Cas no 458-35-5 (Coniferyl alcohol)
Coniferyl alcohol Chemical and Physical Properties
Names and Identifiers
-
- Coniferyl alcohol
- 4-(3-Hydroxyprop-1-en-1-yl)-2-methoxyphenol
- 4-(3-HYDROXYPROP-1-ENYL)-2-METHOXYPHENOL
- CONIFERYL ALCOHOL(RG)
- 4-Hydroxy-3-methoxycinnamyl alcohol
- Coniferol
- Coniferylalcohol
- gamma-Hydroxyisoeugenol
- trans-Coniferyl alcohol
- (E)-Coniferyl alcohol
- 4-(3-Hydroxy-1-propenyl)-2-methoxyphenol
- 4-[(1E)-3-hydroxyprop-1-en-1-yl]-2-methoxyphenol
- 3-(4-Hydroxy-3-methoxyphenyl)-2-propen-1-ol
- 4-Hydroxy-3-methoxycinnamic alcohol
- Coniferylic alcohol
- E-Coniferyl alcohol
- 4-[(1E)-3-Hydroxy-1-propenyl]-2-me
- 2-PROPEN-1-OL, 3-(4-HYDROXY-3-METHOXYPHENYL)-, (E)-
- A826901
- Phenol, 4-(3-hydroxy-1-propenyl)-2-methoxy-, (E)-
- 4-[3-Hydroxy-1-propenyl]-2-methoxyphenol
- (E) 3-(4-hydroxy-3-methoxyphenyl)-2-Propen-1-ol
- epsilon-coniferyl alcohol
- 32811-40-8
- SCHEMBL177683
- DTXSID50186489
- 4-hydroxy-3-methoxy cinnamyl alcohol
- AI3-36149
- CS-0032634
- AKOS005258118
- (e)-coniferol
- DTXCID7040447
- Coniferyl Alcohol1512
- Coniferyl?alcohol
- 4-((1E)-3-HYDROXY-1-PROPEN-1-YL)-2-METHOXYPHENOL
- Q418993
- E7SM92591P
- S6429
- trans-coniferol
- Coniferyl alcohol [MI]
- (E)-4-(3 -hydroxyprop-1-enyl)-2-methoxyphenol
- AC-34753
- Phenol, 4-(3-hydroxy-1-propenyl)-2-methoxy-
- 4-[(E)-3-hydroxyprop-1-enyl]-2-methoxy-phenol
- Coniferyl alcohol, E-
- 4-((1E)-3-hydroxyprop-1-en-1-yl)-2-methoxyphenol
- 3-(4-Hydroxy-3-methoxyphenyl)allyl alcohol
- 4-Hydroxy-3-methoxycinnamylic alcohol
- p-Hydroxy-m-methoxycinnamyl alcohol
- Epitope ID:116871
- 4-[(1E)-3-Hydroxy-1-propenyl]-2-methoxyphenol
- (E)-4-(3-Hydroxyprop-1-en-1-yl)-2-methoxyphenol
- Phenol, 4-(3-hydroxy-1-propen-1-yl)-2-methoxy-
- HY-N4283
- CONIFERYL-ALCOHOL
- 4-((1E)-3-Hydroxy-1-propenyl)-2-methoxyphenol
- JMFRWRFFLBVWSI-UHFFFAOYSA-N
- 458-35-5
- UNII-E7SM92591P
- EINECS 207-277-9
- 2-Propen-1-ol, 3-(4-hydroxy-3-methoxyphenyl), (E)-
- 4e70
- NS00031560
- Coniferyl Alcohol Phenolic
- EN300-6472482
- bmse010248
- 4-(3-hydroxy-1-propenyl)-2-methoxy-Phenol
- bmse000602
- 2-Propen-1-ol, 3-(4-hydroxy-3-methoxyphenyl)-
- F8420572-6986-4EF3-917B-3298FD384F2C
- D93191
- (E)-4-(3-hydroxyprop-1-enyl)-2-methoxyphenol
- bmse010285
- PHENOL, 4-((1E)-3-HYDROXY-1-PROPENYL)-2-METHOXY-
- 4-[(E)-3-hydroxyprop-1-enyl]-2-methoxyphenol
- EN300-1857771
- DTXSID9060029
- .gamma.-Hydroxyisoeugenol
- CHEMBL501870
- MFCD00002922
- Coniferyl alcohol, 98%
- PS-4366
- C00590
- 4-(3-Hydroxy-1-propen-1-yl)-2-methoxyphenol
- CHEBI:17745
- 69056-21-9
- 4-[(Z)-3-hydroxyprop-1-enyl]-2-methoxy-phenol
- Coniferyl alcohol, (Z)-
- cis-coniferyl alcohol
- 4-[(Z)-3-hydroxyprop-1-enyl]-2-methoxyphenol
- ASW5FSM5Z0
- 4-((1Z)-3-Hydroxy-1-propen-1-yl)-2-methoxyphenol
- Coniferyl alcohol, cis
- JMFRWRFFLBVWSI-IHWYPQMZSA-N
- AKOS025401152
- bmse010156
- (Z)-Coniferyl Alcohol
- Phenol, 4-(3-hydroxy-1-propenyl)-2-methoxy-, (Z)-
- CHEMBL2088631
- AC1LU7QP
- UNII-ASW5FSM5Z0
- Phenol, 4-((1Z)-3-hydroxy-1-propen-1-yl)-2-methoxy-
- 4-(3-Hydroxyprop-1-en-1yl)-2-methoxyphenol
- 3-(4-hydroxy-3-methoxyphenyl)-prop-2-enol
- Oprea1_201369
- AKOS028108458
- FT-0624038
- HBA81140
- FC69901
- 207-277-9
- HY-N4283A
- DB-342518
-
- MDL： MFCD00002922
- Inchi： 1S/C10H12O3/c1-13-10-7-8(3-2-6-11)4-5-9(10)12/h2-5,7,11-12H,6H2,1H3/b3-2+
- InChI Key： JMFRWRFFLBVWSI-NSCUHMNNSA-N
- SMILES： O(C)C1=C(C=CC(/C=C/CO)=C1)O
- BRN： 2048961
Computed Properties
- Exact Mass: 180.07900
- Monoisotopic Mass: 180.079
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 13
- Rotatable Bond Count: 3
- Complexity: 168
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 1
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: 3
- XLogP3: 1.4
- Topological Polar Surface Area: 49.7
- Molecular Weight: 180.20
Experimental Properties
- Color/Form: Not determined
- Density: 1.1272 (rough estimate)
- Melting Point: 75-80?°C (lit.)
