Cas no 469-32-9 (Hamamelitannin)

Hamamelitannin is a hydrolyzable tannin derived from the bark and leaves of Hamamelis virginiana (witch hazel). It is characterized by its dimeric structure, consisting of two hamamelose units linked to gallic acid. This compound exhibits notable antioxidant, anti-inflammatory, and astringent properties, making it valuable in dermatological and cosmetic applications. Its ability to scavenge free radicals and modulate inflammatory pathways contributes to its efficacy in soothing irritated skin and reducing oxidative stress. Hamamelitannin also demonstrates potential antimicrobial activity, further enhancing its utility in topical formulations. Its natural origin and multifunctional profile make it a compound of interest in both pharmaceutical and personal care research.
Hamamelitannin structure
Hamamelitannin structure
Product Name:Hamamelitannin
CAS No:469-32-9
MF:C20H20O14
MW:484.364407539368
MDL:MFCD33023081
CID:330397
PubChem ID:44584241
Update Time:2025-05-21

Hamamelitannin Chemical and Physical Properties

Names and Identifiers

    • D-Ribose,2-C-[[(3,4,5-trihydroxybenzoyl)oxy]methyl]-, 5-(3,4,5-trihydroxybenzoate)
    • Root of Chinese Witchhazel
    • HAMAMELITANNIN(P)
    • HAMAMELITANNIN
    • 2,3-Digalloylglucose
    • 2',5-DigalloylhaMaMelofuranose
    • 2',5-digalloylhamamelose
    • hamamelitanin
    • HAMAMELOFURANOSE 2',5-DIGALLATE
    • O5-Galloyl-2-galloyloxymethyl-D-ribose
    • 2-C-(Hydroxymethyl)-D-ribofuranose 2′,5-digallate
    • Hamamelofuranose 2′,5-digallate
    • NSC77009
    • [3,4,5-trihydroxy-4-[(3,4,5-trihydroxybenzoyl)oxymethyl]oxolan-2-yl]methyl 3,4,5-trihydroxybenzoate
    • (2,3,4-trihydroxy-5-{[(3,4,5-trihydroxyphenyl)carbonyloxy]methyl}oxolan-3-yl)methyl 3,4,5-trihydroxybenzoate
    • ((2S,3S,4S)-3,4,5-trihydroxytetrahydrofuran-2,4-diyl)bis(methylene) bis(3,4,5-trihydroxybenzoate)
    • MFCD33023081
    • 469-32-9
    • CHEBI:191119
    • Q15632711
    • Hamamelofuranose 2'5'-digallate
    • Hamamelofuranose2,5-digallate
    • [(2S,3S,4S)-3,4,5-trihydroxy-4-[(3,4,5-trihydroxybenzoyl)oxymethyl]oxolan-2-yl]methyl 3,4,5-trihydroxybenzoate
    • CHEMBL465414
    • FS-7252
    • DTXSID10963692
    • FT-0632174
    • 5-O-(3,4,5-Trihydroxybenzoyl)-2-C-{[(3,4,5-trihydroxybenzoyl)oxy]methyl}pentose
    • EINECS 207-416-3
    • Gallic acid, 21,5-diester with 2-C-(hydroxymethyl)-D-ribose
    • NS00043231
    • HAMAMELITANNIN [MI]
    • 2-C-((Galloyloxy)methyl)-D-ribose 5-gallate
    • 2',5-DI-O-GALLOYL-D-HAMAMELOSE
    • hamamelitannin (open form)
    • CS-0032127
    • UNII-Z4320A2K26
    • HY-N4117
    • Q27294967
    • Z4320A2K26
    • AKOS040760441
    • D-RIBOSE, 2-C-(((3,4,5-TRIHYDROXYBENZOYL)OXY)METHYL)-, 5-(3,4,5-TRIHYDROXYBENZOATE)
    • 2',5'-Di-O-galloyl D-hamamelose
    • [(2R,3R,4R)-3,4,5-trihydroxy-4-[(3,4,5-trihydroxybenzoyl)oxymethyl]tetrahydrofuran-2-yl]methyl 3,4,5-trihydroxybenzoate
    • Hamamelitannin, >=98.0% (HPLC)
    • SCHEMBL934789
    • CHEMBL491592
    • A827115
    • 2-C-(Hydroxymethyl)-D-ribofuranose 2',5-digallate
    • BDBM50259992
    • [(2R,3R,4R)-3,4,5-trihydroxy-4-[(3,4,5-trihydroxybenzoyl)oxymethyl]oxolan-2-yl]methyl 3,4,5-trihydroxybenzoate
    • SCHEMBL14339420
    • NSC-77009
    • D-Ribose, 2-C-[[(3,4,5-trihydroxybenzoyl)oxy]methyl]-, 5-(3,4,5-trihydroxybenzoate); Hamamelitannin (6CI,7CI); Ribose, 2-C-(hydroxymethyl)-, 21,5-digallate, D- (8CI); Gallic acid, 21,5-diester with 2-C-(hydroxymethyl)-D-ribose (8CI); 2',5-Di-O-galloyl-D-hamamelose
    • FEPAFOYQTIEEIS-WZKFEGCESA-N
    • Hamamelitannin
    • MDL： MFCD33023081
    • Inchi： 1S/C20H20O14/c21-9-1-7(2-10(22)14(9)25)17(28)32-5-13-16(27)20(31,19(30)34-13)6-33-18(29)8-3-11(23)15(26)12(24)4-8/h1-4,13,16,19,21-27,30-31H,5-6H2/t13-,16-,19?,20-/m0/s1
    • InChI Key： FEPAFOYQTIEEIS-WZKFEGCESA-N
    • SMILES： O1C([C@](COC(C2C=C(C(=C(C=2)O)O)O)=O)([C@H]([C@@H]1COC(C1C=C(C(=C(C=1)O)O)O)=O)O)O)O

