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  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 2. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?
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  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
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• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Comprehensive Overview of 3-(2-Bromo-phenyl)-propan-1-OL (CAS No. 52221-92-8): Properties, Applications, and Industry Insights

3-(2-Bromo-phenyl)-propan-1-OL (CAS No. 52221-92-8) is a specialized organic compound featuring a brominated aromatic core linked to a propanol side chain. This structure grants it unique physicochemical properties, making it valuable in pharmaceutical intermediates, material science, and fine chemical synthesis. With a molecular formula of C₉H₁₁BrO, it exhibits a balance of reactivity and stability, often exploited in cross-coupling reactions and catalysis.

Recent trends highlight growing interest in bromo-substituted compounds due to their versatility in drug discovery and agrochemical development. Researchers frequently search for "3-(2-Bromo-phenyl)-propan-1-OL synthesis" or "CAS 52221-92-8 applications," reflecting demand for scalable production methods and novel uses. The compound’s aryl bromide moiety is pivotal in palladium-catalyzed reactions, such as Suzuki-Miyaura couplings, aligning with the push for greener chemistry.

From a material science perspective, 52221-92-8 serves as a precursor for liquid crystals and polymeric additives. Its hydroxyl group enables derivatization into esters or ethers, expanding utility in coatings and adhesives. Industry reports emphasize its role in high-performance polymers, answering queries like "how to modify 3-(2-Bromo-phenyl)-propan-1-OL for polymers."

Environmental and regulatory considerations are also trending. While not classified as hazardous, users often seek "CAS 52221-92-8 safety data" or "biodegradability of bromo-aromatics." Manufacturers prioritize sustainable bromination methods to reduce waste, resonating with green chemistry initiatives. Analytical techniques like HPLC and NMR ensure purity, addressing quality concerns in GMP-compliant production.

In pharmaceutical research, 3-(2-Bromo-phenyl)-propan-1-OL is explored for bioactive molecule scaffolds. Its structural motif appears in studies targeting CNS disorders and anti-inflammatory agents, responding to searches such as "bromo-phenyl derivatives in medicine." Patent analyses reveal its inclusion in proprietary formulations, underscoring commercial potential.

Supply chain dynamics further elevate its relevance. Global suppliers face queries like "where to buy 52221-92-8" or "bulk pricing for 3-(2-Bromo-phenyl)-propan-1-OL." Stable sourcing is critical, especially amid shifts in bromine market pricing. Storage recommendations (2-8°C, inert atmosphere) and handling protocols are frequently documented to ensure longevity.

Innovation continues to drive interest. Recent publications describe nanocatalysis approaches to synthesize 52221-92-8 with higher yields, answering "how to improve bromo-phenyl propanol efficiency." As industries prioritize molecular diversity, this compound’s adaptability ensures sustained relevance in R&D pipelines worldwide.

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