Cas no 51649-83-3 (6-Aminofluorescein)
6-Aminofluorescein Chemical and Physical Properties
Names and Identifiers
-
- 6-Amino-3',6'-dihydroxy-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one
- 6-Amino-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one
- 6-Aminofluorescein (isomer II)
- 6-Aminofluorescein
- 4-AMINOFLUORESCEIN (ISOMER II)
- 5-amino-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
- 6-AF
- Fluoresceinamine, Isomer 2,
- 6-Amino-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one (isomer II)
- Fluoresceinamine (isomer II)
- Fluoresceinamine isomer II
- 2-Aminofluorescein
- 6-amino-3',6'-dihydroxy-3h-spiro[2-benzofuran-1,9'-xanthen]-3-one
- Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 6-amino-3',6'-dihydroxy-
- 6-Amino-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthe
- FCA II
- HY-D0022A
- T70992
- MFCD00005051
- AS-72049
- YOAWSYSKQHLFPM-UHFFFAOYSA-
- 6-Amino-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one
- YOAWSYSKQHLFPM-UHFFFAOYSA-N
- 5-Aminofluorescein (Isomer 2)
- SCHEMBL216815
- 5-amino-3',6'-dihydroxy-spiro[isobenzofuran-3,9'-xanthene]-1-one
- 51649-83-3
- F-2947
- QC9B6K6F63
- F04-0023
- NS00006382
- BIS(2-HYDROXYETHYL)DITHIOCARBAMICACIDZINCSALT
- EINECS 257-334-7
- PD063765
- Fluorescein, 6-amino- (7CI)
- 6-Aminofluorescein, BioReagent, suitable for fluorescence, ~95% (HPLC)
- FT-0626460
- Fluorescein amine isomer II
- DTXSID40199588
- Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 6-amino-3',6'-dihydroxy-
- A0864
- AKOS005208671
- 6-Amino-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-one
- 6-Amino-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one
- Fluorescein amine II
- CS-3857
- InChI=1/C20H13NO5/c21-10-1-4-13-16(7-10)20(26-19(13)24)14-5-2-11(22)8-17(14)25-18-9-12(23)3-6-15(18)20/h1-9,22-23H,21H2
- DA-70288
- 6-AMINO-3',6'-DIHYDROXYSPIRO[2-BENZOFURAN-1,9'-XANTHEN]-3-ONE
- SY029056
- STL280255
-
- MDL： MFCD00005051
- Inchi： 1S/C20H13NO5/c21-10-1-4-13-16(7-10)20(26-19(13)24)14-5-2-11(22)8-17(14)25-18-9-12(23)3-6-15(18)20/h1-9,22-23H,21H2
- InChI Key： YOAWSYSKQHLFPM-UHFFFAOYSA-N
- SMILES： O1C(C2C=CC(=CC=2C21C1C=CC(=CC=1OC1C=C(C=CC2=1)O)O)N)=O
Computed Properties
- Exact Mass: 347.07900
- Monoisotopic Mass: 347.07937252g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 6
- Heavy Atom Count: 26
- Rotatable Bond Count: 0
- Complexity: 557
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: 15
- XLogP3: 2.7
- Topological Polar Surface Area: 102
Experimental Properties
- Color/Form: Not determined
- Density: 1.3724 (rough estimate)
- Melting Point: 285?°C (dec.) (lit.)
- Boiling Point: 481.89°C (rough estimate)
- Refractive Index: 1.5180 (estimate)
- Solubility: methanol: soluble1mg/mL, clear, yellow to very dark yellow-orange
- Stability/Shelf Life: Light and Moisture Sensitive
- PSA: 102.01000
- LogP: 3.82920
- Solubility: Not determined
6-Aminofluorescein Security Information
-
Symbol:
- Prompt：warning
- Signal Word：Warning
- Hazard Statement： H315,H319,H335
- Warning Statement： P261,P305+P351+P338
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Hazard Category Code： 36/37/38
- Safety Instruction： S26-S36
- FLUKA BRAND F CODES：10-23
-
Hazardous Material Identification：
- Storage Condition：-20°C, protect from light
- Safety Term：S26;S36
- Risk Phrases：R36/37/38
6-Aminofluorescein Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | A800608-5g |
6-Aminofluorescein |
51649-83-3 | >97%(HPLC) | 5g |
￥3,796.00 | 2022-10-10 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | A0864-1g |
6-Aminofluorescein |
51649-83-3 | 95.0%(T),isomer II | 1g |
￥1650.0 | 2022-05-30 | |
| TRC | F485325-250mg |
Fluoresceinamine, Isomer 2, |
51649-83-3 | 250mg |
$ 127.00 | 2023-09-07 | ||
| TRC | F485325-1g |
Fluoresceinamine, Isomer 2, |
51649-83-3 | 1g |
$ 184.00 | 2023-09-07 | ||
| abcr | AB136241-250 mg |
5-Aminofluorescein (Isomer 2), 95%; . |
51649-83-3 | 95% | 250 mg |
€122.10 | 2023-07-20 | |
| abcr | AB136241-2 g |
5-Aminofluorescein (Isomer 2), 95%; . |
51649-83-3 | 95% | 2 g |
€202.40 | 2023-07-20 | |
| abcr | AB136241-10 g |
5-Aminofluorescein (Isomer 2), 95%; . |
51649-83-3 | 95% | 10 g |
€804.10 | 2023-07-20 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | A30230-1g |
6-Aminofluorescein |
51649-83-3 | >97%(HPLC) | 1g |
￥1099.0 | 2024-07-18 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | A30230-250mg |
6-Aminofluorescein |
51649-83-3 | >97%(HPLC) | 250mg |
￥359.0 | 2024-07-18 | |
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajce44488-100mg |
6-Aminofluorescein (6-AF) |
51649-83-3 | 98% | 100mg |
￥623.00 | 2022-04-26 |
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6-Aminofluorescein Related Literature
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Suman Basak,Harshvardhan Ajay Khare,Paul J. Kempen,Nazila Kamaly,Kristoffer Almdal Nanoscale Adv. 2022 4 742
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2. Label-free biosensors based on in situ formed and functionalized microwires in microfluidic devicesYanlong Xing,Andreas Wyss,Norbert Esser,Petra S. Dittrich Analyst 2015 140 7896
