• 1. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 2. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 3. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
• 4. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 5. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

1-(5-Methyl-1,2-Oxazol-3-yl)Propan-1-one: A Comprehensive Overview

1-(5-Methyl-1,2-Oxazol-3-yl)Propan-1-one (CAS No. 473732-48-8) is a chemical compound that has garnered significant attention in the fields of organic chemistry and pharmacology due to its unique structural properties and potential applications. This compound belongs to the class of oxazole derivatives, which are known for their versatility in organic synthesis and their role in various biological activities. The molecule consists of a propanone group attached to a 5-methyl-substituted oxazole ring, making it a valuable intermediate in the synthesis of more complex molecules.

The oxazole ring is a five-membered heterocyclic structure containing one oxygen and one nitrogen atom. In this compound, the oxazole ring is further substituted with a methyl group at the 5-position, which adds to its stability and reactivity. The propanone group (a ketone with two methyl groups) contributes to the molecule's lipophilicity, making it an interesting candidate for drug design and development. Recent studies have highlighted the potential of oxazole derivatives in modulating various biological pathways, including those involved in inflammation, cancer, and neurodegenerative diseases.

One of the most notable aspects of 1-(5-Methyl-1,2-Oxazol-3-yl)Propan-1-one is its role as an intermediate in the synthesis of bioactive compounds. Researchers have employed this compound as a building block for constructing more complex molecules with enhanced pharmacological properties. For instance, its use in the synthesis of Hsp90 inhibitors has shown promise in targeting heat shock protein 90, a key player in cancer cell survival and proliferation. This highlights the importance of understanding the structural features and reactivity of this compound in drug discovery.

Recent advancements in synthetic chemistry have also led to innovative methods for synthesizing 1-(5-Methyl-1,2-Oxazol-3-yl)Propan-1-one. Traditionally, oxazole derivatives are synthesized through condensation reactions involving aldehydes or ketones with amino alcohols or other nitrogen-containing compounds. However, modern approaches often utilize microwave-assisted synthesis or catalytic methods to enhance reaction efficiency and selectivity. These methods not only reduce reaction times but also improve yields, making them more suitable for large-scale production.

The biological activity of this compound has been extensively studied in vitro and in vivo models. Experimental data suggest that 1-(5-Methyl-1,2-Oxazol-3-yl)Propan-1-one exhibits moderate anti-inflammatory and antioxidant properties, which could be harnessed for developing therapeutic agents against chronic diseases. Furthermore, its ability to modulate cellular signaling pathways makes it a potential candidate for targeting diseases such as Alzheimer's disease and Parkinson's disease.

In terms of safety and handling, this compound is classified as non-hazardous under normal conditions. However, it is recommended to handle it with appropriate personal protective equipment (PPE) due to its potential irritant effects on the eyes and skin. Storage should be carried out in a cool, dry place away from direct sunlight to prevent degradation.

Looking ahead, the future of 1-(5-Methyl-1,2-Oxazol-3-yl)Propan-1-one lies in its continued exploration as a versatile building block for drug development. Ongoing research aims to uncover new synthetic routes and biological applications that could further enhance its utility in the pharmaceutical industry. As advancements in medicinal chemistry continue to unfold, this compound remains a cornerstone for innovative therapeutic strategies.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)