Computed Properties

  • Exact Mass: 484.08500
  • Monoisotopic Mass: 484.08530531 g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 9
  • Hydrogen Bond Acceptor Count: 14
  • Heavy Atom Count: 34
  • Rotatable Bond Count: 8
  • Complexity: 710
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 3
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 244
  • Molecular Weight: 484.4
  • XLogP3: -1.1

Experimental Properties

  • Density: 1.771±0.06 g/cm3 (20 oC 760 Torr),
  • Melting Point: 145-147 oC
  • Boiling Point: 947.5°Cat760mmHg
  • Flash Point: 331°C
  • Refractive Index: 1.745
  • Solubility: Slightly soluble (6.3 g/l) (25 o C),
  • PSA: 243.90000
  • LogP: -1.25680
  • Specific Rotation: D19 +32.6° (c = 1.5)

Hamamelitannin Security Information

  • Hazardous Material transportation number：NONH for all modes of transport
  • WGK Germany：3
  • FLUKA BRAND F CODES：3-10-21
  • Storage Condition：2-8°C

Hamamelitannin Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
abcr
AB166376-20 mg
Hamamelitannin, 95%; .
 469-32-9 95%
20 mg
 €388.80 2023-07-20
Chengdu Biopurify Phytochemicals Ltd
BP0695-10mg
Hamamelitannin
 469-32-9 98%
10mg
 $290 2023-09-20
Chengdu Biopurify Phytochemicals Ltd
BP0695-20mg
Hamamelitannin
 469-32-9 98%
20mg
 $450 2023-09-20
ChemScence
CS-0032127-1mg
Hamamelitannin
 469-32-9
1mg
 $120.0 2022-04-27
ChemScence
CS-0032127-5mg
Hamamelitannin
 469-32-9
5mg
 $300.0 2022-04-27
SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.
H99270-10mg
HAMAMELITANNIN
 469-32-9 ,HPLC≥95%
10mg
 ￥2468.0 2023-09-07
SHANG HAI TAO SHU Biotechnology Co., Ltd.
TN1722-1 mg
Hamamelitannin
 469-32-9
1mg
 ￥987.00 2022-04-26
MedChemExpress
HY-N4117-1mg
Hamamelitannin
 469-32-9 99.43%
1mg
 ￥1200 2025-04-16
MedChemExpress
HY-N4117-5mg
Hamamelitannin
 469-32-9 99.43%
5mg
 ￥2500 2025-04-16
TRC
H175460-0.5mg
Hamamelitannin
 469-32-9
0.5mg
 $ 50.00 2022-06-04

