• 1. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 2. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
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  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
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  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzenes

N-Isopropyl-3-nitrobenzamide (CAS No. 50445-53-9): Properties, Applications, and Market Insights

N-Isopropyl-3-nitrobenzamide (CAS No. 50445-53-9) is a specialized organic compound with significant relevance in pharmaceutical and agrochemical research. This nitrobenzamide derivative features an isopropyl group attached to the amide nitrogen, offering unique chemical properties that make it valuable for synthetic applications. The compound's molecular formula is C₁₀H₁₂N₂O₃, with a molecular weight of 208.22 g/mol.

The growing interest in N-Isopropyl-3-nitrobenzamide uses stems from its role as a key intermediate in drug discovery. Researchers are particularly focused on its potential in developing novel enzyme inhibitors and bioactive molecules. Recent studies highlight its importance in creating compounds with potential therapeutic effects, aligning with current trends in precision medicine and targeted drug delivery systems.

From a chemical perspective, 3-nitro-N-isopropylbenzamide demonstrates moderate solubility in organic solvents like ethanol and dimethyl sulfoxide (DMSO), while being less soluble in water. This property profile makes it particularly useful in organic synthesis workflows. The compound's stability under various conditions has been documented in recent pharmaceutical chemistry journals, with particular attention to its behavior in different pH environments.

The synthesis of N-Isopropyl-3-nitrobenzamide typically involves the reaction of 3-nitrobenzoyl chloride with isopropylamine. This process has been optimized in recent years to improve yield and purity, addressing common questions about how to synthesize N-Isopropyl-3-nitrobenzamide efficiently. Modern synthetic approaches emphasize green chemistry principles, reducing waste and improving sustainability - a key concern in current pharmaceutical manufacturing trends.

Analytical characterization of 50445-53-9 compound typically employs techniques such as HPLC, NMR spectroscopy, and mass spectrometry. These methods verify the compound's purity and structural integrity, which are critical factors for research applications. Recent advancements in analytical technology have enabled more precise quantification of impurities, meeting the stringent requirements of pharmaceutical quality control standards.

In the current market, demand for N-Isopropyl-3-nitrobenzamide suppliers has shown steady growth, particularly from contract research organizations and academic institutions. The compound's price varies depending on purity grade and quantity, with research-grade material typically ranging between $50-$200 per gram. Market analysts note increased interest from Asia-Pacific regions, reflecting broader trends in pharmaceutical outsourcing and research collaboration.

Storage and handling of N-Isopropyl-3-nitrobenzamide powder require standard laboratory precautions. The compound should be kept in tightly sealed containers at room temperature, protected from light and moisture. These storage conditions align with general best practices for research chemical preservation and ensure material stability over extended periods.

Future research directions for CAS 50445-53-9 include exploring its potential in novel drug formulations and investigating its biochemical interactions more comprehensively. The scientific community continues to examine its structure-activity relationships, particularly how modifications to the isopropyl or nitro groups might enhance desired properties. These investigations contribute to the broader field of medicinal chemistry innovation.

For researchers sourcing this material, it's important to verify certificates of analysis and ensure suppliers comply with current Good Manufacturing Practices. The compound's availability from multiple global suppliers has improved in recent years, though quality variations between sources remain a consideration for sensitive applications.

The environmental profile of N-Isopropyl-3-nitrobenzamide has gained attention as part of the pharmaceutical industry's focus on green chemistry metrics. Recent lifecycle assessments examine its biodegradation pathways and potential ecological impacts, addressing growing concerns about sustainable chemical development.

Patent literature reveals ongoing interest in 3-nitro-N-isopropylbenzamide applications, with several recent filings describing its use in novel synthetic routes or as a precursor for more complex molecules. This intellectual property activity indicates the compound's continuing relevance in innovative chemical research.

Academic interest in 50445-53-9 research appears in numerous recent publications, particularly in journals focusing on synthetic organic chemistry and medicinal chemistry. These studies often explore the compound's reactivity patterns or its incorporation into larger molecular architectures, contributing valuable knowledge to the chemical research community.

As the pharmaceutical industry continues to evolve, N-Isopropyl-3-nitrobenzamide maintains its position as a versatile building block in drug discovery. Its balanced properties and well-characterized behavior make it a reliable choice for researchers developing next-generation therapeutic agents, particularly in areas addressing emerging health challenges.

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