• 1. Exciton manipulation in rippled transition metal dichalcogenides?
  Chen Long,Ying Dai,Jianwei Li,Hao Jin Nanoscale, 2020,12, 21124-21130
• 2. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 3. Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation
  Matthew J. Gaunt,Jinquan Yu,Jonathan B. Spencer Chem. Commun., 2001, 1844-1845
• 4. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 5. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
  Dalton Trans., 2003, 4193-4207

Tetrachloropyridin-2-amine (CAS No. 51501-52-1): A Comprehensive Overview

Tetrachloropyridin-2-amine, identified by its Chemical Abstracts Service (CAS) number 51501-52-1, is a significant compound in the realm of organic chemistry and pharmaceutical research. This heterocyclic amine derivative has garnered attention due to its unique structural properties and potential applications in various chemical syntheses. The presence of four chlorine atoms on the pyridine ring imparts distinct reactivity, making it a valuable intermediate in the development of complex molecular architectures.

The< strong>tetrachloropyridin-2-amine molecule exhibits a high degree of electrophilicity, which is primarily attributed to the electron-withdrawing nature of the chlorine substituents. This characteristic enhances its utility in nucleophilic substitution reactions, where it can serve as a precursor for synthesizing more intricate pyridine-based compounds. In recent years, advancements in synthetic methodologies have enabled researchers to explore novel derivatives of< strong>tetrachloropyridin-2-amine, expanding its scope in medicinal chemistry and material science.

One of the most compelling aspects of< strong>tetrachloropyridin-2-amine is its role in the development of bioactive molecules. The pyridine core is a common structural motif in many pharmaceuticals, owing to its ability to interact with biological targets such as enzymes and receptors. Researchers have leveraged the reactivity of< strong>tetrachloropyridin-2-amine to design and synthesize analogs with enhanced binding affinity and selectivity. For instance, studies have demonstrated its utility in creating inhibitors for various therapeutic targets, including kinases and proteases.

In the context of modern drug discovery, the< strong>tetrachloropyridin-2-amine scaffold has been employed to develop novel antiviral and anticancer agents. The chlorine atoms on the pyridine ring provide multiple sites for functionalization, allowing chemists to tailor the molecule's properties for specific biological activities. Recent publications highlight its incorporation into libraries of small molecules designed for high-throughput screening, aiming to identify potent lead compounds with therapeutic potential.

The synthesis of< strong>tetrachloropyridin-2-amine typically involves multi-step reactions that require precise control over reaction conditions. Common methodologies include chlorination of pyridine derivatives followed by amination, where protective groups are often employed to ensure regioselectivity. Advances in catalytic systems have also enabled more efficient routes to< strong>tetrachloropyridin-2-amine, reducing the need for hazardous reagents and improving overall yields.

The pharmacological profile of< strong>tetrachloropyridin-2-amine has been extensively studied in preclinical models. Its derivatives have shown promise in modulating various signaling pathways relevant to human diseases. For example, certain analogs have demonstrated inhibitory effects on inflammatory pathways, suggesting their potential as anti-inflammatory agents. Additionally, structural modifications have led to compounds with neuroprotective properties, which are being explored for treating neurodegenerative disorders.

The industrial applications of< strong>tetrachloropyridin-2-amine extend beyond pharmaceuticals into agrochemicals and specialty chemicals. Its versatility as a building block allows for the synthesis of intermediates used in crop protection agents and advanced materials. The ability to functionalize the pyridine ring at multiple positions provides chemists with a flexible platform for creating diverse molecular structures with tailored functionalities.

Recent research has also highlighted the role of< strong>tetrachloropyridin-2-amine in green chemistry initiatives. Efforts to develop sustainable synthetic routes have focused on minimizing waste and reducing energy consumption. Catalytic processes that utilize recyclable ligands or renewable feedstocks are being explored as alternatives to traditional methods. These innovations align with global efforts to promote environmentally responsible chemical manufacturing.

The future prospects for< strong>tetrachloropyridin-2-amine are promising, with ongoing investigations into its applications in nanotechnology and electronic materials. The compound's ability to form stable complexes with metal ions has opened avenues for developing new types of catalysts and luminescent materials. Furthermore, its incorporation into organic semiconductors has shown potential for use in flexible electronics and optoelectronic devices.

In conclusion, Tetrachloropyridin-2-amine (CAS No. 51501-52-1) represents a versatile and valuable compound with broad applications across multiple scientific disciplines. Its unique structural features and reactivity make it an indispensable tool for synthetic chemists and pharmaceutical researchers alike. As new methodologies continue to emerge, the potential uses for this compound are expected to expand further, driving innovation in both academic research and industrial applications.

• 116632-24-7(4,6-dichloropyridin-2-amine)
• 188577-69-7(3,4-Dichloropyridin-2-amine)
• 55933-91-0(3,4,5-Trichloropyridin-2-amine)
• 55933-94-3(2,3,5-trichloro-6-hydrazinylpyridine)
• 19942-40-6(2-Pyridinamine, 3,4,5,6-tetrachloro-N,N-dimethyl-)
• 55933-92-1(2-Pyridinamine, 3,5,6-trichloro-N-methyl-)
• 313535-01-2(3,6-Dichloropyridin-2-amine)
• 1188263-42-4(4,6-Dichloropyridin-2-amine hydrochloride)
• 725208-26-4(3,5,6-Trichloro-2,4-pyridinediamine)
• 1192814-45-1(5,6-dichloropyridin-2-amine)