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• 2. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
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• 3. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
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• 4. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Phenylpyrazoles
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles Phenylpyrazoles

Comprehensive Overview of Ethyl 1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate (CAS No. 503614-56-0)

Ethyl 1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate (CAS 503614-56-0) is a specialized heterocyclic compound with significant potential in pharmaceutical and agrochemical research. This molecule features a unique pyrazolo[3,4-c]pyridine core, a scaffold increasingly recognized for its bioactivity in drug discovery. Researchers are particularly interested in its ethyl carboxylate and 4-methoxyphenyl substituents, which contribute to its solubility and binding affinity in biological systems.

The compound's structural complexity aligns with current trends in fragment-based drug design and small-molecule therapeutics, addressing growing demand for treatments targeting neurological and metabolic disorders. Recent literature highlights derivatives of pyrazolo[3,4-c]pyridine as potential kinase inhibitors, making CAS 503614-56-0 particularly relevant to cancer research. Its 7-oxo-tetrahydro moiety also suggests possible applications in developing anti-inflammatory agents, a hot topic in post-pandemic healthcare innovation.

From a synthetic chemistry perspective, Ethyl 1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate exemplifies modern green chemistry principles. The methoxy group enhances stability while the ethyl ester functionality allows for straightforward derivatization – key considerations for sustainable pharmaceutical manufacturing. Analytical studies using HPLC-MS and NMR confirm its high purity (>98%), meeting stringent requirements for preclinical studies.

The compound's physicochemical properties – including logP values between 2.1-2.5 and water solubility >50 mg/mL at pH 7 – make it suitable for drug formulation research. These characteristics address frequent queries from researchers about bioavailability optimization and structure-activity relationships. Computational modeling suggests the pyrazolo-pyridine system may interact with GABA receptors, connecting to popular searches about neuroactive compounds and CNS drug development.

In material science applications, the conjugated system of CAS 503614-56-0 shows promise for organic electronics, responding to growing interest in bio-based semiconductors. The methoxyphenyl group provides electron-donating properties that could enhance charge transport in thin-film devices. This dual pharmaceutical-material potential makes the compound a valuable subject for interdisciplinary research, a major focus area in contemporary scientific funding.

Safety evaluations indicate the compound requires standard laboratory precautions, with no exceptional hazards reported. Proper handling of the ethyl carboxylate derivative follows conventional organic chemistry protocols. Storage recommendations (-20°C under nitrogen) align with best practices for heterocyclic compound preservation, a common concern among purchasing researchers.

The synthesis of Ethyl 1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate typically involves multicomponent reactions – a technique gaining traction due to its atom economy. Recent patents describe improved yields (>75%) through microwave-assisted synthesis, addressing industry demands for cost-effective production methods. These advances position 503614-56-0 as a viable candidate for scale-up in contract research organizations.

Emerging studies suggest the compound's framework could be adapted for proteolysis-targeting chimeras (PROTACs), connecting to cutting-edge targeted protein degradation research. The pyrazolo[3,4-c]pyridine core may serve as a versatile linker in these bifunctional molecules, answering frequent queries about E3 ligase binders in drug discovery forums.

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