Cas no 484-20-8 (Bergapten)
Bergapten Chemical and Physical Properties
Names and Identifiers
-
- 4-Methoxy-7H-furo[3,2-g]chromen-7-one
- (2-g)(1)benzopyran-7-one,4-methoxy-7h-furo
- 4-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one
- 4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one
- 4-Methoxy-furo[3,2-g]chromen-7-one
- 5-Methoxy-6,7-furanocoumarin
- 6-Hydroxy-4-methoxy-5-benzofuranacrylic acid, gamma-lactone
- 4-METHOXYFURO[3,2-G]BENZOPYRAN-7-ONE
- 5-Methoxypsoralen
- Bergapten
- BERGAPTEN(SH) PrintBack
- 4-Methoxyfuro[3,2-g]benzopyrane-7-one,5-Methoxypsoralen,Bergapten
- 4-MOP
- 5-MOP
- Bergaptan
- Geralen
- Methyl red
- Psoraderm
- Heraclin
- Majudin
- [ "" ]
- bergaptene
- 5-Methoxy psoralen
- O-Methylbergaptol
- 5-Methoxyfuranocoumarin
- Pentaderm
- 7H-Furo[3,2-g][1]benzopyran-7-one, 4-methoxy-
- 5-methoxypsoralene
- 4-methoxyfuro[3,2-g]chromen-7-one
- Bergaptene (DCF)
- 5-Methoxypsoralen with ultr
- 5-METHOXYPSORALEN (MART.)
- Spectrum_000794
- SPECTRUM300546
- MLS002454380
- BRD-K12968785-001-06-7
- A827532
- KBioGR_002055
- 5-Methoxypsoralen (obsol.)
- CCG-39946
- NSC-755877
- BCP30865
- InChI=1/C12H8O4/c1-14-12-7-2-3-11(13)16-10(7)6-9-8(12)4-5-15-9/h2-6H,1H
- 5-19-06-00004 (Beilstein Handbook Reference)
- NCGC00017357-03
- AC-34208
- 4-METHOXYFURO(3,2-G)CHROMEN-7-ONE
- SPBio_000547
- IDI1_000529
- 5-methoxyfurano[3,2-g]chromen-2-one
- HMS501K11
- 5-Methoxypsoralen, 99%
- NCI60_042121
- NCGC00091582-03
- 4-Methoxyfuro[3,2-g]benzopyrane-7-one
- Pharmakon1600-00300546
- 5-Methoxypsoralen;Heraclin
- NSC 95437
- 7H-Furo(3,2-g)(1)benzopyran-7-one, 4-methoxy-
- CHEBI:18293
- SBI-0051583.P002
- DTXCID305560
- BRD-K12968785-001-11-7
- Spectrum4_001478
- 6-Hydroxy-4-methoxy-5-benzofuranacrylic acid, .gamma.-lactone
- 5-methoxy-2H-furo[3,2-g]chromen-2-one
- BSPBio_002325
- AC-20189
- KBio1_000529
- HMS3652F19
- CHEMBL24171
- Spectrum2_000534
- TNP00299
- SR-05000002173-5
- CAS-484-20-8
- BERGAPTEN [MI]
- Oprea1_562364
- BRD-K12968785-001-03-4
- NSC95437
- 4-methoxy-7H-furo(3,2-g)chromen-7-one
- HSDB 3466
- MLS002207272
- HMS1923G13
- 5-METHOXYPSORALEN [WHO-DD]
- Q-100536
- 5-METHOXYPSORALEN (IARC)
- NCGC00091582-02
- NCGC00017357-08
- NCGC00017357-05
- 5-methoxy-psoralen
- Tox21_202357
- GTPL12431
- NSC755877
- Spectrum5_000155
- Spectrum3_000663
- bmse000758
- KBio3_001545
- 5-METHOXYPSORALEN [IARC]
- 4-Methoxy-7H-furo[3,2-g]chromen-7-one #
- Q414779
- 484-20-8
- s4239
- SR-05000002173
- BRN 0019560
- ACon1_001979
- NINDS_000529
- SCHEMBL50066
- CCRIS 4348
- MFCD00010272
- SMR000112435
- NSC-95437
- 5 Methoxy Psoralen
- NCGC00017357-01
- NCGC00017357-04
- NCGC00017357-02
- AKOS000276715
- HY-N0370
- NCGC00178705-02
- UNII-4FVK84C92X
- 5-Methoxypsoralen with ultraviolet A therapy
- SW220008-1
- C01557
- NCGC00259906-01
- KBio2_006410
- HMS2268M24
- FT-0603416
- BRD-K12968785-001-02-6
- NCGC00091582-01
- D07521
- AB00052148_06
- SDCCGMLS-0066492.P001
- SR-05000002173-2
- 4FVK84C92X
- NCGC00178705-01
- EINECS 207-604-5
- Tox21_303255
- DB12216
- 7H-Furo[3, 4-methoxy-
- NCGC00256998-01
- MEGxp0_000990
- ACon0_000984
- DTXSID1025560
- SR-05000002173-3
- KBioSS_001274
- NCGC00017357-06
- AB00052148_07
- Bergapten, analytical standard
- NS00015832
- NCGC00017357-07
- NCGC00091582-04
- BDBM50067880
- DS-2970
- 5 methoxypsoralen
- KBio2_003842
- 4-Methoxy-7H-furo[3,2-g]benzopyran-7-one
- SY051831
- B2840
- 5-Methoxypsoralen; Bergapten
- 5-METHOXYPSORALEN [MART.]
