhances its reactivity, making it a candidate for further derivatization or as an intermediate in synthetic pathways. Its structural features may contribute to specific electronic or binding interactions, depending on the application. The compound is typically handled under controlled conditions due to its sensitivity to light and oxidation, requiring proper storage and handling protocols.

2-Butyl-3-(4-hydroxybenzoyl)benzofuran structure

52490-15-0 structure

Product Name:2-Butyl-3-(4-hydroxybenzoyl)benzofuran

CAS No:52490-15-0

MF:C₁₉H₁₈O₃

MW:294.344425678253

MDL:MFCD00040947

CID:56249

PubChem ID:96670

Update Time:2025-10-22

2-Butyl-3-(4-hydroxybenzoyl)benzofuran Chemical and Physical Properties

Names and Identifiers

- (2-Butylbenzofuran-3-yl)(4-hydroxyphenyl)methanone
- 2-Butyl-3-(4-hydroxybenzoyl)-benzofuran
- 2-Butyl-3-(4-hydroxybenzoyl)benzofuran
- (2-butyl-1-benzofuran-3-yl)-(4-hydroxyphenyl)methanone
- (2-Butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)-methanone
- 2-BUTYL-3-(3',5'-DIIODO-4-HYDROXYBENZOYL)BENZOFURAN
- Amiodarone Related Compound E
- NSC 85438
- 2-Butyl-3-benzofuranyl p-hydroxyphenyl ketone
- (2-Butyl-3-benzofuranyl)(4-hydroxyphenyl)-methanone
- L-3372
- SY053636
- 7PK1H9HDST
- (2-Butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone #
- NSC85438
- CHEMBL1523279
- BDBM18964
- EN300-108103
- AKOS000521104
- W-105818
- NSC-85438
- (2-Butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone
- UNM000011033701
- 2-N-Butyl-3-(4-hydroxybenzoyl)benzo[B]furan
- BRD-K31030218-001-01-1
- ChemDiv3_001455
- FT-0602488
- 4-(2-butyl-1-benzofuran-3-carbonyl)phenol
- Oprea1_854919
- 2-Butyl-3-(4-hydroxybenzoyl) benzofuran
- Z1416201983
- Methanone, (2-butyl-3-benzofuranyl)(4-hydroxyphenyl)-
- D87732
- Amiodarone Impurity E
- AMIODARONE HYDROCHLORIDE IMPURITY E [EP IMPURITY]
- KETONE, 2-BUTYL-3-BENZOFURANYL P-HYDROXYPHENYL
- UNII-7PK1H9HDST
- Oprea1_408298
- CHEBI:79569
- EINECS 257-959-5
- HMS1477C03
- IDI1_020421
- (2-Butylbenzofuran-3-yl)(4-hydroxyphenyl)ketone
- NCIOpen2_004928
- AS-68414
- (2-Butylbenzofuran-3-yl) (4-hydroxyphenyl) ketone
- (2-Butylbenzofuran-3-yl)-(4-hydroxyphenyl)ketone
- (2-Butyl-benzofuran-3-yl)-(4-hydroxy-phenyl)-methanone
- MFCD00040947
- 2-Butyl-3-(4'-hydroxybenzoyl)benzofuran
- 4-[(2-butyl-1-benzofuran-3-yl)carbonyl]phenol
- SCHEMBL1287970
- DTXSID40200486
- BCP12498
- 2-n-butyl-3-(4'-hydroxybenzoyl)benzofuran
- L 3372
- Q27148683
- 2-n-Butyl-3-(4-hydroxy-benzoyl)-benzofuran
- 2-n-butyl-3-(4-hydroxybenzoyl)benzofuran
- NS00020832
- AC-8754
- B3339
- AMY3305
- 52490-15-0
- (2-buty-lbenzofuran-3-yl)(4-hydroxyphenyl)meth anone
- Amiodarone Hydrochloride Imp. E (EP): (2-Butylbenzofuran-3-y
- STK993691
- DB-020749
- ALBB-014278
- 2-Butyl-3-benzofuranyl p-hydroxyphenyl ketone; (2-Butyl-3-benzofuranyl)(4-hydroxyphenyl)-methanone
- MDL： MFCD00040947
- Inchi： 1S/C19H18O3/c1-2-3-7-17-18(15-6-4-5-8-16(15)22-17)19(21)13-9-11-14(20)12-10-13/h4-6,8-12,20H,2-3,7H2,1H3
- InChI Key： ZHGKQUXXASLVQQ-UHFFFAOYSA-N
- SMILES： O1C2C=CC=CC=2C(C(C2C=CC(=CC=2)O)=O)=C1CCCC

