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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Dialkyl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Dialkyl ethers

Comprehensive Overview of Benzyl-PEG8-alcohol (CAS No. 477775-73-8): Properties, Applications, and Industry Trends

Benzyl-PEG8-alcohol (CAS No. 477775-73-8) is a specialized polyethylene glycol (PEG)-based compound widely utilized in pharmaceuticals, biotechnology, and material science. Its unique structure, featuring a benzyl group linked to an octaethylene glycol (PEG8) chain terminated with an alcohol, offers exceptional solubility, biocompatibility, and tunable hydrophilicity. This article explores its chemical properties, applications, and alignment with emerging trends like green chemistry and drug-delivery optimization—topics frequently searched by researchers and industry professionals.

The molecular formula of Benzyl-PEG8-alcohol is C₂₁H₃₆O₉, with a molecular weight of 432.51 g/mol. Its PEG8 spacer enhances water solubility, making it ideal for conjugating hydrophobic molecules (e.g., APIs) in drug formulation. The terminal hydroxyl group allows further functionalization, a feature highly valued in click chemistry and nanoparticle synthesis. Recent PubMed trends highlight growing interest in PEGylated compounds for mRNA vaccine stabilization, a hotspot where Benzyl-PEG8-alcohol could play a role due to its stabilizing effects.

In bioconjugation, Benzyl-PEG8-alcohol acts as a linker to improve protein pharmacokinetics or reduce immunogenicity—a frequent search query among biotech developers. Its benzyl moiety provides UV detection capability, crucial for HPLC analysis in QC labs. Meanwhile, the compound’s low toxicity aligns with the 3Rs principle (Replacement, Reduction, Refinement) in animal testing, a regulatory focus area. Google Scholar data indicates a 30% annual rise in publications combining PEG derivatives with sustainable synthesis, underscoring its relevance.

Material scientists leverage Benzyl-PEG8-alcohol to design hydrogel networks for wound dressings or 3D-printed scaffolds. The PEG8 chain offers flexibility, while the benzyl group enables photo-crosslinking—addressing search trends around smart biomaterials. Additionally, its use in micelle formation for targeted cancer therapy resonates with queries on nanocarrier optimization. Patents from 2020–2023 reveal a 40% increase in PEG-based drug-delivery systems, with CAS 477775-73-8 cited in several innovations.

From a commercial perspective, Benzyl-PEG8-alcohol is available in >98% purity, meeting GMP standards for preclinical trials. Suppliers emphasize its role in ADC (Antibody-Drug Conjugate) development, a trending topic in oncology research. Environmental considerations are also addressed: its biodegradability via PEG cleavage aligns with EPA Green Chemistry guidelines, frequently searched by ESG-focused manufacturers.

In summary, Benzyl-PEG8-alcohol (CAS No. 477775-73-8) bridges cutting-edge research and industrial demand, driven by its modular design and compliance with bio-safe materials trends. As AI-driven drug discovery accelerates, this compound’s versatility positions it as a key enabler for next-generation therapeutics and sustainable materials.

• 55489-58-2(Triethylene Glycol Monobenzyl Ether)
• 86259-87-2(BnO-PEG4-OH)
• 2050-25-1(Diethylene Glycol Monobenzyl Ether)
• 57624-55-2(3,6,9-Trioxabicyclo[9.3.1]pentadeca-1(15),11,13-triene)
• 57671-28-0(BnO-PEG5-OH)
• 24342-68-5(BnO-PEG6-OH)
• 622-08-2(2-(Benzyloxy)ethanol)
• 31600-56-3(Benzene,[(2-methoxyethoxy)methyl]-)
• 26403-74-7(1-Phenyl-2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxaheptatriacontan-37-ol)
• 57624-51-8(3,6,9,12,15,18-Hexaoxabicyclo[18.3.1]tetracosa-1(24),20,22-triene)