Cas no 5142-23-4 (3-Methyladenine)
3-Methyladenine (3-MA) is a purine derivative widely recognized for its role as an autophagy inhibitor. It functions by blocking class III phosphatidylinositol 3-kinase (PI3K), thereby inhibiting autophagosome formation. This compound is extensively utilized in biochemical and cell biology research to study autophagy-related pathways and their implications in diseases such as cancer and neurodegeneration. 3-Methyladenine is valued for its specificity and well-characterized mechanism of action, making it a reliable tool for investigating cellular degradation processes. Its stability and solubility in aqueous solutions further enhance its practicality for experimental applications. Researchers employ 3-MA to elucidate the regulatory mechanisms of autophagy and its interplay with apoptosis.
3-Methyladenine structure
Product Name:3-Methyladenine
CAS No:5142-23-4
MF:C6H7N5
MW:149.153279542923
MDL:MFCD00010531
CID:370088
PubChem ID:253660841
Update Time:2025-06-09
3-Methyladenine Chemical and Physical Properties
Names and Identifiers
-
- 3-METHYLADENINE
- 3H-Purin-6-amine,3-methyl-
- 3-MA
- 3-Methyl-3H-purin-6-amine
- 3-Methyladenine (3-MA)
- 3-methylpurin-6-amine
- 6-?Amino-?3-?methylpurine
- 3-MA,6-Amino-3-methylpurine
- 6-Amino-3-methylpurine
- 3-Methyl-6-aminopurine
- N3-Methyladenine
- NSC 66389
- 3H-Purin-6-amine, 3-methyl-
- 3-Methyl-3H-adenine
- ADENINE, 3-METHYL-
- 3-METHYL-3H-PURIN-6-YLAMINE
- 3-Methyladenine autophagy inhibitor
- 3mea
- 4aia
- 3-methyl-Adenine
- NSC66389
- 1p7m
- 4ai5
- Autophagy Inhibitor, 3-MA
- NCIOpen2_000270
- SCHEMB
- HB2267
- 3-methyl-7H-purin-6-imine
- EINECS 225-908-6
- FT-0635560
- NSC-66389
- Bio1_000422
- 3-methyl-3H-purin-6-amine (ACD/Name 4.0)
- AC-28818
- 3-MA nucleobase
- C00913
- 3899G64TKW
- AKOS003382321
- M2518
- SCHEMBL48369
- 5-26-17-00151 (Beilstein Handbook Reference)
- FSASIHFSFGAIJM-UHFFFAOYSA-N
- HMS3656P04
- SCHEMBL254058
- UNII-3899G64TKW
- J-640198
- 3,9-dihydro-3-methyl-6H-Purin-6-imine
- 60192-57-6
- UNII-DR88TV7SNU
- DTXSID901346127
- METHYLADENINE, N(3)-
- 5142-23-4
- CHEMBL292268
- CS-5207
- 3-methyl adenine
- PD019337
- AS-19224
- BRD-K81647657-001-01-9
- s2767
- N(3)-methyladenine
- AMY11868
- W-202935
- CCG-206388
- SMR002530641
- C6H7N5
- SY026559
- AKOS006228458
- HY-19312
- Bio1_000911
- 3-Methyladenine, autophagy inhibitor
- DR88TV7SNU
- BDBM50488841
- BCP02452
- A7582
- MLS006010995
- MFCD00010531
- EX-A130
- CHEMBL4303725
- CHEBI:38635
- SW220216-1
- FT-0671432
- 3-Methyl-d3-adenine
- 3-Methyl-3H-purin-6-amine #
- NCGC00345447-02
- Purine, 3,6-dihydro-6-imino-3-methyl-
- InChI=1/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H
- SCHEMBL15764619
- 3-methyl-3H-purin-6-ylamine (ACD/Name 4.0)
- 6H-Purin-6-imine, 3,9-dihydro-3-methyl-
- Q27094948
- DB04104
- 6H-Purin-6-imine, 3,7-dihydro-3-methyl-
- NS00005696
- Bio1_001400
- DTXSID80199406
- J-800199
- BRN 0146087
- 3-Methyladenine?
