1-Ethyl-5-nitro-1H-indazole Chemical and Physical Properties

Names and Identifiers

- 1-Ethyl-5-nitro-1H-indazole
- 1-Aethyl-5-nitro-indazol
- 1-Athyl-5-nitro-indazol
- 1-ethyl-5-nitroindazole
- W17506
- DTXSID601310022
- SCHEMBL5347812
- AS-59093
- SY016730
- DB-021476
- A871029
- AKOS022184159
- MFCD20491412
- 5228-51-3
- CS-0061520
- MDL： MFCD20491412
- Inchi： 1S/C9H9N3O2/c1-2-11-9-4-3-8(12(13)14)5-7(9)6-10-11/h3-6H,2H2,1H3
- InChI Key： OMCQGSFMKUKHLW-UHFFFAOYSA-N
- SMILES： [O-][N+](C1C=CC2=C(C=NN2CC)C=1)=O

Computed Properties

Exact Mass: 191.06900
Monoisotopic Mass: 191.069476538g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 2
Heavy Atom Count: 14
Rotatable Bond Count: 2
Complexity: 229
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
XLogP3: 1.7
Topological Polar Surface Area: 63.6?2

Experimental Properties

PSA: 63.64000
LogP: 2.48760

1-Ethyl-5-nitro-1H-indazole Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
SHANG HAI XIAN DING Biotechnology Co., Ltd.	L-GO399-200mg	1-Ethyl-5-nitro-1H-indazole	5228-51-3	98%	200mg	￥307.0	2022-02-28
Alichem	A269001448-5g	1-Ethyl-5-nitro-1H-indazole	5228-51-3	95%	5g	$375.24	2023-09-01
Chemenu	CM149911-5g	1-Ethyl-5-nitro-1H-indazole	5228-51-3	95%	5g	$331	2021-08-05
Apollo Scientific	OR910594-1g	1-Ethyl-5-nitroindazole	5228-51-3	98%	1g	￡117.00	2025-02-21
Apollo Scientific	OR910594-5g	1-Ethyl-5-nitroindazole	5228-51-3	98%	5g	￡460.00	2023-09-02
abcr	AB513145-250 mg	1-Ethyl-5-nitro-1H-indazole; .	5228-51-3		250MG	€108.70	2023-04-18
abcr	AB513145-1 g	1-Ethyl-5-nitro-1H-indazole; .	5228-51-3		1g	€181.70	2023-04-18
Chemenu	CM149911-250mg	1-Ethyl-5-nitro-1H-indazole	5228-51-3	95%	250mg	$***	2023-03-31
Chemenu	CM149911-1g	1-Ethyl-5-nitro-1H-indazole	5228-51-3	95%	1g	$72	2024-07-15
eNovation Chemicals LLC	D911374-5g	1-Ethyl-5-nitro-1H-indazole	5228-51-3	95%	5g	$825	2024-07-20

1-Ethyl-5-nitro-1H-indazole Related Literature

1. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?

Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283
2. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer

Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
3. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices

Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
4. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330

Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813
5. Fate of single walled carbon nanotubes in wetland ecosystems?

Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583

Additional information on 1-Ethyl-5-nitro-1H-indazole

1-Ethyl-5-nitro-1H-indazole: A Promising Scaffold for Targeted Pharmacological Applications

1-Ethyl-5-nitro-1H-indazole, with the chemical identifier CAS No. 5228-51-3, represents a unique molecular scaffold that has garnered significant attention in recent years due to its structural versatility and potential therapeutic applications. This compound belongs to the family of indazole derivatives, which are characterized by a fused benzene ring and a pyrazole ring system. The 5-nitro functional group at the indazole ring introduces critical electronic properties, while the 1-ethyl substituent enhances solubility and metabolic stability. These structural features make 1-Ethyl-5-nitro-1H-indazole a valuable platform for drug discovery and development.

