• 1. An astrophysically-relevant mechanism for amino acid enantiomer enrichment
  Stephen P. Fletcher,Richard B. C. Jagt,Ben L. Feringa Chem. Commun., 2007, 2578-2580
• 2. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
  Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378
• 3. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 4. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 5. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Dialkyl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Dialkyl ethers

Amino-PEG11-amine (CAS No. 479200-82-3): A Versatile Polymer for Advanced Biomedical Applications

Amino-PEG11-amine (CAS No. 479200-82-3) is a highly versatile and biocompatible polymer that has gained significant attention in the fields of biotechnology, pharmaceuticals, and materials science. This compound, also known as mPEG11-NH2, is a linear polyethylene glycol (PEG) chain terminated with an amine group at one end and a methoxy group at the other. The unique properties of Amino-PEG11-amine make it an ideal candidate for a wide range of applications, from drug delivery systems to surface modification and bioconjugation.

The polyethylene glycol (PEG) backbone of Amino-PEG11-amine imparts several advantageous characteristics, including excellent water solubility, low toxicity, and minimal immunogenicity. These properties are crucial for biomedical applications where biocompatibility and non-toxicity are paramount. The amine group at one end of the polymer provides a reactive site for chemical conjugation, enabling the attachment of various functional groups or biomolecules such as proteins, peptides, and small molecules.

Recent advancements in the field have further highlighted the potential of Amino-PEG11-amine. For instance, a study published in the Journal of Controlled Release demonstrated the use of Amino-PEG11-amine in the development of targeted drug delivery systems. By conjugating this polymer to nanoparticles, researchers were able to enhance the stability and circulation time of the nanoparticles in vivo, leading to improved therapeutic efficacy and reduced side effects.

In another application, Amino-PEG11-amine has been utilized in the surface modification of medical devices. A study in the Biomaterials Science journal reported that coating medical implants with Amino-PEG11-amine significantly reduced protein adsorption and cell adhesion, thereby minimizing the risk of biofilm formation and infection. This finding has significant implications for improving the longevity and safety of implantable devices.

The ability to functionalize Amino-PEG11-amine with various biomolecules also makes it a valuable tool in bioconjugation chemistry. For example, researchers have used this polymer to create antibody-drug conjugates (ADCs), where the amine group is used to link therapeutic antibodies to cytotoxic drugs. This approach has shown promise in cancer therapy by delivering drugs directly to tumor cells while minimizing damage to healthy tissues.

Beyond its biomedical applications, Amino-PEG11-amine has found use in materials science for the development of advanced coatings and hydrogels. The hydrophilic nature of PEG promotes excellent wettability and adhesion properties, making it suitable for applications such as wound dressings and tissue engineering scaffolds. A recent study in the Advanced Functional Materials journal demonstrated that hydrogels incorporating Amino-PEG11-amine exhibited enhanced mechanical strength and biocompatibility compared to traditional materials.

In summary, Amino-PEG11-amine (CAS No. 479200-82-3) is a highly versatile polymer with a wide range of applications in biotechnology, pharmaceuticals, and materials science. Its unique combination of biocompatibility, water solubility, and reactivity makes it an invaluable tool for researchers and developers working on advanced biomedical solutions. As ongoing research continues to uncover new possibilities, Amino-PEG11-amine is poised to play an increasingly important role in shaping the future of these fields.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)