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Formamide-13C: A Comprehensive Overview

Formamide, also known as formamide-13C, is a chemical compound with the CAS number 51284-91-4. This compound is a stable isotope-labeled version of formamide, where the carbon atom is replaced with the carbon-13 isotope. Formamide itself is a simple amide with the molecular formula CH?NO, and its 13C-labeled counterpart, formamide-13C, has gained significant attention in various scientific fields due to its unique properties and applications.

The synthesis of formamide-13C involves the use of carbon-13 enriched starting materials, which ensures that the carbon atom in the amide group is exclusively the heavier isotope. This process is highly controlled to maintain the purity and stability of the compound. The production of formamide-13C has been optimized over the years, with advancements in isotopic labeling techniques enabling higher yields and better quality control.

One of the most notable applications of formamide-13C is in nuclear magnetic resonance (NMR) spectroscopy. Due to its distinct chemical shift caused by the presence of carbon-13, formamide-13C serves as an excellent reference compound for calibrating NMR instruments. This property has made it indispensable in analytical chemistry, where precise measurements are critical for determining molecular structures and compositions.

In recent years, formamide-13C has also found applications in metabolic studies and stable isotope probing (SIP). Researchers utilize this compound to trace metabolic pathways in biological systems, providing insights into enzyme kinetics and substrate utilization. For instance, studies have employed formamide-13C to investigate carbon fluxes in microbial communities, contributing to our understanding of carbon cycling in ecosystems.

The physical properties of formamide-13C are similar to those of regular formamide, with a slight increase in molecular weight due to the substitution of carbon-12 with carbon-13. It remains a colorless liquid with a high boiling point, making it suitable for various chemical reactions and analytical techniques. Its thermal stability ensures that it can be used under a wide range of experimental conditions without degradation.

From a chemical standpoint, formamide-13C exhibits reactivity comparable to its natural counterpart. It can participate in nucleophilic acyl substitution reactions, making it a valuable reagent in organic synthesis. Recent advancements in catalytic chemistry have explored the use of formamide-13C as a precursor for synthesizing complex molecules, leveraging its unique isotopic signature for tracking reaction mechanisms.

In terms of safety and handling, formamide-13C shares the same safety profile as regular formamide. It is considered non-toxic but should be handled with care due to its ability to absorb moisture from the air. Proper storage in sealed containers is recommended to maintain its purity and prevent contamination.

The demand for formamide-13C has grown significantly with advancements in analytical techniques and metabolic research. Its role as an isotopic tracer has solidified its position as an essential tool in modern chemistry and biology. As research continues to uncover new applications for this compound, its importance in scientific studies will only continue to rise.

• 35645-04-6(Formamide-N,N-d2)
• 77287-35-5(Methanimidic acid, (E)-)
• 1449-77-0(Formamide-15N)
• 104809-61-2(Formamide-14C (9CI))
• 56827-75-9(Formamide, monohydrate)
• 35692-88-7(Formamide-1-d1)
• 43380-64-9(Formamide-d3)
• 2858-51-7(Methyl, aminooxo- (9CI))
• 75-12-7(Formamide)
• 285977-74-4(Formamide-13C, 15N)