Cas no 486437-59-6 (1-4-(4-methylpiperidin-1-yl)phenylmethanamine)

1-4-(4-Methylpiperidin-1-yl)phenylmethanamine is a versatile organic compound featuring a phenylmethanamine core substituted with a 4-methylpiperidin-1-yl group at the para position. This structure imparts unique physicochemical properties, making it valuable in pharmaceutical and agrochemical research. The presence of the methylpiperidine moiety enhances lipophilicity and bioavailability, while the primary amine functionality allows for further derivatization, enabling its use as a key intermediate in drug synthesis. Its well-defined molecular architecture ensures consistent reactivity, facilitating applications in the development of bioactive molecules. The compound is typically supplied in high purity, ensuring reliability in experimental and industrial processes. Proper handling and storage are recommended to maintain stability.
1-4-(4-methylpiperidin-1-yl)phenylmethanamine structure
486437-59-6 structure
Product Name:1-4-(4-methylpiperidin-1-yl)phenylmethanamine
CAS No:486437-59-6
MF:C13H20N2
MW:204.311303138733
MDL:MFCD04971042
CID:1071780
PubChem ID:17608930
Update Time:2025-06-23

1-4-(4-methylpiperidin-1-yl)phenylmethanamine Chemical and Physical Properties

Names and Identifiers

    • 1-[4-(4-Methylpiperidin-1-yl)phenyl]methanamine
    • [4-(4-methylpiperidyl)phenyl]methylamine
    • 4-(4-methyl-1-piperidinyl)benzylamine
    • 4-(4-methylpiperidino)benzylamine
    • 4-(4-methylpiperidino)-benzylamine
    • AC1Q2R89
    • AGN-PC-01KY2W
    • CTK7E4525
    • SBB022482
    • SureCN4027191
    • EN300-72636
    • AKOS000218415
    • STK346730
    • [4-(4-methylpiperidin-1-yl)phenyl]methanamine
    • Z234897891
    • 486437-59-6
    • 4-(4-Methylpiperidinyl)benzylamine
    • DTXSID50589850
    • ALBB-007073
    • PTNLGUVQBDMODF-UHFFFAOYSA-N
    • MFCD04971042
    • CS-0217276
    • SCHEMBL4027191
    • FS-3301
    • (4-(4-Methylpiperidin-1-yl)phenyl)methanamine
    • DB-087225
    • 1-4-(4-methylpiperidin-1-yl)phenylmethanamine
    • MDL： MFCD04971042
    • Inchi： 1S/C13H20N2/c1-11-6-8-15(9-7-11)13-4-2-12(10-14)3-5-13/h2-5,11H,6-10,14H2,1H3
    • InChI Key： PTNLGUVQBDMODF-UHFFFAOYSA-N
    • SMILES： N1(C2C=CC(CN)=CC=2)CCC(C)CC1

Computed Properties

  • Exact Mass: 204.1628
  • Monoisotopic Mass: 204.162648646g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 15
  • Rotatable Bond Count: 2
  • Complexity: 177
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.2
  • Topological Polar Surface Area: 29.3?2

Experimental Properties

  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 348.3±25.0 °C at 760 mmHg
  • Flash Point: 146.9±18.3 °C
  • PSA: 29.26
  • Vapor Pressure: 0.0±0.8 mmHg at 25°C

1-4-(4-methylpiperidin-1-yl)phenylmethanamine Security Information

1-4-(4-methylpiperidin-1-yl)phenylmethanamine Pricemore >>

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1-4-(4-methylpiperidin-1-yl)phenylmethanamine Related Literature

Additional information on 1-4-(4-methylpiperidin-1-yl)phenylmethanamine

1-4-(4-Methylpiperidin-1-yl)phenylmethanamine: A Comprehensive Overview

1-4-(4-Methylpiperidin-1-yl)phenylmethanamine (CAS No: 486437-59-6) is a compound of significant interest in the field of organic chemistry and pharmacology. This molecule, characterized by its unique structure, has garnered attention due to its potential applications in drug discovery and development. The compound consists of a piperidine ring, which is a six-membered cyclic amine, substituted with a methyl group at the 4-position and connected to a phenylmethanamine group. This structural arrangement imparts distinctive chemical properties and biological activities.

Recent advancements in chemical synthesis have enabled the efficient production of 1-4-(4-methylpiperidin-1-yl)phenylmethanamine. Researchers have explored various synthetic pathways, including nucleophilic aromatic substitution and coupling reactions, to optimize the synthesis process. These methods not only enhance the yield but also ensure the purity of the compound, which is crucial for its intended applications.

The biological activity of 1-4-(4-methylpiperidin-1-yl)phenylmethanamine has been extensively studied in recent years. Preclinical studies have demonstrated its potential as a modulator of certain cellular pathways, making it a promising candidate for therapeutic interventions. For instance, investigations into its interaction with G-protein coupled receptors (GPCRs) have revealed its ability to modulate receptor activity, which could be harnessed for treating conditions such as neurodegenerative diseases or inflammatory disorders.

Another area of interest lies in the compound's role as a building block for more complex molecules. Its versatility in forming bonds with other functional groups makes it an invaluable intermediate in organic synthesis. For example, researchers have utilized 1-4-(4-methylpiperidin-1-yl)phenylmethanamine as a starting material for constructing bioactive molecules with enhanced pharmacokinetic profiles.

The pharmacokinetic properties of 1-4-(4-methylpiperidin-1-yl)phenylmethanamine have also been evaluated in preclinical models. Studies indicate that the compound exhibits favorable absorption and distribution characteristics, which are essential for its potential use as an orally administered drug. Furthermore, its metabolic stability has been assessed, providing insights into its suitability for long-term therapeutic applications.

In terms of safety and toxicity profiles, preliminary assessments suggest that 1-4-(4-methylpiperidin-1-yl)phenylmethanamine demonstrates low toxicity at therapeutic concentrations. However, further studies are required to fully characterize its safety profile and establish appropriate dosing regimens for clinical use.

The synthesis and characterization of 1-4-(4-methylpiperidin-1-y l)phenylmethanamine have been documented in several peer-reviewed journals, highlighting its importance in contemporary chemical research. Its structural uniqueness and functional versatility position it as a valuable asset in both academic and industrial settings.

In conclusion, 1-4-(4-methyl piperidin -1 - yl ) phen ylmeth an amine (CAS No: 486 37 -59 -6 ) represents a significant advancement in organic chemistry. With its diverse applications ranging from drug discovery to chemical synthesis, this compound continues to be a focal point for researchers worldwide. As ongoing studies unravel its full potential, it is poised to make substantial contributions to the field of medicinal chemistry.

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