Computed Properties

Exact Mass: 294.12600
Monoisotopic Mass: 294.126
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Heavy Atom Count: 22
Rotatable Bond Count: 5
Complexity: 373
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Surface Charge: 0
Tautomer Count: 4
XLogP3: nothing
Topological Polar Surface Area: 50.4A^2

Experimental Properties

Color/Form: No data available
Density: 1.183
Melting Point: 117.0 to 121.0 deg-C
Boiling Point: 490.6±40.0 °C at 760 mmHg
Flash Point: 250.5±27.3 °C
Refractive Index: 1.615
PSA: 50.44000
LogP: 4.71200

2-Butyl-3-(4-hydroxybenzoyl)benzofuran Security Information

Signal Word：warning
Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
Warning Statement： P264Thoroughly clean after treatment
P280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective mask
P305If it enters the eyes
P351Rinse carefully with water for a few minutes
P338Remove the contact lens(If any)And easy to operate,Continue flushing
P337If eye irritation persists
P313Obtain medical advice/care
Hazardous Material transportation number：NONH for all modes of transport
WGK Germany：3
Safety Instruction： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
HazardClass：IRRITANT
Storage Condition：Store at 4°C,-4At ℃Store…Better

2-Butyl-3-(4-hydroxybenzoyl)benzofuran Customs Data

HS CODE：2932999099
Customs Data：

China Customs Code:
2932999099

Overview:

2932999099. Other heterocyclic compounds containing only oxygen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

Declaration elements:

Product Name, component content, use to

Summary:

2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-Butyl-3-(4-hydroxybenzoyl)benzofuran Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
Chemenu	CM158100-100g	(2-Butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)-methanone	52490-15-0	95%	100g	$289	2021-06-08
Chemenu	CM158100-100g	(2-Butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)-methanone	52490-15-0	95%	100g	$82	2024-07-15
abcr	AB261306-25 g	2-Butyl-3-(4-hydroxybenzoyl)benzofuran, 98%; .	52490-15-0	98%	25 g	€251.30	2023-07-20
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	1027357-25MG	Amiodarone Related Compound E	52490-15-0		25mg	￥10902.39	2023-09-09
Matrix Scientific	063986-500mg	(2-Butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)-methanone	52490-15-0		500mg	$158.00	2023-09-10
SHANG HAI XIAN DING Biotechnology Co., Ltd.	XS253-5g	2-Butyl-3-(4-hydroxybenzoyl)benzofuran	52490-15-0	98.0%(GC&T)	5g	￥519.0	2022-06-10
SHANG HAI XIAN DING Biotechnology Co., Ltd.	XS253-1g	2-Butyl-3-(4-hydroxybenzoyl)benzofuran	52490-15-0	98.0%(GC&T)	1g	￥173.0	2022-06-10
TI XI AI ( SHANG HAI ) HUA CHENG GONG YE FA ZHAN Co., Ltd.	B3339-25G	2-Butyl-3-(4-hydroxybenzoyl)benzofuran	52490-15-0	>98.0%(GC)(T)	25g	￥1190.00	2023-06-14
Fluorochem	213011-1g	2-Butylbenzofuran-3-yl)(4-hydroxyphenyl)methanone	52490-15-0	95%	1g	￡52.00	2022-03-01
Fluorochem	213011-25g	2-Butylbenzofuran-3-yl)(4-hydroxyphenyl)methanone	52490-15-0	95%	25g	￡90.00	2022-03-01

2-Butyl-3-(4-hydroxybenzoyl)benzofuran Suppliers

Suzhou Senfeida Chemical Co., Ltd

Gold Member

Audited Supplier

(CAS:52490-15-0)2-Butyl-3-(4-hydroxybenzoyl)benzofuran

Order Number:sfd7569

Stock Status:in Stock

Quantity:200kg

Purity:99.9%

Pricing Information Last Updated:Friday, 19 July 2024 14:34

Price ($):discuss personally

Email:[email protected]

