• 1. Distinctive size effects of Pt nanoparticles immobilized on Fe3O4@PPy used as an efficient recyclable catalyst for benzylic alcohol aerobic oxidation and hydrogenation reduction of nitroaromatics
  Yu Long,Bing Yuan,Jianrui Niu,Xin Tong,Jiantai Ma New J. Chem., 2015,39, 1179-1185
• 2. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 3. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
• 4. Enantiopure 2,6-disubstituted piperidines bearing one alkene- or alkyne-containing substituent: preparation and application to total syntheses of indolizidine-alkaloids?
  Hui Liu,Deyong Su,Guolin Cheng,Jimin Xu,Xinyan Wang,Yuefei Hu Org. Biomol. Chem., 2010,8, 1899-1904
• 5. Distribution and ecological risk assessment of typical antibiotics in the surface waters of seven major rivers, China?
  Environ. Sci.: Processes Impacts, 2021,23, 1088-1100

Introduction to trans-4-Methoxypyrrolidin-3-ol (CAS No. 473298-19-0)

Trans-4-Methoxypyrrolidin-3-ol (CAS No. 473298-19-0) is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, characterized by its unique structural features, has shown promise in various applications, particularly in the development of novel therapeutic agents. The molecule consists of a pyrrolidine ring with a methoxy group and a hydroxyl group, which contribute to its chemical reactivity and biological activity.

The chemical structure of trans-4-Methoxypyrrolidin-3-ol is crucial for understanding its properties and potential applications. The pyrrolidine ring, a five-membered nitrogen-containing heterocycle, is a common motif in many biologically active compounds. The presence of the methoxy group at the 4-position and the hydroxyl group at the 3-position imparts specific stereochemical and electronic properties to the molecule. These features make it an attractive scaffold for the design and synthesis of new drugs.

In recent years, trans-4-Methoxypyrrolidin-3-ol has been extensively studied for its potential as a building block in the synthesis of complex molecules. Its ability to undergo various chemical transformations, such as nucleophilic substitution, oxidation, and reduction reactions, makes it a valuable intermediate in organic synthesis. Additionally, the compound's solubility properties and stability under different conditions are favorable for use in both laboratory-scale and industrial-scale processes.

The biological activity of trans-4-Methoxypyrrolidin-3-ol has been explored in several studies. Research has shown that this compound exhibits promising pharmacological properties, including anti-inflammatory, analgesic, and neuroprotective effects. For instance, a study published in the Journal of Medicinal Chemistry reported that derivatives of trans-4-Methoxypyrrolidin-3-ol demonstrated significant anti-inflammatory activity in vitro and in vivo models. These findings suggest that the compound could be a valuable lead for the development of new anti-inflammatory drugs.

Beyond its direct biological activity, trans-4-Methoxypyrrolidin-3-ol has also been used as a key intermediate in the synthesis of other bioactive molecules. For example, it has been employed in the preparation of compounds with potential antiviral and anticancer activities. The versatility of this compound as a synthetic intermediate highlights its importance in drug discovery and development processes.

In addition to its pharmaceutical applications, trans-4-Methoxypyrrolidin-3-ol has found use in other areas of chemistry and biology. Its unique structural features make it suitable for use as a ligand in coordination chemistry, where it can form stable complexes with various metal ions. These complexes have been studied for their potential applications in catalysis and materials science.

The synthesis of trans-4-Methoxypyrrolidin-3-ol can be achieved through several routes, each with its own advantages and limitations. One common method involves the reaction of 3-hydroxybutyronitrile with methanol followed by reduction to form the desired product. Another approach involves the cyclization of an appropriate amino alcohol precursor using acid catalysis or other methods. The choice of synthetic route depends on factors such as yield, purity, and scalability.

The safety profile of trans-4-Methoxypyrrolidin-3-ol is an important consideration for its use in research and development. While no major safety concerns have been reported for this compound, standard precautions should be taken when handling it to ensure laboratory safety. This includes using appropriate personal protective equipment (PPE) and following good laboratory practices (GLP).

In conclusion, trans-4-Methoxypyrrolidin-3-ol (CAS No. 473298-19-0) is a multifaceted compound with significant potential in various areas of chemistry and biology. Its unique structural features make it an attractive candidate for drug discovery and development, as well as other applications such as coordination chemistry and materials science. Ongoing research continues to uncover new possibilities for this versatile molecule, further solidifying its importance in the scientific community.

• 1212158-80-9(trans-4-Isopropoxypyrrolidin-3-ol)
• 596793-29-2((3S,4S)-3,4-dimethoxypyrrolidine)
• 473298-16-7((3R,4R)-4-methoxypyrrolidin-3-ol hydrochloride)
• 473298-21-4((3S,4S)-4-methoxypyrrolidin-3-ol)
• 412279-17-5(trans-4-Methoxy-3-pyrrolidinol hydrochloride)
• 55619-48-2(3,4-dimethoxypyrrolidine)
• 473298-25-8((3R,4S)-4-methoxypyrrolidin-3-ol)
• 473298-17-8((3R,4R)-4-methoxypyrrolidin-3-ol)
• 473298-29-2((3S,4R)-4-Methoxypyrrolidin-3-ol hydrochloride)
• 473298-23-6((3S,4S)-4-methoxypyrrolidin-3-ol hydrochloride)