• 1. Alternative mixtures to R-600a. Theoretical assessment and experimental energy evaluation of binary mixtures in a commercial cooler: Mélanges alternatifs au R-600a. évaluation théorique et évaluation énergétique expérimentale de mélanges binaires dans un refroidisseur commercial.
  DanielCalleja-Anta,DanielSánchez,LauraNebot-Andres,RamónCabello,RodrigoLlopis
• 2. Aggregation-induced emission leading to two distinct emissive species in the solid-state structure of high-dipole organic chromophores?
  Felix Witte,Philipp Rietsch,Nithiya Nirmalananthan-Budau,Florian Weigert,Jan P. G?tze,Ute Resch-Genger,Siegfried Eigler,Beate Paulus Phys. Chem. Chem. Phys., 2021,23, 17521-17529
• 3. An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes?
  H. V. Jain,D. Verthelyi,S. L. Beaucage RSC Adv., 2017,7, 42519-42528
• 4. Alt-proteins: A promising future
• 5. An approach to biodegradable star polymeric architectures using disulfide coupling?
  Jingquan Liu,Huiyun Liu,Zhongfan Jia,Volga Bulmus,Thomas P. Davis Chem. Commun., 2008, 6582-6584

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Fluorobenzenes

Methyl 5-(4-fluorophenyl)-1,2-oxazole-3-carboxylate (CAS No. 517870-16-5): A Comprehensive Overview

Methyl 5-(4-fluorophenyl)-1,2-oxazole-3-carboxylate (CAS No. 517870-16-5) is a heterocyclic compound that has garnered significant attention in the field of pharmaceutical chemistry due to its unique structural properties and potential biological activities. This compound belongs to the oxazole class of molecules, which are known for their broad spectrum of biological interactions. The presence of a fluorophenyl substituent in its structure enhances its pharmacological profile, making it a valuable scaffold for drug discovery and development.

The chemical structure of methyl 5-(4-fluorophenyl)-1,2-oxazole-3-carboxylate consists of an oxazole ring fused with a carboxylate group and a fluorinated aromatic ring. This arrangement imparts specific electronic and steric properties that can influence its interactions with biological targets. The fluorine atom in the 4-fluorophenyl moiety is particularly noteworthy, as fluorine substitution often enhances metabolic stability and binding affinity in drug molecules.

In recent years, there has been a growing interest in oxazole derivatives as potential therapeutic agents. Oxazoles are five-membered heterocycles containing one oxygen and two carbon atoms, and they exhibit a wide range of biological activities, including antimicrobial, anti-inflammatory, and anticancer properties. The incorporation of a fluorophenyl group into the oxazole core further modulates its pharmacological effects, making it an attractive candidate for further investigation.

One of the most compelling aspects of methyl 5-(4-fluorophenyl)-1,2-oxazole-3-carboxylate is its potential as a lead compound for the development of novel drugs. Researchers have been exploring its biological activity by evaluating its interactions with various enzymes and receptors. Preliminary studies suggest that this compound may exhibit inhibitory effects on certain kinases and other targets relevant to cancer therapy. These findings align with the broader trend in medicinal chemistry towards designing molecules with multiple functional groups to enhance their therapeutic potential.

The synthesis of methyl 5-(4-fluorophenyl)-1,2-oxazole-3-carboxylate involves multi-step organic reactions that require careful optimization to ensure high yield and purity. The key steps typically include the formation of the oxazole ring followed by functionalization with the fluorophenyl substituent and the carboxylate group. Advanced synthetic techniques such as palladium-catalyzed cross-coupling reactions have been employed to achieve regioselective modifications of the oxazole core.

The role of computational chemistry in the study of methyl 5-(4-fluorophenyl)-1,2-oxazole-3-carboxylate cannot be overstated. Molecular modeling techniques have been used to predict the binding modes of this compound with potential biological targets. These simulations provide valuable insights into the interactions between the molecule and its targets, helping to guide the design of more effective derivatives.

In addition to its pharmaceutical applications, methyl 5-(4-fluorophenyl)-1,2-oxazole-3-carboxylate has shown promise in material science. Its unique structural features make it a suitable candidate for developing novel materials with specific optical and electronic properties. For instance, researchers have explored its use in organic light-emitting diodes (OLEDs) due to its ability to undergo efficient energy transfer and emission.

The future directions for research on methyl 5-(4-fluorophenyl)-1,2-oxazole-3-carboxylate are multifaceted. Further investigation into its biological activity is warranted to identify new therapeutic applications. Additionally, exploring synthetic pathways that improve yield and sustainability will be crucial for large-scale production. Collaborative efforts between synthetic chemists and biologists will be essential to fully realize the potential of this compound.

In conclusion, methyl 5-(4-fluorophenyl)-1,2-oxazole-3-carboxylate (CAS No. 517870-16-5) is a versatile compound with significant implications in pharmaceutical chemistry and material science. Its unique structure and functional groups make it an attractive scaffold for drug discovery and development. As research continues to uncover new applications for this molecule, it is likely to play an increasingly important role in addressing various scientific and medical challenges.

• 33282-24-5(5-(4-fluorophenyl)-1,2-oxazole-3-carboxylic acid)
• 7063-99-2(Ethyl 5-phenylisoxazole-3-carboxylate)
• 377052-00-1(Ethyl 5-(4-fluorophenyl)isoxazole-3-carboxylate)
• 640291-92-5(ethyl 5-(4-fluorophenyl)isoxazole-3-carboxylate)
• 88958-15-0(Ethyl 5-(p-tolyl)isoxazole-3-carboxylate)
• 934188-80-4( )
• 371157-14-1(3-Isoxazolecarboxylicacid, 5-(3-fluorophenyl)-, ethyl ester)
• 51677-09-9(methyl 5-phenyl-1,2-oxazole-3-carboxylate)
• 885958-97-4(5-(3,5-difluorophenyl)-1,2-oxazole-3-carboxylic acid)
• 1105191-49-8(methyl 5-(2,4-difluorophenyl)-1,2-oxazole-3-carboxylate)