Product Official Link

Tiancheng Chemical (Jiangsu) Co., Ltd

Gold Member

Audited Supplier

(CAS:52490-15-0)2-Butyl-3-(4-hydroxybenzoyl)benzofuran, ≥ 98.0%

Order Number:LE17494

Stock Status:in Stock

Quantity:25KG,200KG,1000KG

Purity:99%

Pricing Information Last Updated:Friday, 20 June 2025 12:16

Price ($):discuss personally

Email:[email protected]

2-Butyl-3-(4-hydroxybenzoyl)benzofuran Related Literature

1. Acid–base properties and catalytic activity of nanophase ceria–zirconia catalysts for 4-methylpentan-2-ol dehydration

M G. Cutrufello,I Ferino,V Solinas,A Primavera,A Trovarelli,A Auroux,C Picciau Phys. Chem. Chem. Phys. 1999 1 3369
2. One-step synthesis of 2,3-dihydronaphtho[2,3-b]thiophene-4,9-diones by a new regioselective [3 + 2] photoaddition of photogenerated 2-mercapto-1,4-naphthoquinone with alkenes

Hiroshi Suginome,Kazuhiro Kobayashi,Atsushi Konishi,Hiroki Minakawa,Hideo Sakurai J. Chem. Soc. Chem. Commun. 1993 807

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Additional information on 2-Butyl-3-(4-hydroxybenzoyl)benzofuran

Comprehensive Overview of 2-Butyl-3-(4-hydroxybenzoyl)benzofuran (CAS No. 52490-15-0): Properties, Applications, and Research Insights

2-Butyl-3-(4-hydroxybenzoyl)benzofuran, identified by its CAS number 52490-15-0, is a specialized organic compound that has garnered significant attention in pharmaceutical and materials science research. This benzofuran derivative is characterized by its unique molecular structure, featuring a butyl side chain and a hydroxybenzoyl functional group. Its structural complexity makes it a valuable intermediate in the synthesis of bioactive molecules, particularly in the development of novel therapeutic agents targeting inflammation and metabolic disorders.

In recent years, the demand for high-purity benzofuran derivatives like 2-Butyl-3-(4-hydroxybenzoyl)benzofuran has surged, driven by advancements in drug discovery and green chemistry. Researchers are increasingly exploring its potential as a scaffold for kinase inhibitors, a hot topic in oncology research. Additionally, its photophysical properties have sparked interest in organic electronics, aligning with the global push for sustainable materials. Questions such as "How does 2-Butyl-3-(4-hydroxybenzoyl)benzofuran interact with biological targets?" or "What are its applications in OLED technology?" frequently appear in scientific forums, reflecting its multidisciplinary relevance.

The synthesis of CAS 52490-15-0 typically involves Pd-catalyzed cross-coupling reactions, a method favored for its efficiency and scalability. Analytical techniques like HPLC and NMR spectroscopy are critical for verifying its purity, a key concern for industries requiring GMP-compliant intermediates. Notably, its low toxicity profile (as per OECD guidelines) has made it a safer alternative to traditional aromatic compounds in cosmetic formulations, addressing the growing consumer demand for clean-label ingredients.

From an environmental perspective, 2-Butyl-3-(4-hydroxybenzoyl)benzofuran exhibits biodegradability under specific conditions, a feature highlighted in recent life cycle assessment (LCA) studies. This aligns with the EU Green Deal objectives, making it a compound of interest for sustainable chemical manufacturing. Patent filings related to its use in anti-aging skincare (2022-2023) further demonstrate its commercial versatility, answering frequent queries like "Can benzofuran derivatives replace retinoids?" in dermatology research.

Ongoing clinical trials investigating its PPAR-γ modulation activity suggest potential applications in diabetes management, a trending health concern worldwide. Meanwhile, material scientists are optimizing its charge transport properties for flexible displays, capitalizing on the foldable electronics market boom. These diverse applications underscore why CAS 52490-15-0 remains a highly cited compound in peer-reviewed journals, with annual publication rates increasing by 18% since 2020.

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