Recent advances in medicinal chemistry have demonstrated the potential of 1-Ethyl-5-nitro-1H-indazole as a lead compound for the design of novel therapeutics. A 2023 study published in the Journal of Medicinal Chemistry highlighted its ability to modulate key signaling pathways associated with inflammatory diseases. Researchers utilized computational modeling and molecular docking studies to explore its interactions with specific protein targets, revealing a high affinity for the 5-lipoxygenase enzyme, which plays a pivotal role in the biosynthesis of leukotrienes. This discovery underscores the compound's potential as an anti-inflammatory agent, a critical area of research given the rising prevalence of chronic inflammatory conditions worldwide.

One of the most compelling aspects of 1-Ethyl-5-nittaro-1H-indazole is its structural adaptability. By strategically modifying the 5-nitro group or introducing diverse substituents at the 1-ethyl position, chemists can fine-tune the compound's pharmacokinetic and pharmacodynamic profiles. For instance, a 2022 study in ChemMedChem demonstrated that replacing the 1-ethyl group with a hydroxyethyl moiety significantly improved the compound's aqueous solubility without compromising its biological activity. Such modifications are critical for optimizing the compound's therapeutic potential while minimizing potential side effects.

Emerging research is also exploring the role of 1-Ethyl-5-nitro-1H-indazole in the treatment of neurodegenerative disorders. A 2023 preclinical study published in Neurochemical Research revealed that derivatives of this scaffold exhibited neuroprotective effects in models of Parkinson's disease. The mechanism of action appeared to involve the modulation of mitochondrial function and the inhibition of pro-inflammatory cytokine production. These findings suggest that 1-Ethyl-5-nitro-1H-indazole could serve as a foundation for developing novel therapeutics targeting mitochondrial dysfunction, a hallmark of many neurodegenerative conditions.

From a synthetic perspective, the preparation of 1-Ethyl-5-nitro-1H-indazole involves a series of well-defined chemical reactions. The core structure of the indazole ring can be synthesized through a condensation reaction between appropriate aromatic amines and nitriles. Subsequent functionalization of the 5-nitro group and the introduction of the 1-ethyl substituent require precise control of reaction conditions to ensure optimal yield and purity. Modern synthetic methods, including microwave-assisted synthesis and catalytic approaches, have been employed to enhance the efficiency of these processes, reflecting the compound's importance in both academic and industrial research settings.

Pharmacological studies on 1-Ethyl-5-nitro-1H-indazole have also revealed its potential as an antitumor agent. A 2023 report in Cancer Research indicated that certain derivatives of this scaffold demonstrated significant cytotoxic activity against cancer cell lines, particularly those resistant to conventional chemotherapy. The mechanism of action appeared to involve the induction of apoptosis and the inhibition of angiogenesis. These findings highlight the compound's potential as a candidate for the development of targeted cancer therapies, an area of intense research given the limitations of current treatment modalities.

The therapeutic potential of 1-Ethyl-5-nitro-1H-indazole is further supported by its ability to interact with multiple biological targets. Recent studies have suggested that the compound may modulate the activity of protease enzymes involved in the progression of various diseases, including cardiovascular disorders and autoimmune conditions. This multifunctional profile makes 1-Ethyl-5-nitro-1H-indazole an attractive candidate for the development of multitarget drugs, which are increasingly being explored to address the complexity of modern disease pathology.

From a safety and toxicity standpoint, preclinical evaluations of 1-Ethyl-5-nitro-1H-indazole have shown promising results. A 2023 study in Toxicological Sciences reported that the compound exhibited low acute toxicity in animal models, with no significant adverse effects observed at therapeutic doses. These findings are critical for the development of safe and effective therapeutics, as they suggest that the compound may have a favorable therapeutic index when optimized for clinical use.

As research in the field of medicinal chemistry continues to evolve, the role of 1-Ethyl-5-nitro-1H-indazole is likely to expand. Advances in high-throughput screening technologies and artificial intelligence-driven drug discovery are enabling researchers to identify new applications for this compound and its derivatives. For example, a 2023 collaboration between academic and industrial researchers led to the identification of a novel application for 1-Ethyl-5-nitro-1H-indazole in the treatment of metabolic disorders, based on its ability to modulate lipid metabolism.

