Cas no 52-70-0 (6a,9a-Difluoroprednisolone 21-Acetate)

6a,9a-Difluoroprednisolone 21-Acetate is a synthetic glucocorticoid derivative characterized by the introduction of fluorine atoms at the 6a and 9a positions, along with an acetate ester at the 21-hydroxyl group. These structural modifications enhance its anti-inflammatory and immunosuppressive potency compared to non-fluorinated corticosteroids. The fluorination improves receptor binding affinity and metabolic stability, while the 21-acetate group contributes to prolonged activity. This compound is primarily used in research settings to study glucocorticoid receptor interactions and corticosteroid pharmacology. Its well-defined structure makes it a valuable reference standard for analytical and biochemical applications. Careful handling is advised due to its potent biological activity.
6a,9a-Difluoroprednisolone 21-Acetate structure
52-70-0 structure
Product Name:6a,9a-Difluoroprednisolone 21-Acetate
CAS No:52-70-0
MF:C23H28F2O6
MW:438.461634635925
CID:376152
PubChem ID:101528
Update Time:2025-06-07

6a,9a-Difluoroprednisolone 21-Acetate Chemical and Physical Properties

Names and Identifiers

    • Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-6,9-difluoro-11,17-dihydroxy-, (6a,11b)- (9CI)
    • 6α,?9α-?Difluoroprednisolone 21-Acetate
    • (6α,11β)-6,9-Difluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-2 1-yl acetate
    • 6alpha,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate
    • 6Α,?9Α-?DIFLUOROPREDNISOLONE 21-ACETATE
    • (6alpha,11beta)-6,9-difluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate
    • 200-150-9
    • Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,17,21-trihydroxy-, 21-acetate
    • DTXSID90966323
    • 6alpha,9alpha-Difluoroprednisolone 21-acetate
    • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11,17-dihydroxy-, (6alpha,11beta)-
    • (6A,11BETA)-21-(ACETYLOXY)-6,9-DIFLUORO-11,17-DIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE
    • CHEMBL3250151
    • (6
    • 6a,?9a-?Difluoroprednisolone 21-Acetate
    • C15920
    • A)-21-(Acetyloxy)-6,9-difluoro-11,17-dihydroxypregna-1,4-diene-3,20-dione
    • 953PJH8Y9L
    • (6alpha,11beta)-21-(Acetyloxy)-6,9-difluoro-11,17-dihydroxypregna-1,4-diene-3,20-dione
    • 52-70-0
    • 6,9-Difluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate
    • A,11
    • SCHEMBL15501297
    • EINECS 200-150-9
    • NS00041160
    • [2-[(6S,8S,9R,10S,11S,13S,14S,17R)-6,9-difluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
    • (6a,11ss)-21-(Acetyloxy)-6,9-difluoro-11,17-dihydroxypregna-1,4-diene-3,20-dione; 6a,9-Difluoro-11ss,17,21-trihydroxypregna-1,4-diene-3,20-dione;
    • 6a,9a-Difluoroprednisolone 21-Acetate
    • Inchi： 1S/C23H28F2O6/c1-12(26)31-11-19(29)22(30)7-5-14-15-9-17(24)16-8-13(27)4-6-20(16,2)23(15,25)18(28)10-21(14,22)3/h4,6,8,14-15,17-18,28,30H,5,7,9-11H2,1-3H3/t14-,15-,17-,18-,20-,21-,22-,23-/m0/s1
    • InChI Key： LAAFISZDLHQNFS-WGFKBPOKSA-N
    • SMILES： F[C@@]12[C@]3(C=CC(C=C3[C@H](C[C@H]1[C@@H]1CC[C@](C(COC(C)=O)=O)([C@@]1(C)C[C@@H]2O)O)F)=O)C

Computed Properties

  • Exact Mass: 438.18544
  • Monoisotopic Mass: 438.185
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 8
  • Heavy Atom Count: 31
  • Rotatable Bond Count: 4
  • Complexity: 914
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 8
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2
  • Topological Polar Surface Area: 101A^2

Experimental Properties

  • Density: 1.35
  • Boiling Point: 578.1°Cat760mmHg
  • Flash Point: 303.4°C
  • Refractive Index: 1.566
  • PSA: 100.9
  • LogP: 2.16850

6a,9a-Difluoroprednisolone 21-Acetate Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
D446325-25mg
6a,?9a-?Difluoroprednisolone 21-Acetate
 52-70-0
25mg
 $ 228.00 2023-09-07
TRC
D446325-250mg
6a,?9a-?Difluoroprednisolone 21-Acetate
 52-70-0
250mg
 $ 1696.00 2023-09-07
SHENG KE LU SI SHENG WU JI SHU
sc-499596-25mg
6α,9α-Difluoroprednisolone 21-Acetate,
 52-70-0
25mg
 ￥2858.00 2023-09-05
SHENG KE LU SI SHENG WU JI SHU
sc-499596-25 mg
6α,9α-Difluoroprednisolone 21-Acetate,
 52-70-0
25mg
 ￥2,858.00 2023-07-11

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