• 1. Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence
  Alexander V. Aksenov,Dmitrii A. Aksenov,Nicolai A. Aksenov,Anton A. Skomorokhov,Elena V. Aleksandrova,Michael Rubin RSC Adv. 2021 11 1783
• 2. Combinatorial organic materials research (COMR): design, synthesis and screening of a 225-membered materials library of liquid crystalline fluorinated p-quaterphenyls
  Oliver Deeg,Peter B?uerle Org. Biomol. Chem. 2003 1 1609
• 3. Control of excimer phosphorescence by steric effects in cyclometalated platinum(ii) diketonate complexes bearing peripheral carbazole moieties towards application in non-doped white OLEDs
  Naoki Okamura,Kazuaki Egawa,Takeshi Maeda,Shigeyuki Yagi New J. Chem. 2018 42 11583
• 4. High triplet energy exciplex hosts for deep blue phosphorescent organic light-emitting diodes
  Wook Song,Ha Lim Lee,Jun Yeob Lee J. Mater. Chem. C 2017 5 5923
• 5. ortho-Lithiation driven one-pot synthesis of quinazolines via [2 + 2 + 2] cascade annulation of halofluorobenzenes with nitriles
  Jen-Chun Hsueh,Fu-En Szu,Yin-Yin Yu,Man-kit Leung Org. Biomol. Chem. 2023 21 5297

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Fluorobenzenes
• Solvents and Organic Chemicals Organic Compounds Organic Halides

Chemical Profile of 1-Bromo-3,5-difluorobenzene (CAS No. 461-96-1)

1-Bromo-3,5-difluorobenzene, with the chemical formula C?H?BrF?, is a fluorinated aromatic brominated compound that has garnered significant attention in the field of pharmaceutical and agrochemical research. This compound serves as a versatile intermediate in the synthesis of various bioactive molecules, particularly in the development of novel therapeutic agents. Its unique structural features, including the presence of both bromine and fluorine substituents, make it a valuable building block for further functionalization and derivatization.

The CAS no. 461-96-1 identifier firmly establishes this compound within the chemical registry, ensuring consistent referencing across scientific literature and industrial applications. As a halogenated aromatic compound, 1-bromo-3,5-difluorobenzene exhibits distinct electronic and steric properties that influence its reactivity and utility in synthetic chemistry. The bromine atom introduces a strong electron-withdrawing effect, while the two fluorine atoms at the 3 and 5 positions enhance lipophilicity and metabolic stability, which are critical factors in drug design.

In recent years, the pharmaceutical industry has shown increasing interest in fluorinated aromatic compounds due to their potential to improve drug efficacy and pharmacokinetic profiles. 1-Bromo-3,5-difluorobenzene has been employed in the synthesis of various small-molecule inhibitors targeting key biological pathways involved in diseases such as cancer, inflammation, and infectious disorders. For instance, studies have demonstrated its utility in generating substituted benzamides and benzothiazoles that exhibit potent inhibitory activity against specific enzymes.

One notable application of 1-bromo-3,5-difluorobenzene is in the development of kinase inhibitors, which are crucial for treating cancers and inflammatory diseases. Researchers have leveraged its reactive bromine moiety to introduce further functional groups through cross-coupling reactions such as Suzuki-Miyaura or Buchwald-Hartwig couplings. These transformations allow for the construction of complex molecular architectures with high precision, enabling the optimization of binding affinity and selectivity.

Moreover, the fluorine atoms in 1-bromo-3,5-difluorobenzene contribute to its stability under physiological conditions, reducing susceptibility to metabolic degradation. This characteristic is particularly advantageous in drug development, where prolonged half-life can enhance therapeutic outcomes. Recent advancements in computational chemistry have also facilitated the rational design of derivatives based on this scaffold by predicting binding interactions with biological targets.

The agrochemical sector has not been left behind in exploring the potential of 1-bromo-3,5-difluorobenzene. Its incorporation into pesticide formulations has led to the development of novel compounds with improved efficacy against resistant pests while maintaining environmental safety. The halogenated aromatic structure provides enhanced bioavailability and target specificity, making it a promising candidate for next-generation crop protection agents.

In conclusion, 1-bromo-3,5-difluorobenzene (CAS no. 461-96-1) represents a cornerstone intermediate in modern synthetic chemistry with far-reaching implications across pharmaceuticals and agrochemicals. Its unique structural attributes enable diverse chemical modifications, fostering innovation in drug discovery and agricultural science. As research continues to uncover new applications for this compound, its significance is expected to grow further within the scientific community.

• 64248-56-2(2-Bromo-1,3-difluorobenzene)
• 13772-59-3(3-Bromo-1-fluoronaphthalene)
• 399-94-0(2-Bromo-1,4-difluorobenzene)
• 1073-06-9(1-Bromo-3-fluorobenzene)
• 1435-51-4(1,3-Dibromo-5-fluorobenzene)
• 2367-76-2(2-bromo-1,3,5-trifluoro-benzene)
• 327-51-5(1,4-Dibromo-2,5-difluorobenzene)
• 460-00-4(1-Bromo-4-fluorobenzene)
• 348-57-2(1-Bromo-2,4-difluorobenzene)
• 348-61-8(4-Bromo-1,2-difluorobenzene)