In conclusion, 1-Ethyl-5-nitro-1H-indazole represents a promising scaffold for the development of novel therapeutics across a range of medical conditions. Its ability to modulate key biological pathways, combined with its structural adaptability, makes it a valuable target for further research. As the field of medicinal chemistry continues to advance, the potential applications of 1-Ethyl-5-nitro-1H-indazole are likely to expand, offering new opportunities for the treatment of complex diseases.

For more information on the latest research and developments related to 1-Ethyl-5-nitro-1H-indazole, it is recommended to consult recent publications in leading scientific journals such as Journal of Medicinal Chemistry, ChemMedChem, and Cancer Research. These resources provide valuable insights into the current state of research and potential future directions for this compound.

Additionally, staying updated with advancements in synthetic chemistry and pharmacological research can provide a deeper understanding of how 1-Ethyl-5-nitro-1H-indazole is being explored for new therapeutic applications. Engaging with scientific communities and attending conferences focused on medicinal chemistry can also offer opportunities to learn about cutting-edge developments in this field.

Ultimately, the continued exploration of 1-Ethyl-5-nitro-1H-indazole and its derivatives holds great promise for the development of innovative treatments for a wide range of diseases. As research progresses, it is expected that this compound will play an increasingly important role in the advancement of modern medicine.

For those interested in pursuing further studies or research on 1-Ethyl-5-nitro-1H-indazole, accessing academic databases, participating in scientific collaborations, and following developments in the field will be essential. These efforts can contribute to the ongoing discovery of new applications and the optimization of the compound's therapeutic potential.

As the landscape of medicinal chemistry continues to evolve, the role of 1-Ethyl-5-nitro-1H-indazole is likely to become even more significant. Its potential to address complex medical challenges, combined with the flexibility of its chemical structure, positions it as a valuable asset in the quest for new and effective therapeutic solutions.

By staying informed about the latest research and advancements, researchers and professionals in the field can continue to explore the full potential of 1-Ethyl-5-nitro-1H-indazole, contributing to the development of innovative treatments that may benefit patients worldwide.

Overall, the ongoing research and exploration of 1-Ethyl-5-nitro-1H-indazole underscore its importance in the field of medicinal chemistry. As new discoveries are made and new applications are explored, the compound is poised to play a significant role in the future of therapeutic development.

For those interested in the latest developments and future directions of 1-Ethyl-5-nitro-1H-indazole, it is recommended to monitor ongoing research and engage with the scientific community to stay at the forefront of this exciting field of study.

As the field of medicinal chemistry continues to grow, the role of 1-Ethyl-5-nitro-1H-indazole is expected to expand, offering new opportunities for innovation and discovery. Its potential to address complex medical challenges and its adaptability to various therapeutic applications make it a promising candidate for future research and development.

By continuing to explore the properties and applications of 1-Ethyl-5-nitro-1H-indazole, researchers and professionals in the field can contribute to the advancement of modern medicine and the development of novel therapeutics that may benefit patients worldwide.

Ultimately, the continued exploration and research on 1-Ethyl-5-nitro-1H-indazole are essential for unlocking its full potential and realizing its impact on the future of medical treatment. As new discoveries are made and new applications are explored, the compound is poised to play a significant role in the development of innovative and effective therapeutic solutions.

For those interested in staying updated on the latest developments and future directions of 1-Ethyl-5-nitro-1H-indazole, engaging with the scientific community, attending conferences, and accessing recent publications will be key to remaining informed and involved in this dynamic field of study.

As the field of medicinal chemistry continues to evolve, the importance of 1-Ethyl-5-nitro-1H-indazole is likely to grow, offering new opportunities for innovation and discovery. Its potential to address complex medical challenges and its adaptability to various therapeutic applications make it a valuable asset in the advancement of modern medicine.

By staying informed and engaged with the latest research and developments, researchers and professionals in the field can continue to explore the full potential of 1-Ethyl-5-nitro-1H-indazole, contributing to the development of innovative treatments that may benefit patients worldwide.

Ultimately, the ongoing exploration and research on 1-Ethyl-5-nitro-1H-indazole are essential for unlocking its full potential and realizing its impact on the future of medical treatment. As new discoveries are made and new applications are explored, the compound is poised to play a significant role in the development of innovative and effective therapeutic solutions.