Cas no 500287-94-5 ((1Z)-Rilpivirine)
(1Z)-Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1 infection. Its key advantage lies in its high selectivity and potency against HIV-1 reverse transcriptase, effectively suppressing viral replication. The (1Z)-isomer configuration contributes to its improved binding affinity and metabolic stability compared to other forms. It exhibits a favorable pharmacokinetic profile, including prolonged half-life and reduced drug-drug interactions, making it suitable for once-daily dosing. Additionally, (1Z)-Rilpivirine demonstrates a lower risk of adverse effects, such as neuropsychiatric or lipid abnormalities, compared to earlier NNRTIs. Its compatibility with fixed-dose combinations further enhances its utility in antiretroviral therapy regimens.
(1Z)-Rilpivirine structure
Product Name:(1Z)-Rilpivirine
CAS No:500287-94-5
MF:C22H18N6
MW:366.418523311615
CID:1544855
PubChem ID:5270790
Update Time:2025-10-29
(1Z)-Rilpivirine Chemical and Physical Properties
Names and Identifiers
-
- Benzonitrile,4-[[4-[[4-[(1Z)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]-
- (1Z)-Rilpivirine
- R289932
- (1Z)-Rilpivirine; 4-[[4-[[4-[(1Z)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile; Rilpivirine Z-Isomer
- Rilpivirine, (Z)-
- 500287-94-5
- UNII-11O8GSL573
- Rilpivirine Z-Isomer HCl
- R-289932
- 11O8GSL573
- 4-[[4-[4-[(Z)-2-cyanoethenyl]-2,6-dimethylanilino]pyrimidin-2-yl]amino]benzonitrile
- Rilpivirine metabolite 43
- TMC278(Z-ISOMER)
- Rilpivirine cis isomer
- SCHEMBL384695
- 4-[[4-[4-[(Z)-2-cyanovinyl]-2,6-dimethyl-anilino]pyrimidin-2-yl]amino]benzonitrile
- Rilpivirine cis-isomer
- Benzonitrile, 4-((4-((4-((1Z)-2-cyanoethenyl)-2,6-dimethylphenyl)amino)-2-pyrimidinyl)amino)-
- 4-{4-[4-((Z)-2-Cyano-vinyl)-2,6-dimethyl-phenylamino]-pyrimidin-2-ylamino}-benzonitrile
- 4-[[4-[[4-[(1Z)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]-benzonitrile
- CHEMBL177437
-
- Inchi： 1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3-
- InChI Key： YIBOMRUWOWDFLG-ARJAWSKDSA-N
- SMILES： N(C1C=CN=C(NC2C=CC(C#N)=CC=2)N=1)C1C(C)=CC(/C=C\C#N)=CC=1C
Computed Properties
- Exact Mass: 366.15954
- Monoisotopic Mass: 366.15929460g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 6
- Heavy Atom Count: 28
- Rotatable Bond Count: 5
- Complexity: 607
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 1
- Undefined Bond Stereocenter Count: 0
- XLogP3: 4.5
- Topological Polar Surface Area: 97.4?2
Experimental Properties
- PSA: 97.42
(1Z)-Rilpivirine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | R509805-1mg |
(1Z)-Rilpivirine |
500287-94-5 | 1mg |
$253.00 | 2023-05-17 | ||
| TRC | R509805-2.5mg |
(1Z)-Rilpivirine |
500287-94-5 | 2.5mg |
$540.00 | 2023-05-17 | ||
| TRC | R509805-5mg |
(1Z)-Rilpivirine |
500287-94-5 | 5mg |
$1016.00 | 2023-05-17 | ||
| TRC | R509805-10mg |
(1Z)-Rilpivirine |
500287-94-5 | 10mg |
$1918.00 | 2023-05-17 | ||
| TRC | R509805-50mg |
(1Z)-Rilpivirine |
500287-94-5 | 50mg |
$ 9200.00 | 2023-09-06 |
(1Z)-Rilpivirine Related Literature
-
Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
-
Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
-
Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
-
Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
-
Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
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