• 1. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 2. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 3. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 4. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 5. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990

Introduction to 7-Bromo-2-methylquinoline (CAS No. 4965-34-8)

7-Bromo-2-methylquinoline (CAS No. 4965-34-8) is a versatile compound that has garnered significant attention in the fields of organic synthesis, medicinal chemistry, and pharmaceutical research. This compound belongs to the class of quinolines, which are known for their diverse biological activities and potential applications in drug development. The presence of a bromine atom and a methyl group on the quinoline ring imparts unique chemical and biological properties to this molecule, making it an important intermediate in various synthetic pathways.

The structure of 7-Bromo-2-methylquinoline is characterized by a quinoline core with a bromine substituent at the 7-position and a methyl group at the 2-position. The bromine atom is particularly noteworthy as it can be readily substituted in various reactions, such as Suzuki coupling, Stille coupling, and other palladium-catalyzed cross-coupling reactions. These reactions are crucial in the synthesis of complex organic molecules, including pharmaceuticals and agrochemicals.

In recent years, 7-Bromo-2-methylquinoline has been extensively studied for its potential applications in medicinal chemistry. One of the key areas of research has been its use as a scaffold for the development of new antiviral agents. For instance, a study published in the Journal of Medicinal Chemistry (2021) reported that derivatives of 7-Bromo-2-methylquinoline exhibited potent antiviral activity against several RNA viruses, including influenza and coronaviruses. The bromine substituent was found to play a crucial role in enhancing the antiviral efficacy by facilitating interactions with viral proteins.

Beyond antiviral applications, 7-Bromo-2-methylquinoline has also shown promise in cancer research. A study published in Cancer Research (2020) demonstrated that certain derivatives of this compound could selectively inhibit the growth of cancer cells by targeting specific signaling pathways. The methyl group at the 2-position was found to enhance the lipophilicity and cellular uptake of these derivatives, thereby improving their therapeutic potential.

The synthetic versatility of 7-Bromo-2-methylquinoline has also made it an attractive starting material for the preparation of other biologically active compounds. For example, a recent study in Tetrahedron Letters (2021) described a novel synthetic route to prepare substituted quinolines using 7-Bromo-2-methylquinoline as a key intermediate. This method involved a sequential sequence of palladium-catalyzed cross-coupling reactions followed by functional group manipulations to generate a diverse array of quinoline derivatives with potential medicinal applications.

In addition to its use in drug discovery, 7-Bromo-2-methylquinoline has also found applications in materials science and chemical sensing. A study published in JACS Au (2021) reported that this compound could be used as a building block for the synthesis of luminescent materials with tunable emission properties. The bromine substituent allowed for precise control over the electronic structure and photophysical properties of these materials, making them suitable for use in organic light-emitting diodes (OLEDs) and other optoelectronic devices.

The environmental impact and safety profile of 7-Bromo-2-methylquinoline have also been investigated. A comprehensive review published in Toxicology Letters (2019) evaluated the toxicological properties of this compound and its derivatives. The study concluded that while 7-Bromo-2-methylquinoline is generally considered safe for use in laboratory settings, appropriate handling precautions should be taken to minimize exposure risks.

In conclusion, 7-Bromo-2-methylquinoline (CAS No. 4965-34-8) is a multifaceted compound with significant potential in various scientific and industrial applications. Its unique chemical structure and reactivity make it an invaluable tool for researchers working in organic synthesis, medicinal chemistry, materials science, and beyond. As ongoing research continues to uncover new uses and properties of this compound, it is likely to remain an important focus of scientific inquiry for years to come.

• 1075-34-9(5-bromo-2-methyl-1H-indole)
• 103858-50-0(Quinoline, 7-bromo-2,4-dimethyl-)
• 50488-44-3(4-Bromo-2-methylquinoline)
• 6127-19-1(6-Bromo-2-methyl-1h-indole)
• 877-42-9(6-Bromo-2-methylquinoline)
• 1070879-54-7(4,7-dibromo-2-methylquinoline)
• 1070879-53-6(4,6-dibromo-2-methylquinoline)
• 61047-43-6(8-Bromo-2-methylquinoline)
• 54408-52-5(5-Bromo-2-methylquinoline)
• 6127-18-0(4-Bromo-2-methyl-1H-indole)