• 1. An amplified fluorescence detection of T4 polynucleotide kinase activity based on coupled exonuclease III reaction and a graphene oxide platform?
  Ni-Na Sun,Fengli Qu,Xiaobing Zhang,Shufang Zhang,Jinmao You Analyst, 2015,140, 1827-1831
• 2. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003
• 3. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
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• 4. An anti-leakage liquid metal thermal interface material
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• 5. An approach towards the synthesis of novel fused nitrogen tricyclic heterocyclic scaffolds via GBB reaction?
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• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Fatty acids and conjugates Halogenated fatty acids

Comprehensive Guide to 2-Bromopentanedioic Acid (CAS No. 51528-22-4): Properties, Applications, and Industry Insights

2-Bromopentanedioic Acid (CAS No. 51528-22-4), a versatile brominated dicarboxylic acid, has garnered significant attention in organic synthesis and pharmaceutical research. This compound, also known as 2-Bromo-glutaric acid, serves as a critical intermediate in the production of fine chemicals, agrochemicals, and specialty polymers. Its unique molecular structure—featuring a bromine atom at the alpha position—enables selective functionalization, making it invaluable for asymmetric synthesis and chiral building blocks.

Recent trends in green chemistry have amplified interest in sustainable bromination methods for compounds like 2-Bromopentanedioic Acid. Researchers are exploring eco-friendly catalysts and solvent-free reactions to minimize environmental impact while maintaining high yields. This aligns with the growing demand for biodegradable intermediates in industries ranging from pharmaceuticals to materials science.

The physicochemical properties of 51528-22-4 contribute to its broad utility. With a molecular weight of 211.0 g/mol and two carboxylic acid groups, it exhibits excellent water solubility—a key advantage for aqueous-phase reactions. The bromine substituent enhances its reactivity in nucleophilic substitution reactions, particularly in the synthesis of heterocyclic compounds used in drug development.

In pharmaceutical applications, 2-Bromo-glutaric acid derivatives show promise as precursors for enzyme inhibitors and metabolic modulators. Recent studies highlight its role in developing compounds targeting neurodegenerative diseases, a hot topic in medical research. The compound's ability to form stable metal-organic frameworks (MOFs) also makes it relevant for advanced material science applications.

From a commercial perspective, the global market for brominated fine chemicals is projected to grow at 5.8% CAGR (2023-2030), driven by demand in high-performance polymers and electronic materials. Manufacturers of 51528-22-4 are adopting continuous flow chemistry to improve production efficiency—a response to industry needs for process intensification and reduced energy consumption.

Analytical characterization of 2-Bromopentanedioic Acid typically involves HPLC purity testing and NMR spectroscopy, with industry standards requiring ≥98% purity for most applications. Storage recommendations emphasize protection from moisture and light to prevent degradation—a consideration frequently searched by laboratory professionals.

Emerging applications in bioconjugation chemistry have expanded the compound's relevance. Its bromine atom serves as an effective handle for click chemistry reactions, enabling the development of novel drug-delivery systems and diagnostic probes. This positions 2-Bromopentanedioic Acid as a strategic material in the booming theranostics market.

Regulatory compliance remains a key consideration for users of CAS 51528-22-4. While not classified as hazardous under major chemical inventories, proper laboratory safety protocols should always be followed. The compound's REACH registration status and SDS documentation are frequently searched topics among European chemical users.

Future research directions may explore the compound's potential in CO2 capture technologies and battery electrolytes—areas gaining traction due to global sustainability initiatives. The adaptability of 2-Bromopentanedioic Acid derivatives in these cutting-edge applications underscores its enduring value in chemical innovation.

• 584-93-0(2-Bromovaleric acid)
• 135312-82-2(2-BROMOTETRADECANOIC ACID)
• 1450-81-3(2,5-Dibromopentanoic acid)
• 142-94-9(2-Bromostearic acid)
• 18263-25-7(2-Bromopalmitic Acid)
• 616-05-7(2-Bromohexanoic acid)
• 17108-71-3(9(10)-BROMOSTEARIC ACID MIXED ISOMERS)
• 111-56-8(Dodecanoic acid,2-bromo-)
• 2624-01-3(Heptanoic acid,2-bromo-)
• 154701-76-5(Tetracosanoic acid, 2-bromo-)