• 1. Novel base-induced reactions of substituted (1,2-benzisoxazol-3-yl)acetates
  Shōzō Ueda,Shunsuke Naruto,Toyokichi Yoshida,Tadahiro Sawayama,Hitoshi Uno J. Chem. Soc. Perkin Trans. 1 1988 1013
• 2. Novel base-induced ring transformation of 1,2-benzisoxazole-3-acetic acid esters into 2H-azirines or benzofurans
  Shōzō Ueda,Shunsuke Naruto,Toyokichi Yoshida,Tadahiro Sawayama,Hitoshi Uno J. Chem. Soc. Chem. Commun. 1985 218
• 3. Subject index, 1985
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Comprehensive Guide to 2-(1,2-benzoxazol-3-yl)acetic acid (CAS No. 4865-84-3): Properties, Applications, and Market Insights

2-(1,2-benzoxazol-3-yl)acetic acid (CAS No. 4865-84-3) is a specialized organic compound with significant relevance in pharmaceutical and agrochemical research. This heterocyclic derivative, featuring a benzoxazole core linked to an acetic acid moiety, has garnered attention for its versatile applications in drug discovery and material science. Researchers frequently search for "2-(1,2-benzoxazol-3-yl)acetic acid synthesis" or "benzoxazole derivatives applications," reflecting its growing importance in modern chemistry.

The molecular structure of 2-(1,2-benzoxazol-3-yl)acetic acid combines aromatic character with carboxylic acid functionality, making it a valuable intermediate. With a molecular weight of 191.17 g/mol, this white to off-white crystalline powder exhibits moderate solubility in polar organic solvents. Recent studies highlight its potential as a building block for "pharmaceutical intermediates" and "biologically active compounds," particularly in developing novel anti-inflammatory and antimicrobial agents.

In pharmaceutical applications, 2-(1,2-benzoxazol-3-yl)acetic acid serves as a key precursor for various drug candidates. The "benzoxazole acetic acid derivatives" class has shown promise in targeting specific enzymes and receptors, with researchers investigating their potential in treating metabolic disorders. The compound's structural features enable diverse chemical modifications, answering frequent queries about "modification strategies for benzoxazole compounds" in medicinal chemistry.

The agrochemical sector utilizes 2-(1,2-benzoxazol-3-yl)acetic acid in developing novel plant protection agents. Its heterocyclic framework contributes to the design of environmentally friendly pesticides, addressing current concerns about "green chemistry in agriculture." Industry reports indicate growing demand for "sustainable crop protection chemicals," where this compound plays a strategic role in formulation development.

Material science applications of 2-(1,2-benzoxazol-3-yl)acetic acid include its use in organic electronics and specialty polymers. The compound's conjugated system and functional groups make it suitable for creating "organic semiconductor materials" and "photovoltaic components." These applications align with trending searches for "organic electronic materials 2024" and "next-generation display technologies."

Quality specifications for 2-(1,2-benzoxazol-3-yl)acetic acid typically require ≥98% purity, with HPLC analysis confirming composition. Proper storage conditions (2-8°C in airtight containers) ensure stability, addressing common questions about "handling benzoxazole derivatives." Analytical techniques like NMR, MS, and IR spectroscopy provide comprehensive characterization, crucial for researchers investigating "structural confirmation of heterocyclic acids."

The global market for 2-(1,2-benzoxazol-3-yl)acetic acid reflects increasing demand from Asia-Pacific research centers and European pharmaceutical companies. Market analysts note particular interest in "custom synthesis of benzoxazole compounds" and "bulk pharmaceutical intermediates." Current pricing trends show stability, with supply chains adapting to meet growing requirements from both academic and industrial sectors.

Environmental and safety considerations for 2-(1,2-benzoxazol-3-yl)acetic acid follow standard laboratory protocols. While not classified as hazardous under normal conditions, proper PPE (lab coat, gloves, eye protection) is recommended during handling. These precautions respond to frequent queries about "safety measures for handling organic acids" in research settings.

Future research directions for 2-(1,2-benzoxazol-3-yl)acetic acid include exploration of its coordination chemistry and potential in metal-organic frameworks (MOFs). The scientific community shows growing interest in "benzoxazole-based ligands" and "functional materials design," positioning this compound as a valuable tool for advanced material development. Recent patent filings indicate expanding intellectual property surrounding its derivatives.

For researchers seeking 2-(1,2-benzoxazol-3-yl)acetic acid, multiple specialty chemical suppliers offer the compound in various quantities. Technical specifications typically include detailed certificates of analysis, addressing the need for "high-purity research chemicals." Current literature references provide additional synthesis protocols and application studies, supporting the compound's role in cutting-edge chemical research.

• 50471-23-3(1,2-Benzisoxazole-3-acetaldehyde(9CI))
• 57148-90-0(2-BenzoDisoxazol-3-ylethanol)
• 34173-07-4(Methyl 2-(6-Hydroxy-1,2-benzisoxazol-3-yl)acetate)
• 34172-98-0(2-(5-methoxybenzodisoxazol-3-yl)acetic acid)
• 34200-00-5(2-(6-methoxybenzo[d]isoxazol-3-yl)acetic acid)
• 59899-89-7(Methyl 2-(1,2-benzisoxazol-3-yl)acetate)
• 34173-03-0(2-(5-hydroxybenzodisoxazol-3-yl)acetic acid)
• 540750-32-1(6-bromo-1,2-Benzisoxazole-3-acetic acid)
• 34173-06-3(2-(6-Hydroxy-1,2-benzisoxazol-3-yl)acetic Acid)
• 70154-01-7(2-(5-methyl-1,2-benzoxazol-3-yl)acetic acid)