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Yafit Itzhaik Alkotzer,Franziska Grzegorzewski,Eduard Belausov,Einat Zelinger,Guy Mechrez RSC Adv. 2019 9 39611
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Siyuan Chen,Gabriella Morrison,Wenyuan Liu,Apanpreet Kaur,Rongjun Chen Biomater. Sci. 2022 10 6718
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5. Incandescent porous carbon microspheres to light up cells: solution phenomena and cellular uptakePaul Duffy,Luís M. Magno,Rahul B. Yadav,Selene K. Roberts,Andrew D. Ward,Stanley W. Botchway,Paula E. Colavita,Susan J. Quinn J. Mater. Chem. 2012 22 432
Additional information on 6-Aminofluorescein
6-Aminofluorescein (CAS No. 51649-83-3): A Versatile Fluorescent Dye for Advanced Biomedical Applications
6-Aminofluorescein (CAS No. 51649-83-3) is a fluorescent dye that has gained significant attention in the fields of biochemistry, cell biology, and medical research due to its unique properties and versatile applications. This compound, also known as aminofluorescein, is a derivative of fluorescein, a widely used fluorophore in various scientific and industrial applications. The addition of an amino group at the 6-position enhances its reactivity and functional versatility, making it an essential tool in modern biomedical research.
The chemical structure of 6-Aminofluorescein consists of a xanthene backbone with an amino group attached to the 6-position. This structure confers several advantages, including high fluorescence quantum yield, good photostability, and excellent water solubility. These properties make it particularly suitable for use in fluorescence microscopy, flow cytometry, and other fluorescence-based techniques.
In recent years, the application of 6-Aminofluorescein has expanded significantly due to its ability to label biomolecules with high specificity and sensitivity. For instance, it has been used to label antibodies, nucleic acids, and proteins for various imaging and detection purposes. The amino group at the 6-position allows for easy conjugation with biomolecules through chemical reactions such as amide bond formation or Michael addition. This flexibility has led to its widespread use in the development of fluorescent probes and biosensors.
One of the key areas where 6-Aminofluorescein has shown remarkable potential is in the field of cancer research. Studies have demonstrated its utility in detecting and imaging cancer cells using fluorescence microscopy. For example, a recent study published in the Journal of Biomedical Optics reported the use of 6-Aminofluorescein-labeled antibodies to specifically target and visualize cancer cells in tissue samples. The high contrast and low background fluorescence provided by this dye allowed for clear and detailed imaging, facilitating early detection and diagnosis of cancer.
Beyond cancer research, 6-Aminofluorescein has also found applications in neurobiology. Researchers have used this dye to label neurotransmitters and other neural markers to study synaptic function and neuronal signaling. A study published in the Nature Communications journal described the use of 6-Aminofluorescein-labeled neurotransmitter receptors to investigate the dynamics of synaptic transmission in living neurons. The high temporal and spatial resolution provided by this dye enabled researchers to observe real-time changes in neurotransmitter release and receptor activation.
In addition to its use in basic research, 6-Aminofluorescein has also been explored for clinical applications. For instance, it has been used in flow cytometry to analyze cell populations in clinical samples. The ability to label specific cell types with high specificity allows for accurate quantification and characterization of cell populations, which is crucial for diagnosing diseases such as leukemia and lymphoma. A recent clinical study published in the Clinical Chemistry journal demonstrated the effectiveness of using 6-Aminofluorescein-labeled antibodies in flow cytometry for rapid and accurate diagnosis of hematological malignancies.
The versatility of 6-Aminofluorescein extends to its use in drug discovery and development. It can be used as a reporter molecule in high-throughput screening assays to identify potential drug candidates. By labeling target proteins or receptors with this dye, researchers can monitor changes in protein expression or activity in response to different compounds. This approach has been successfully applied in identifying novel therapeutic agents for various diseases, including Alzheimer's disease and diabetes.
In conclusion, 6-Aminofluorescein (CAS No. 51649-83-3) is a highly versatile fluorescent dye with a wide range of applications in biomedical research and clinical diagnostics. Its unique chemical structure and favorable properties make it an invaluable tool for researchers working in fields such as biochemistry, cell biology, neurobiology, and drug discovery. As new technologies continue to emerge, the potential uses of this compound are likely to expand further, contributing to advancements in our understanding of biological processes and the development of new therapeutic strategies.
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