• 1. Supramolecular isomerism and structural flexibility in coordination networks sustained by cadmium rod building blocks
  Yassin H. Andaloussi,Andrey A. Bezrukov,Debobroto Sensharma,Michael J. Zaworotko CrystEngComm 2023 25 4175
• 2. Isolation, biological activity and synthesis of the natural product ellipticine and related pyridocarbazoles
  Charlotte M. Miller,Florence O. McCarthy RSC Adv. 2012 2 8883
• 3. Synthesis and antitubercular activity of 1- and 3-substituted benzo[g]isoquinoline-5,10-diones
  Robert J. Smets,Eveline Torfs,Filip Lemière,Paul Cos,Davie Cappoen,Kourosch Abbaspour Tehrani Org. Biomol. Chem. 2019 17 2923
• 4. Recent progress in the chemistry of indole alkaloids and mould metabolites
  J. E. Saxton Nat. Prod. Rep. 1984 1 21
• 5. Organic chemistry
  J. Chem. Soc. Abstr. 1905 88 A165

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

3,4-Pyridinedicarboxylic Anhydride: A Comprehensive Overview

3,4-Pyridinedicarboxylic anhydride, also known by its CAS number 4664-08-8, is a significant compound in the field of organic chemistry. This compound is a derivative of pyridine, a six-membered aromatic heterocycle with one nitrogen atom. The anhydride form of 3,4-pyridinedicarboxylic acid is widely recognized for its versatile applications in both academic research and industrial settings. Recent studies have highlighted its potential in drug discovery, material science, and catalytic processes, making it a focal point for researchers worldwide.

The structure of 3,4-pyridinedicarboxylic anhydride consists of two carboxyl groups attached to the 3 and 4 positions of the pyridine ring. This arrangement imparts unique electronic properties to the molecule, enabling it to participate in various chemical reactions. The compound is synthesized through a series of well-established methods, including oxidation and cyclization processes. Recent advancements in synthetic chemistry have led to more efficient and environmentally friendly routes for its production, which has significantly enhanced its accessibility for large-scale applications.

In terms of physical properties, 3,4-pyridinedicarboxylic anhydride is a crystalline solid with a melting point of approximately 180°C. Its solubility in common solvents such as water and organic solvents varies depending on the solvent's polarity and the compound's functional groups. This property makes it suitable for use in various solution-based reactions and purification techniques. Moreover, the compound exhibits moderate stability under standard conditions but can undergo hydrolysis in the presence of water or strong acids/bases to regenerate the corresponding dicarboxylic acid.

The applications of 3,4-pyridinedicarboxylic anhydride are vast and diverse. In pharmaceutical research, it serves as a valuable building block for constructing bioactive molecules with potential therapeutic effects. For instance, recent studies have explored its role in designing inhibitors for enzymes involved in cancer progression and neurodegenerative diseases. Its ability to form stable amide bonds with amino acids or other nitrogen-containing compounds makes it an ideal candidate for drug design.

In material science, 3,4-pyridinedicarboxylic anhydride has been employed as a precursor for synthesizing advanced materials such as polyamides and metal-organic frameworks (MOFs). These materials exhibit exceptional mechanical strength and thermal stability, making them suitable for use in high-performance applications like aerospace components and energy storage devices. Furthermore, the compound's aromaticity and electron-withdrawing groups contribute to its potential as a ligand in coordination chemistry, enabling the formation of metal complexes with unique magnetic and catalytic properties.

The latest research on 3,4-pyridinedicarboxylic anhydride has focused on its role in catalytic processes. Scientists have discovered that when used as a catalyst or catalyst precursor, it can significantly enhance the efficiency of various organic transformations. For example, recent studies have demonstrated its effectiveness in promoting aldol reactions and Michael additions under mild conditions. These findings underscore its potential as a sustainable alternative to traditional catalysts, particularly in green chemistry initiatives.

In conclusion, 3,4-pyridinedicarboxylic anhydride (CAS No: 4664-08-8) is a multifaceted compound with remarkable chemical properties and diverse applications. Its role as a building block in organic synthesis, coupled with its suitability for advanced materials and catalytic processes, positions it as a key player in modern chemical research. As ongoing studies continue to uncover new avenues for its utilization, this compound is poised to make even greater contributions to scientific progress.

• 58997-11-8(Ethyl 3-methylisonicotinate)
• 1678-52-0(3,4-diethyl pyridine-3,4-dicarboxylate)
• 1796-83-4(3,4-dimethyl pyridine-3,4-dicarboxylate hydrochloride)
• 33402-75-4(Methyl 4-methylnicotinate)
• 24202-79-7(3-(methoxycarbonyl)pyridine-4-carboxylic acid)
• 1211579-85-9(Methyl 4-formylpyridine-3-carboxylate)
• 16837-38-0(Nicotinic anhydride)
• 55314-29-9(ethyl 4-methylpyridine-3-carboxylate)
• 2199-49-7(Ethyl 4-methyl-1h-pyrrole-3-carboxylate)
• 41969-71-5(Diethyl 1H-Pyrrole-3,4-dicarboxylate)