• 1. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 2. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 3. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 4. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 5. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212

Introduction to 3-(4-bromophenyl)-1H-pyrazole-5-carboxylic acid (CAS No. 46413-66-5)

3-(4-bromophenyl)-1H-pyrazole-5-carboxylic acid, identified by the chemical compound code CAS No. 46413-66-5, is a significant intermediate in the field of pharmaceutical chemistry and medicinal research. This compound belongs to the pyrazole class, which has garnered considerable attention due to its diverse biological activities and structural versatility. The presence of a 4-bromophenyl substituent and a carboxylic acid functional group at the 5-position of the pyrazole ring imparts unique chemical properties that make it a valuable scaffold for drug discovery and development.

The pyrazole core is a six-membered heterocyclic aromatic ring containing two nitrogen atoms at positions 1 and 5. This structural motif is known for its ability to interact with biological targets such as enzymes and receptors, making it a privileged scaffold in medicinal chemistry. The introduction of a 4-bromophenyl group at the 3-position of the pyrazole ring enhances its reactivity and binding affinity, which can be exploited for designing novel therapeutic agents. Additionally, the carboxylic acid moiety at the 5-position provides opportunities for further functionalization, allowing chemists to tailor the compound’s properties for specific applications.

Recent advancements in synthetic chemistry have enabled more efficient and scalable methods for the preparation of 3-(4-bromophenyl)-1H-pyrazole-5-carboxylic acid. These methods often involve multi-step organic transformations, including condensation reactions, bromination, and carboxylation, which are optimized to maximize yield and purity. The compound’s stability under various reaction conditions makes it a preferred choice for researchers aiming to explore new pharmacophores.

In the realm of pharmaceutical research, 3-(4-bromophenyl)-1H-pyrazole-5-carboxylic acid has been investigated for its potential as an anti-inflammatory agent, an antioxidant, and an antimicrobial agent. The bromine atom in the 4-bromophenyl group facilitates further derivatization through cross-coupling reactions such as Suzuki-Miyaura or Buchwald-Hartwig couplings, enabling the introduction of diverse functional groups onto the pyrazole scaffold. This flexibility has led to the synthesis of numerous analogs with enhanced biological activity.

One of the most compelling aspects of 3-(4-bromophenyl)-1H-pyrazole-5-carboxylic acid is its role in developing kinase inhibitors. Kinases are enzymes that play crucial roles in cell signaling pathways, and their dysregulation is associated with various diseases, including cancer. By targeting specific kinases, small-molecule inhibitors can modulate these pathways and restore normal cellular function. The pyrazole core has been shown to bind effectively to ATP pockets in kinase active sites, making it an ideal platform for drug design. The presence of both a 4-bromophenyl group and a carboxylic acid moiety allows for precise tuning of binding interactions, enhancing selectivity and potency.

Recent studies have highlighted the potential of 3-(4-bromophenyl)-1H-pyrazole-5-carboxylic acid in addressing neurological disorders. The compound’s ability to cross the blood-brain barrier has been explored in models of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Researchers have synthesized derivatives of this compound that exhibit neuroprotective effects by modulating neurotransmitter release and reducing oxidative stress. The versatility of the pyrazole scaffold allows for further modifications that can fine-tune its pharmacokinetic properties, making it an attractive candidate for future clinical trials.

The synthesis and application of 3-(4-bromophenyl)-1H-pyrazole-5-carboxylic acid also intersect with materials science, particularly in the development of organic electronic materials. Pyrazole derivatives have been used in organic light-emitting diodes (OLEDs) and photovoltaic cells due to their electron-donating properties and ability to form stable radicals. The bromine substituent enhances reactivity in polymerization reactions, allowing for the creation of conjugated polymers with tunable optoelectronic properties.

In conclusion, 3-(4-bromophenyl)-1H-pyrazole-5-carboxylic acid (CAS No. 46413-66-5) is a multifaceted compound with significant potential in pharmaceuticals, materials science, and beyond. Its unique structural features—combining a pyrazole core with a 4-bromophenyl substituent and a carboxylic acid group—make it a versatile scaffold for drug discovery and material innovation. As research continues to uncover new applications for this compound, its importance in advancing scientific knowledge and technological development is likely to grow.

• 164295-94-7(3-(2-naphthyl)-1{H}-pyrazole-5-carboxylic acid)
• 46413-67-6(3-(4-methylphenyl)-1H-pyrazole-5-carboxylic acid)
• 1135821-47-4(3-(3-bromophenyl)-1{H}-pyrazole-5-carboxylic acid)
• 78842-74-7(Methyl 3-(4-bromophenyl)-1H-pyrazole-5-carboxylate)
• 1037816-85-5(3-biphenyl-4-yl-1{H}-pyrazole-5-carboxylic acid)
• 890591-20-5(1H-Pyrazole-5-carboxylicacid, 3-(4-bromophenyl)-)
• 1134-49-2(5-phenyl-1h-pyrazole-3-carboxylic acid)
• 890007-12-2(3-(4-methylphenyl)-1H-pyrazole-5-carboxylic Acid)
• 948292-48-6(ETHYL 3-(4-BROMOPHENYL)-1H-PYRAZOLE-5-CARBOXYLATE)
• 5071-61-4(3-Phenyl-1H-pyrazole-5-carboxylic acid)