- KBio2_001274
- DivK1c_000529
- Pentaderm (TN)
- ConMedNP.1779
- ConMedNP.1778
- Bergaptol; Me ether
- ConMedNP.1780
- MLSMR
- BRD-K12968785-001-12-5
- DB-051552
- STK333038
- BRD-K12968785-001-13-3
- FM05395
- 207-604-5
- 5-MOP;Bergapten;4-Methoxyfuro[3,2-?]benzopyrane-7-one;4-Methoxy-7H-furo[3,2-g]chromen-7-one
- HY-N0370R
- Bergapten (Standard)
- 5-Methoxypsoralen (Bergapten)
-
- MDL： MFCD00010272
- Inchi： 1S/C12H8O4/c1-14-12-7-2-3-11(13)16-10(7)6-9-8(12)4-5-15-9/h2-6H,1H3
- InChI Key： BGEBZHIAGXMEMV-UHFFFAOYSA-N
- SMILES： O1C=CC2=C1C=C1C(C=CC(=O)O1)=C2OC
Computed Properties
- Exact Mass: 216.04200
- Monoisotopic Mass: 216.042259
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 16
- Rotatable Bond Count: 1
- Complexity: 325
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: 2.3
- Topological Polar Surface Area: 48.7
- Molecular Weight: 216.19
Experimental Properties
- Color/Form: Powder
- Density: 1.1344 (rough estimate)
- Melting Point: 189.0 to 193.0 deg-C
- Boiling Point: 412.4℃ at 760 mmHg
- Flash Point: 203.2 °C
- Refractive Index: 1.4270 (estimate)
- Solubility: less than 1 mg/mL at 66° F (NTP, 1992)
- Stability/Shelf Life: Stable. Combustible. Incompatible with strong oxidizing agents. May be light sensitive.
- PSA: 52.58000
- LogP: 2.54780
- Merck: 1157
- Solubility: Not determined
- Vapor Pressure: 7.5X10-7 mm Hg at 25 °C (est)
Bergapten Security Information
-
Symbol:
- Prompt：dangerous
- Signal Word：Danger
- Hazard Statement： H334,H340,H350
- Warning Statement： P201,P261,P308+P313
- Hazardous Material transportation number：UN 1759
- WGK Germany：2
- Hazard Category Code： 45-43
- Safety Instruction： S36/37
- FLUKA BRAND F CODES：8-10
- RTECS：LV1300000
-
Hazardous Material Identification：
- Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
- Risk Phrases：R43
- Safety Term：S36/37
Bergapten Customs Data
- HS CODE：2932999099
- Customs Data：
China Customs Code:
2932999099Overview:
2932999099. Other heterocyclic compounds containing only oxygen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to
Summary:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Bergapten Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| MedChemExpress | HY-N0370-10mM*1mLinDMSO |
Bergapten |
484-20-8 | 99.77% | 10mM*1mLinDMSO |
￥550 | 2023-07-26 | |
| MedChemExpress | HY-N0370-500mg |
Bergapten |
484-20-8 | 99.94% | 500mg |
￥850 | 2024-05-25 | |
| MedChemExpress | HY-N0370-1g |
Bergapten |
484-20-8 | 99.94% | 1g |
￥335 | 2025-04-16 | |
| MedChemExpress | HY-N0370-5g |
Bergapten |
484-20-8 | 99.94% | 5g |
￥941 | 2025-04-16 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M101152-20mg |
Bergapten |
484-20-8 | ,>98.0% | 20mg |
￥247.90 | 2023-09-02 | |
| ChemFaces | CFN98766-20mg |
Bergapten |
484-20-8 | >=98% | 20mg |
$40 | 2021-07-22 | |
| HE FEI BO MEI SHENG WU KE JI YOU XIAN ZE REN GONG SI | BZP0426-20mg |
Bergapten |
484-20-8 | HPLC≥99% | 20mg |
￥480元 | 2023-09-15 | |
| DC Chemicals | DCF-008-20 mg |
Bergapten |
484-20-8 | >98%, Standard References Grade | 20mg |
$280.0 | 2022-03-01 | |
| S e l l e c k ZHONG GUO | S4239-50mg |
Bergapten |
484-20-8 | 99.93% | 50mg |
￥647.01 | 2023-09-15 | |
| ChemFaces | CFN98766-20mg |
Bergapten |
484-20-8 | >=98% | 20mg |
$40 | 2023-09-19 |
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Bergapten Related Literature
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Marco Kreidl,Matthias Harder,Matthias Rainer,Günther K. Bonn Anal. Methods 2020 12 4377
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E. Guardado Yordi,M. J. Matos,A. Pérez Martínez,A. C. Tornes,L. Santana,E. Molina,E. Uriarte Food Funct. 2017 8 2958
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Joana L. Rodrigues,Lígia R. Rodrigues Nat. Prod. Rep. 2021 38 869
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Andrey A. Buglak,Alexei I. Kononov New J. Chem. 2018 42 14424
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Ashraf Abdel-Fattah Mostafa,Chidambaram SathishKumar,Abdulaziz Abdulrahman Al-Askar,Shaban R. M. Sayed,Radhakrishnan SurendraKumar,Akbar Idhayadhulla RSC Adv. 2019 9 25533
Related Categories
- Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Coumarins and derivatives 5-methoxypsoralens
