• 1. An aqueous ammonia sensor based on an inkjet-printed polyaniline nanoparticle-modified electrode
  Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399
• 2. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 3. Aluminium alkyl and aryloxide complexes of pyrazine and bipyridines: synthesis and structure?
  Doug Ogrin,Laura H. van Poppel,Simon G. Bott,Andrew R. Barron Dalton Trans., 2004, 3689-3694
• 4. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 5. An integrated microfluidic platform for sensitive and rapid detection of biological toxins?
  Robert J. Meagher,Anson V. Hatch,Ronald F. Renzi,Anup K. Singh Lab Chip, 2008,8, 2046-2053

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alkyl aryl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Alkyl aryl ethers
• Solvents and Organic Chemicals Organic Compounds

Recent Advances in the Study of 2-Chloro-4-ethoxypyridine (CAS: 52311-50-9) and Its Applications in Chemical Biology and Medicine

2-Chloro-4-ethoxypyridine (CAS: 52311-50-9) is a versatile chemical intermediate that has garnered significant attention in the fields of chemical biology and pharmaceutical research. Recent studies have highlighted its potential as a key building block in the synthesis of novel bioactive compounds, particularly in the development of kinase inhibitors and other therapeutic agents. This research brief aims to provide an overview of the latest advancements related to this compound, focusing on its synthesis, biological activity, and applications in drug discovery.

One of the most notable developments in the study of 2-Chloro-4-ethoxypyridine is its role in the synthesis of small-molecule inhibitors targeting specific kinases involved in cancer progression. A 2023 study published in the Journal of Medicinal Chemistry demonstrated that derivatives of this compound exhibit potent inhibitory activity against certain tyrosine kinases, which are often dysregulated in various malignancies. The researchers employed a structure-activity relationship (SAR) approach to optimize the compound's efficacy, leading to the identification of several promising candidates for further preclinical evaluation.

In addition to its applications in oncology, 2-Chloro-4-ethoxypyridine has also been explored as a precursor in the synthesis of antimicrobial agents. A recent report in Bioorganic & Medicinal Chemistry Letters detailed the use of this compound in the development of novel antibiotics targeting multidrug-resistant bacterial strains. The study revealed that modifications to the ethoxy and chloro substituents on the pyridine ring could significantly enhance the compound's antibacterial activity while minimizing cytotoxicity to human cells.

From a synthetic chemistry perspective, advancements in the preparation of 2-Chloro-4-ethoxypyridine have also been reported. A 2022 publication in Organic Process Research & Development described an improved, scalable synthesis route that offers higher yields and reduced environmental impact compared to traditional methods. This development is particularly relevant for industrial-scale production, as it addresses some of the challenges associated with the compound's manufacturing process.

The pharmacological profile of 2-Chloro-4-ethoxypyridine derivatives continues to be an active area of investigation. Recent in vitro and in vivo studies have shed light on the compound's pharmacokinetic properties, including its metabolic stability and membrane permeability. These findings are critical for the design of more effective drug candidates and have prompted further research into structure-optimization strategies.

Looking ahead, the potential applications of 2-Chloro-4-ethoxypyridine appear to be expanding beyond traditional small-molecule therapeutics. Emerging research suggests its utility in the development of targeted drug delivery systems and as a component in chemical probes for studying biological pathways. As the field of chemical biology continues to evolve, this compound is likely to remain a valuable tool for researchers seeking to bridge the gap between chemistry and biology in drug discovery efforts.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)