• 1. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
• 2. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
  Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644
• 3. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 4. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 5. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699

1-(Benzo[d][1,3]dioxol-5-yl)-2-bromopropan-1-one: A Comprehensive Overview

The compound 1-(Benzo[d][1,3]dioxol-5-yl)-2-bromopropan-1-one, with CAS No. 52190-28-0, is a highly specialized organic molecule that has garnered significant attention in the fields of organic chemistry and pharmacology. This compound is notable for its unique structural features and its potential applications in drug discovery and synthesis. The molecule consists of a benzo[d][1,3]dioxole ring system, which is fused with a brominated propanone group, creating a structure that exhibits both aromaticity and electrophilic properties.

Recent studies have highlighted the importance of benzo[d][1,3]dioxole derivatives in medicinal chemistry. These compounds are known to possess various bioactive properties, including antioxidant, anti-inflammatory, and anticancer activities. The presence of the bromine atom in the propanone group further enhances the molecule's reactivity, making it a valuable intermediate in organic synthesis. Researchers have explored the use of 1-(Benzo[d][1,3]dioxol-5-yl)-2-bromopropan-1-one in the development of novel therapeutic agents targeting chronic diseases such as cancer and neurodegenerative disorders.

The synthesis of 1-(Benzo[d][1,3]dioxol-5-yl)-2-bromopropan-1-one involves a multi-step process that typically begins with the preparation of the benzo[d][1,3]dioxole ring system. This is often achieved through the cyclization of substituted resorcinols under acidic conditions. Once the dioxole ring is formed, it undergoes further functionalization to introduce the brominated propanone group. The reaction conditions and reagents used in this process are critical to ensuring high yields and purity of the final product.

One of the most promising applications of this compound lies in its use as a building block for more complex molecules. By leveraging its reactivity and structural versatility, chemists can construct libraries of compounds with diverse biological activities. For instance, recent research has demonstrated that derivatives of 1-(Benzo[d][1,3]dioxol-5-yl)-2-bromopropan-1-one can modulate key cellular pathways involved in cancer progression. These findings underscore the potential of this compound as a lead molecule for drug development.

In addition to its role in medicinal chemistry, 1-(Benzo[d][1,3]dioxol-5-yl)-2-bromopropan-1-one has also been studied for its electronic properties. The combination of aromaticity and electrophilicity makes it an interesting candidate for applications in materials science. Researchers have explored its use as a precursor for organic semiconductors and optoelectronic materials. Initial results suggest that derivatives of this compound could exhibit desirable electronic characteristics for use in next-generation devices.

The growing interest in 1-(Benzo[d][1,3]dioxol-5-yl)-2-bromopropan-1-one has led to increased scrutiny regarding its safety and environmental impact. While preliminary data indicate that this compound is not inherently hazardous under normal handling conditions, further studies are needed to fully characterize its toxicity profile. Regulatory agencies have emphasized the importance of conducting thorough risk assessments for all new chemical entities to ensure their safe use in industrial and research settings.

In conclusion, 1-(Benzo[d][1,3]dioxol-5-yl)-2-bromopropan-1-one (CAS No. 52190-28) represents a significant advancement in organic chemistry due to its unique structure and diverse applications. Its role as an intermediate in drug discovery and materials science highlights its importance as a versatile building block for future innovations. As research continues to uncover new insights into its properties and potential uses, this compound is poised to make a lasting impact across multiple disciplines.

• 83963-15-9(1-Propanone,1-(1,3-benzodioxol-5-yl)-2-bromo-)
• 52190-29-1(2-bromo-1-(3,4,5-trimethoxyphenyl)propan-1-one)
• 21726-71-6(1-Propanone,2-bromo-1-(3-methoxyphenyl)-)
• 783321-45-9(Ethanone, 1-(1,3-benzodioxol-5-yl)-2,2-dibromo-)
• 40288-65-1(1-(2H-1,3-benzodioxol-5-yl)-2-bromoethan-1-one)
• 66659-96-9(Ethanone, 2-bromo-1-(3,4-dimethoxyphenyl)-2-phenyl-)
• 146721-06-4((+/-)-1-(1,3-Benzodioxol-5-yl)-2-broMo-1-pentanone)
• 1835-05-8(2-Bromo-1-(3,4-dimethoxyphenyl)propan-1-one)
• 594810-92-1(Ethanone, 1-(1,3-benzodioxol-4-yl)-2-bromo-)
• 63828-97-7(1-Dodecanone, 2-bromo-1-(3,4-dimethoxyphenyl)-)