- Natural Products and Extracts Plant Extracts Plant based Magydaris pastinacea
- Natural Products and Extracts Plant Extracts Plant based Esenbeckia berlandieri
- Natural Products and Extracts Plant Extracts Plant based Deverra tortuosa
- Pharmaceutical and Biochemical Products Pharmaceutical Active Ingredients Standard Substances
Additional information on Bergapten
Bergapten (CAS No. 484-20-8): A Comprehensive Overview of Its Chemistry, Biology, and Emerging Applications
Bergapten, chemically known as 5-methoxypsoralen, is a naturally occurring furanocoumarin derivative with the chemical formula C??H??O?. This compound is primarily derived from plants of the genus Psoralea and has garnered significant attention in the fields of pharmaceutical chemistry, dermatology, and nutraceutical research due to its unique phototoxic and pharmacological properties. The systematic identification of this compound is facilitated by its unique CAS number CAS No. 484-20-8, which ensures standardized recognition and classification in scientific literature and industrial applications.
The molecular structure of Bergapten features a psoralen core substituted with a methoxy group at the 5-position, contributing to its distinct photoreactivity. This phototoxicity arises from its ability to absorb ultraviolet (UV) radiation, leading to the formation of reactive oxygen species that can induce damage in biological systems. Such properties have made Bergapten a subject of extensive research for its potential applications in treating various skin disorders, including vitiligo and psoriasis.
In recent years, the pharmacological profile of Bergapten has been further elucidated through cutting-edge research methodologies. Studies have demonstrated its role as an agonist for the aryl hydrocarbon receptor (AhR), a transcription factor involved in immune modulation and cell differentiation. This mechanism has opened new avenues for exploring Bergapten as a therapeutic agent in autoimmune diseases and inflammatory conditions. Additionally, preclinical trials have highlighted its potential in inhibiting the proliferation of certain cancer cell lines by inducing apoptosis through UV-induced oxidative stress.
The biosynthetic pathway of Bergapten involves a series of enzymatic reactions that convert furocoumarin precursors into the active compound. This process is highly regulated and influenced by environmental factors such as light exposure, which underscores the importance of plant-specific conditions in optimizing Bergapten production. Advances in metabolic engineering have enabled researchers to enhance the yield of this compound through genetic modifications, making it more feasible for large-scale production.
The therapeutic applications of Bergapten extend beyond dermatology into the realm of ophthalmology. Research has shown that topical application of Bergapten can be effective in managing certain ocular conditions by leveraging its phototoxic effects to target abnormal cell growth. Furthermore, ongoing studies are investigating its potential role in neuroprotection, suggesting that Bergapten may contribute to the development of novel treatments for neurodegenerative diseases.
The safety profile of Bergapten is another critical aspect that has been thoroughly evaluated in multiple clinical studies. While its phototoxic properties necessitate careful administration protocols, such as avoiding direct sunlight exposure during treatment, these precautions have been well-documented and standardized for clinical use. Regulatory agencies have reviewed these findings and have approved certain formulations containing Bergapten for specific medical applications, reinforcing its credibility as a viable therapeutic option.
In conclusion, Bergapten (CAS No. 484-20-8) represents a multifaceted compound with significant implications across various biomedical disciplines. Its unique chemical structure, coupled with its photoreactivity and biological activity, positions it as a promising candidate for innovative drug development. As research continues to uncover new therapeutic potentials and refine production methodologies, the future prospects for Bergapten appear exceptionally bright.
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