• 1. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 2. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 3. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
• 4. Fe3O4 nanosphere@microporous organic networks: enhanced anode performances in lithium ion batteries through carbonization?
  Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726
• 5. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369

Benzenesulfonamide, N-cyclobutyl-4-nitro-

The compound with CAS No 477723-14-1, commonly referred to as Benzenesulfonamide, N-cyclobutyl-4-nitro-, is a significant molecule in the field of organic chemistry and pharmaceutical research. This compound has garnered attention due to its unique structural properties and potential applications in drug development. The benzenesulfonamide core of the molecule provides a stable framework, while the N-cyclobutyl and 4-nitro substituents introduce functional groups that enhance its reactivity and bioavailability.

Recent studies have highlighted the importance of benzenesulfonamides in medicinal chemistry, particularly as they serve as scaffolds for various bioactive compounds. The N-cyclobutyl group in this compound contributes to its lipophilicity, which is crucial for crossing biological membranes and interacting with target proteins. Additionally, the 4-nitro substituent introduces electron-withdrawing effects, which can modulate the electronic properties of the molecule, making it more suitable for specific biological interactions.

One of the most promising applications of Benzenesulfonamide, N-cyclobutyl-4-nitro- lies in its potential as a lead compound for anti-inflammatory and analgesic agents. Researchers have explored its ability to inhibit key enzymes involved in inflammatory pathways, such as cyclooxygenase (COX) and lipoxygenase (LOX). The compound's unique structure allows it to bind effectively to these enzyme targets, demonstrating potent anti-inflammatory activity in preclinical models.

Furthermore, the N-cyclobutyl group has been shown to enhance the compound's stability under physiological conditions, reducing its susceptibility to metabolic degradation. This property is essential for ensuring that the compound remains active in the body for an extended period, thereby improving therapeutic efficacy. The combination of these features makes Benzenesulfonamide, N-cyclobutyl-4-nitro- a valuable candidate for further drug development studies.

In terms of synthesis, the compound can be prepared through a multi-step process involving nucleophilic substitution and nitration reactions. The use of advanced synthetic techniques has enabled researchers to optimize the yield and purity of the compound, ensuring its suitability for both analytical and pharmacological studies.

Recent advancements in computational chemistry have also provided deeper insights into the molecular interactions of Benzenesulfonamide, N-cyclobutyl-4-nitro-. Molecular docking studies have revealed that the compound exhibits strong binding affinities with several drug targets, including G-protein coupled receptors (GPCRs) and kinase enzymes. These findings underscore its potential as a versatile tool in drug discovery research.

In conclusion, Benzenesulfonamide, N-cyclobutyl-4-nitro- (CAS No 477723-14-1) is a compelling molecule with a wealth of opportunities in pharmaceutical research. Its unique structure, combined with favorable pharmacokinetic properties and potent biological activity, positions it as a promising lead compound for developing novel therapeutic agents.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)