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  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
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  Chem. Commun., 1998, 1501-1502
• 3. Distinct impact of glycation towards the aggregation and toxicity of murine and human amyloid-β?
  Eunju Nam,Jiyeon Han,Sunhee Choi,Mi Hee Lim Chem. Commun., 2021,57, 7637-7640
• 4. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Phenol ethers
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers

[4-(Benzyloxy)phenoxy]acetonitrile: A Comprehensive Overview

The compound [4-(Benzyloxy)phenoxy]acetonitrile is a highly specialized chemical entity that has garnered significant attention in the fields of biopharmaceuticals, chemical synthesis, and materials science. Its unique structure, combining a benzyloxy group with a phenoxy moiety linked to an acetonitrile functional group, makes it a versatile building block for various applications. This article delves into the properties, synthesis, and potential uses of this compound, leveraging insights from recent research.

Firstly, understanding the chemical structure of [4-(Benzyloxy)phenoxy]acetonitrile is crucial. The molecule consists of a phenoxy ring substituted at the para position with a benzyloxy group and connected via an acetonitrile chain. This arrangement imparts the compound with both aromatic and nitrile functionalities, which are highly valued in drug discovery and polymer chemistry.

Recent studies have highlighted the potential of benzyloxyphenoxyacetonitrile derivatives in anticancer therapy. The acetonitrile group, known for its electron-withdrawing properties, can enhance the pharmacokinetics of drugs by improving solubility and bioavailability. Furthermore, the benzyloxy moiety has been shown to exhibit antioxidant activity, which is beneficial in mitigating oxidative stress associated with cancer progression.

In terms of synthesis, [4-(Benzyloxy)phenoxy]acetonitrile can be prepared via a multi-step reaction sequence. Starting from benzaldehyde, the benzyloxy group is introduced through a Williamson ether synthesis. Subsequent coupling with a phenoxy group and acylation leads to the desired product. This synthetic route is efficient and scalable, making it suitable for large-scale production.

Another area of interest is the application in biotechnology. The compound's nitrile functionality can be functionalized to form hydrogels or other biomaterials with tunable properties. For instance, studies have demonstrated its use as a precursor for drug delivery systems, where the benzyloxy group serves as a site for further functionalization.

Moreover, the compound's photophysical properties have been explored in the context of optoelectronic materials. The conjugation between the aromatic rings and the nitrile group enables applications in light-emitting diodes (LEDs) and organic photovoltaics. Recent advancements in this field have further enhanced the compound's utility, making it a valuable component in next-generation electronic devices.

Finally, the toxicological profile of [4-(Benzyloxy)phenoxy]acetonitrile is an important consideration for its safe use. While preliminary studies indicate low toxicity at recommended doses, further research is ongoing to fully characterize its behavior in biological systems.

• 19962-28-8(Benzene,1-methoxy-4-(phenoxymethyl)-)
• 50635-22-8(m-Tolyloxyacetonitrile)
• 33901-44-9(4-Methylphenoxyacetonitrile)
• 52805-36-4(4-(Benzyloxy)benzonitrile)
• 431946-37-1(Benzonitrile, 4-(phenylmethoxy)-)
• 10403-79-9(Benzene,1,4-bis(phenoxymethyl)-)
• 6630-18-8(4-Benzyloxyanisole)
• 77151-89-4(Phenol, 4-[(4-methoxyphenyl)methoxy]-)
• 34904-99-9(3-(phenoxymethyl)phenylmethanol)
• 55846-07-6(Phenol,4-(phenoxymethyl)-)