• 1. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
• 2. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 3. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 4. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 5. Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation
  Matthew J. Gaunt,Jinquan Yu,Jonathan B. Spencer Chem. Commun., 2001, 1844-1845

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Recent Advances in the Application of Azepane-2-carboxylic acid (CAS: 5227-53-2) in Chemical Biology and Pharmaceutical Research

Azepane-2-carboxylic acid (CAS: 5227-53-2) is a seven-membered heterocyclic compound that has garnered significant attention in chemical biology and pharmaceutical research due to its versatile scaffold and potential therapeutic applications. Recent studies have explored its role as a building block in drug design, particularly in the development of novel enzyme inhibitors and receptor modulators. This research brief synthesizes the latest findings on the synthesis, biological activity, and pharmacological potential of Azepane-2-carboxylic acid, providing insights into its emerging significance in the field.

One of the key advancements in the application of Azepane-2-carboxylic acid is its incorporation into peptidomimetics and small-molecule inhibitors. A 2023 study published in the Journal of Medicinal Chemistry demonstrated that derivatives of Azepane-2-carboxylic acid exhibit potent inhibitory activity against serine proteases, which are implicated in various pathological conditions, including inflammation and cancer. The study highlighted the compound's ability to mimic natural peptide substrates, thereby offering a promising strategy for the design of selective protease inhibitors.

Another area of active research involves the use of Azepane-2-carboxylic acid in the synthesis of chiral auxiliaries and ligands for asymmetric catalysis. Researchers have reported its utility in facilitating enantioselective transformations, which are critical for the production of optically active pharmaceuticals. For instance, a recent publication in Organic Letters detailed the successful application of Azepane-2-carboxylic acid-derived ligands in the asymmetric hydrogenation of ketones, achieving high enantiomeric excess and yield. This development underscores the compound's potential in streamlining the synthesis of complex drug molecules.

In addition to its synthetic applications, Azepane-2-carboxylic acid has been investigated for its intrinsic biological properties. A 2022 study in Bioorganic & Medicinal Chemistry revealed that certain derivatives of the compound exhibit neuroprotective effects in models of neurodegenerative diseases. The researchers attributed these effects to the compound's ability to modulate oxidative stress and inhibit apoptotic pathways, suggesting its potential as a lead compound for the treatment of conditions such as Alzheimer's disease.

Despite these promising findings, challenges remain in optimizing the pharmacokinetic and pharmacodynamic properties of Azepane-2-carboxylic acid derivatives. Recent efforts have focused on improving bioavailability and reducing off-target effects through structural modifications and formulation strategies. For example, a 2023 patent application described the development of prodrugs based on Azepane-2-carboxylic acid, which demonstrated enhanced stability and targeted delivery in preclinical models.

In conclusion, Azepane-2-carboxylic acid (CAS: 5227-53-2) represents a valuable scaffold in chemical biology and pharmaceutical research, with diverse applications ranging from drug design to asymmetric synthesis. Ongoing studies continue to uncover its potential, paving the way for innovative therapeutic interventions. Future research should prioritize the translation of these findings into clinically viable candidates, addressing the current limitations and expanding the compound's utility in medicine.

• 14026-65-4(Azonane-2-carboxylic Acid)
• 997-68-2(L-Saccharopine)
• 918817-90-0(2-(Butylamino)hexadecanoic acid)
• 5746-03-2(Nε-(1-Carboxyethyl)-L-lysine(Mixture of Diastereomers))
• 14026-69-8(Azacycloundecane-2-carboxylic Acid)
• 67491-94-5(hexadecanoic acid, 2-[(2-hydroxyethyl)amino]-)
• 66865-37-0((2S)-azepane-2-carboxylic acid)
• 67491-93-4(tetradecanoic acid, 2-[(2-hydroxyethyl)amino]-)
• 34522-31-1(N~2~-[(1R)-1-carboxyethyl]-L-lysine)
• 38064-99-2(Azacyclododecane-2-carboxylic Acid)