Hamamelitannin Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:469-32-9)Hamamelitannin
Order Number:A827115
Stock Status:in Stock
Quantity:5mg
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 05:25
Price ($):414.0
NewCan Biotech Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:469-32-9)HaMaMelitannin
Order Number:NC29163
Stock Status:
Quantity:10g
Purity:97%
Pricing Information Last Updated:Friday, 18 July 2025 16:05
Price ($):Price inquiry

Hamamelitannin Related Literature

Related Categories

Additional information on Hamamelitannin

Hamamelitannin (CAS No. 469-32-9): A Comprehensive Overview of Its Properties, Applications, and Market Trends

Hamamelitannin (CAS No. 469-32-9) is a naturally occurring hydrolyzable tannin derived from the bark and leaves of the witch hazel plant (Hamamelis virginiana). This bioactive compound has garnered significant attention in recent years due to its potent antioxidant, anti-inflammatory, and skin-protective properties. As consumer demand for natural skincare ingredients and plant-based therapeutics continues to rise, Hamamelitannin has emerged as a key player in the cosmeceutical and pharmaceutical industries.

The chemical structure of Hamamelitannin consists of a glucose core esterified with two gallic acid units, making it a member of the ellagitannin family. This unique configuration contributes to its remarkable biological activities, including free radical scavenging and metal chelation. Recent studies published in Journal of Natural Products highlight its superior antioxidant capacity compared to many synthetic alternatives, making it particularly valuable for anti-aging formulations and UV protection products.

In the cosmetics industry, Hamamelitannin is increasingly incorporated into serums, creams, and toners targeting sensitive skin and rosacea-prone complexions. Its ability to strengthen capillary walls and reduce redness aligns perfectly with current consumer searches for "natural remedies for facial redness" and "plant-based solutions for sensitive skin". Leading skincare brands now feature witch hazel extracts rich in Hamamelitannin as their star ingredients, capitalizing on the growing clean beauty movement.

Beyond skincare, research suggests promising applications of Hamamelitannin in wound healing and oral care products. Its astringent properties make it effective in mouthwashes for gum health, addressing popular consumer concerns about "natural alternatives to chemical mouthwashes". The compound's antibacterial activity against oral pathogens has been documented in several peer-reviewed studies, supporting its use in holistic dental care formulations.

The global market for Hamamelitannin is experiencing steady growth, driven by increasing awareness of its multifunctional benefits. Market analysis reveals particular demand in North America and Europe, where consumers actively search for "clinical studies on witch hazel tannins" and "evidence-based natural ingredients". Suppliers are responding with standardized extracts containing precise Hamamelitannin concentrations to meet formulation requirements for cosmetic chemists and nutraceutical developers.

From a sustainability perspective, Hamamelitannin production aligns with eco-conscious manufacturing trends. The witch hazel plant requires minimal pesticides and thrives in diverse climates, making it an attractive source for green chemistry applications. This environmental profile resonates with consumers searching for "sustainable bioactive compounds" and "ethically sourced plant extracts".

Ongoing research continues to uncover new potential for Hamamelitannin, including investigations into its metabolic effects and possible role in gut health. As scientific understanding expands, we can anticipate broader applications of this versatile compound across functional foods, dietary supplements, and medical devices. The future looks bright for Hamamelitannin as both consumers and researchers increasingly recognize its value in health and wellness applications.

469-32-9 (Hamamelitannin) Related Products

Recommended suppliers
Amadis Chemical Company Limited
(CAS:469-32-9)Hamamelitannin
A827115
Purity:99%
Quantity:5mg
Price ($):414.0
Email
NewCan Biotech Limited
(CAS:469-32-9)HaMaMelitannin
NC29163
Purity:97%
Quantity:10g
Price ($):Inquiry
Email