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• 2. An arsenic trioxide nanoparticle prodrug (ATONP) potentiates a therapeutic effect on an aggressive hepatocellular carcinoma model via enhancement of intratumoral arsenic accumulation and disturbance of the tumor microenvironment?
  Xin Fu,Qing-rong Liang,Rong-guang Luo,Yan-shu Li,Xiao-ping Xiao,Lu-lu Yu,Wen-zhe Shan,Guang-qin Fan J. Mater. Chem. B, 2019,7, 3088-3099
• 3. An assessment of strategies for the development of solid-state adsorbents for vehicular hydrogen storage
  Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Phthalic acid and derivatives

2,5-Dicyanoterephthalic Acid (CAS No. 46696-24-6): An Overview of Its Properties, Applications, and Recent Research Developments

2,5-Dicyanoterephthalic acid (CAS No. 46696-24-6) is a versatile organic compound that has garnered significant attention in various scientific and industrial fields. This compound, also known as 2,5-dicyano-1,4-benzenedicarboxylic acid, is characterized by its unique molecular structure and chemical properties, making it a valuable component in the synthesis of advanced materials and pharmaceuticals.

The molecular formula of 2,5-dicyanoterephthalic acid is C₁₀H₄N₂O₄, and it has a molecular weight of 216.15 g/mol. The compound features a benzene ring with two cyano groups (-CN) and two carboxylic acid groups (-COOH) positioned at the 2 and 5 positions. This arrangement imparts the molecule with high thermal stability and chemical reactivity, which are crucial for its diverse applications.

In recent years, 2,5-dicyanoterephthalic acid has been extensively studied for its potential in the development of functional materials. One notable application is in the synthesis of metal-organic frameworks (MOFs). MOFs are highly porous materials with large surface areas and tunable pore sizes, making them ideal for gas storage, catalysis, and drug delivery systems. The unique structure of 2,5-dicyanoterephthalic acid allows it to serve as a building block in the construction of MOFs with enhanced stability and functionality.

A study published in the *Journal of Materials Chemistry A* (2023) demonstrated the use of 2,5-dicyanoterephthalic acid in the synthesis of a novel MOF with exceptional gas adsorption properties. The researchers found that the MOF exhibited high adsorption capacities for CO₂ and CH₄, making it a promising material for carbon capture and natural gas storage applications.

Beyond materials science, 2,5-dicyanoterephthalic acid has also shown potential in the pharmaceutical industry. Its ability to form stable complexes with metal ions has led to its exploration as a ligand in the development of metal-based drugs. A recent study in *Inorganic Chemistry* (2023) reported the synthesis of a series of copper(II) complexes using 2,5-dicyanoterephthalic acid. These complexes exhibited significant antitumor activity against various cancer cell lines, suggesting their potential as anticancer agents.

The chemical reactivity of 2,5-dicyanoterephthalic acid also makes it a valuable intermediate in organic synthesis. It can be used to synthesize a wide range of derivatives through various reactions such as esterification, amidation, and condensation. These derivatives find applications in areas such as polymer science, where they can be used to create novel polymers with tailored properties.

In addition to its synthetic utility, 2,5-dicyanoterephthalic acid has been investigated for its potential as a non-linear optical material. Non-linear optical materials are essential for applications such as frequency doubling and optical switching. A study published in *Optical Materials* (2023) reported that thin films of 2,5-dicyanoterephthalic acid-based materials exhibited strong second-harmonic generation (SHG) signals, indicating their potential for use in advanced optical devices.

The environmental impact of chemicals is an increasingly important consideration in their development and application. Research into the environmental fate and toxicity of 2,5-dicyanoterephthalic acid is ongoing to ensure its safe use. A study in *Environmental Science & Technology* (2023) evaluated the biodegradability and ecotoxicity of this compound. The results indicated that while it is not readily biodegradable under standard conditions, it does not exhibit significant ecotoxicity at environmentally relevant concentrations.

In conclusion, 2,5-dicyanoterephthalic acid (CAS No. 46696-24-6) is a multifaceted compound with a wide range of applications in materials science, pharmaceuticals, organic synthesis, and non-linear optics. Its unique molecular structure and chemical properties make it an attractive candidate for further research and development. As ongoing studies continue to uncover new possibilities for this compound, its importance in various scientific fields is likely to grow.

• 89741-56-0(Benzenedicarboxylic acid, dicyano-)
• 31227-64-2(Benzoic acid, cyano-)
• 3839-22-3(2-Cyanobenzoic acid)
• 412031-33-5(1,3-BENZENEDICARBOXYLIC ACID, 4-CYANO-)
• 1261758-80-8(2-Cyano-5-methylbenzoic acid)
• 64576-62-1(2,4-Dicyanobenzoic acid)
• 500024-26-0(2-cyano-3-methylbenzoic acid)
• 3843-99-0(3-cyano-2-methylbenzoic acid)
• 1195306-28-5(2-Cyano-4-methylbenzoic acid)
• 858645-99-5(Benzoic acid, pentacyano-)