- 1ST2663
- GLXC-04639
- 3-Methyladenine (3-MA; Autophagy Inhibitor)
- 3-Methyladenine, NSC-66389
- BRD-K81647657-001-05-0
- purine, 6-amino-3-methyl-
- SDCCGSBI-0634490.P005
- ZPBYVFQJHWLTFB-UHFFFAOYSA-N
- BRD-K81647657-001-04-3
- 3-MA , NSC 66389
- DB-051961
- 3-Methyladenine
-
- MDL： MFCD00010531
- Inchi： 1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3,7H,1H3,(H,8,9)
- InChI Key： ZPBYVFQJHWLTFB-UHFFFAOYSA-N
- SMILES： N1(C)C=NC(C2=C1N=CN2)=N
- BRN： 0146087
Computed Properties
- Exact Mass: 149.07000
- Monoisotopic Mass: 149.07014524g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 11
- Rotatable Bond Count: 0
- Complexity: 211
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: 3
- XLogP3: -0.6
- Topological Polar Surface Area: 68.1
Experimental Properties
- Color/Form: Uncertain
- Density: 1.60
- Melting Point: ~300?°C (dec.) (lit.)
- Boiling Point: 240.1°C at 760 mmHg
- Flash Point: 99 oC
- Refractive Index: 1.8070 (estimate)
- PSA: 69.62000
- LogP: 0.52670
- Solubility: Uncertain
3-Methyladenine Security Information
-
Symbol:
- Prompt：warning
- Signal Word：Danger
- Hazard Statement： H301
- Warning Statement： P301 + P310
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Hazard Category Code： 22
- Safety Instruction： S24/25
- RTECS：AU6520000
-
Hazardous Material Identification：
- Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
- Risk Phrases：R22
3-Methyladenine Customs Data
- HS CODE：2933990090
- Customs Data：
China Customs Code:
2933990090Overview:
2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
3-Methyladenine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| MedChemExpress | HY-19312-50mg |
3-Methyladenine |
5142-23-4 | 99.91% | 50mg |
￥550 | 2025-04-16 | |
| MedChemExpress | HY-19312-100mg |
3-Methyladenine |
5142-23-4 | 99.91% | 100mg |
￥800 | 2025-04-16 | |
| MedChemExpress | HY-19312-200mg |
3-Methyladenine |
5142-23-4 | 99.91% | 200mg |
￥1400 | 2025-04-16 | |
| MedChemExpress | HY-19312-500mg |
3-Methyladenine |
5142-23-4 | 99.91% | 500mg |
￥2800 | 2025-04-16 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M129496-1g |
3-Methyladenine |
5142-23-4 | 98% | 1g |
￥298.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M129496-25g |
3-Methyladenine |
5142-23-4 | 98% | 25g |
￥4454.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M129496-250mg |
3-Methyladenine |
5142-23-4 | 98% | 250mg |
￥190.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M129496-5g |
3-Methyladenine |
5142-23-4 | 98% | 5g |
￥1104.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M129496-50mg |
3-Methyladenine |
5142-23-4 | 98% | 50mg |
￥102.90 | 2023-09-02 | |
| HE FEI BO MEI SHENG WU KE JI YOU XIAN ZE REN GONG SI | JM9281-100mg |
3-Methyladenine |
5142-23-4 | ≥98% | 100mg |
￥1580.00元 | 2023-09-15 |
3-Methyladenine Related Literature
-
Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
-
Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
-
Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
-
Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090
-
Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
Related Categories
- Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Imidazopyrimidines 6-aminopurines
- Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Imidazopyrimidines Purines and purine derivatives 6-aminopurines
- Pharmaceutical and Biochemical Products Medical Target Class
5142-23-4 (3-Methyladenine) Related Products
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- 773784-99-9(Methanamine,N-(1,6,7-trimethyl-4(1H)-pteridinylidene)-)
- 102236-40-8(4(1H)-Pteridinimine,1,6,7-trimethyl-)
- 51584-35-1(Methanamine, N-(3,7-dihydro-3,7-dimethyl-6H-purin-6-ylidene)-)
- 10091-84-6(3-(3-methylbut-2-en-1-yl)-3H-purin-6-amine)
- 10211-84-4(3H-Purin-6-amine,3-(phenylmethyl)-, hydrochloride (1:1))
- 175600-96-1(3H-Purine-3,6-diamine)
- 89018-79-1(6H-Purin-6-imine, 3,7-dihydro-3,7-dimethyl-, monoperchlorate)
- 7280-81-1(3-Benzyladenine)
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