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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Dialkyl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Dialkyl ethers

Amino-PEG9-Amine (CAS No. 474082-35-4): An Advanced Bioconjugation Reagent

Amino-PEG9-Amine (CAS No. 474082-35-4) is a versatile and highly functional polymer that has gained significant attention in the fields of biotechnology and pharmaceutical research. This compound, also known as NH2-PEG9-NH2, is a linear polyethylene glycol (PEG) derivative with amine groups at both termini. The unique properties of Amino-PEG9-Amine make it an ideal reagent for various bioconjugation applications, including the modification of proteins, peptides, and nanoparticles.

The chemical structure of Amino-PEG9-Amine consists of a central PEG chain with nine ethylene oxide units, flanked by amine groups. The PEG segment provides excellent water solubility and biocompatibility, while the terminal amine groups offer reactive sites for conjugation with other molecules. This dual functionality allows for precise control over the conjugation process, enabling researchers to tailor the properties of biomolecules and materials for specific applications.

Recent advancements in the field have highlighted the potential of Amino-PEG9-Amine in enhancing the stability and bioavailability of therapeutic agents. For instance, a study published in the Journal of Medicinal Chemistry demonstrated that PEGylation using Amino-PEG9-Amine significantly improved the pharmacokinetic profile of a recombinant protein, leading to prolonged circulation time and reduced immunogenicity. This finding underscores the importance of PEGylation in drug delivery systems and highlights the role of Amino-PEG9-Amine as a key reagent in this process.

In addition to its use in protein modification, Amino-PEG9-Amine has also been explored for its potential in nanoparticle functionalization. A research team from the University of California, Berkeley, reported that coating gold nanoparticles with Amino-PEG9-Amine enhanced their stability in biological environments and facilitated their targeted delivery to cancer cells. The amine groups on the PEG chain can be further modified with targeting ligands or therapeutic agents, making these nanoparticles highly versatile platforms for diagnostic and therapeutic applications.

The versatility of Amino-PEG9-Amine extends beyond its use in biotechnology and pharmaceuticals. In materials science, this compound has been utilized to improve the performance of hydrogels and other biomaterials. A study published in Biomacromolecules showed that incorporating Amino-PEG9-Amine into hydrogel networks increased their mechanical strength and biocompatibility, making them suitable for tissue engineering and regenerative medicine applications.

The synthesis of Amino-PEG9-Amine involves a well-established chemical process that ensures high purity and consistent quality. The compound is typically prepared by reacting methoxy-polyethylene glycol (mPEG) with an appropriate amine source under controlled conditions. The resulting product is purified through multiple steps to remove any impurities and ensure its suitability for sensitive biological applications.

In conclusion, Amino-PEG9-Amine (CAS No. 474082-35-4) is a powerful tool in the arsenal of researchers working at the intersection of chemistry, biology, and materials science. Its unique combination of water solubility, biocompatibility, and reactive functionality makes it an invaluable reagent for a wide range of applications, from drug delivery to tissue engineering. As research continues to uncover new possibilities for PEG-based materials, the importance of compounds like Amino-PEG9-Amine is likely to grow even further.

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