- Boiling Point: 163-165?°C/3?mmHg(lit.)
- Flash Point: 163-165°C/3mm
- Refractive Index: 1.5080 (estimate)
- Solubility: alcohol: moderately soluble(lit.)
- PSA: 49.69000
- LogP: 1.40630
- Solubility: Not determined
- Merck: 14,2504
- Sensitiveness: Light Sensitive
Coniferyl alcohol Security Information
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Safety Instruction： S24/25
- FLUKA BRAND F CODES：4.8-8-10-23
- RTECS：SL5367000
- TSCA：Yes
- Storage Condition：?20°C
Coniferyl alcohol Customs Data
- HS CODE：2909500000
- Customs Data：
China Customs Code:
2909500000Overview:
2909500000. Ether phenol\Ether alcohol phenol and its halogenation\sulfonation\Nitrosative or nitrosative derivatives. VAT:17.0%. Tax refund rate:9.0%. Regulatory conditions:nothing. MFN tariff:5.5%. general tariff:30.0%
Declaration elements:
Product Name, component content, use to
Summary:
2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
Coniferyl alcohol Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| S e l l e c k ZHONG GUO | S6429-5mg |
Coniferyl alcohol |
458-35-5 | 98.40% | 5mg |
￥1122.15 | 2023-09-15 | |
| Alichem | A019145313-1g |
4-(3-Hydroxyprop-1-en-1-yl)-2-methoxyphenol |
458-35-5 | 95% | 1g |
$586.36 | 2023-09-01 | |
| SHANG HAI YUAN YE Biotechnology Co., Ltd. | B25651-20mg |
Coniferyl Alcohol |
458-35-5 | ,HPLC≥98% | 20mg |
￥1000.00 | 2021-09-02 | |
| ChemScence | CS-0032634-5mg |
Coniferyl alcohol |
458-35-5 | ≥98.0% | 5mg |
$50.0 | 2022-04-27 | |
| ChemScence | CS-0032634-10mg |
Coniferyl alcohol |
458-35-5 | ≥98.0% | 10mg |
$80.0 | 2022-04-27 | |
| ChemScence | CS-0032634-20mg |
Coniferyl alcohol |
458-35-5 | ≥98.0% | 20mg |
$140.0 | 2022-04-27 | |
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | 223735-100MG |
Coniferyl alcohol |
458-35-5 | 100mg |
￥1705.14 | 2023-12-09 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | 223735-1G |
Coniferyl alcohol |
458-35-5 | 1g |
￥3908.12 | 2023-12-09 | ||
| TRC | H533330-10mg |
4-(3-Hydroxyprop-1-en-1yl)-2-methoxyphenol |
458-35-5 | 10mg |
$ 58.00 | 2023-09-07 | ||
| TRC | H533330-50mg |
4-(3-Hydroxyprop-1-en-1yl)-2-methoxyphenol |
458-35-5 | 50mg |
$ 88.00 | 2023-09-07 |
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Coniferyl alcohol Related Literature
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Mukesh Gangar,Avinash Ittuveetil,Sandeep Goyal,Anang Pal,Harikrishnan M.,Vipin A. Nair RSC Adv. 2016 6 102116
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Mukesh Gangar,Avinash Ittuveetil,Sandeep Goyal,Anang Pal,Harikrishnan M.,Vipin A. Nair RSC Adv. 2016 6 102116
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Lionel Tarrago,Camille Modolo,Mehdi Yemloul,Viviane Robert,Pierre Rousselot-Pailley,Thierry Tron New J. Chem. 2018 42 11770
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N. D. N. Rodrigues,M. Staniforth,J. D. Young,Y. Peperstraete,N. C. Cole-Filipiak,J. R. Gord,P. S. Walsh,D. M. Hewett,T. S. Zwier,V. G. Stavros Faraday Discuss. 2016 194 709
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Vallabh S. Prabhudesai,K. Saravanakumar,Lakshmiprasad Gurrala,R. Vinu Sustainable Energy Fuels 2023 7 2117
Additional information on Coniferyl alcohol
Coniferyl Alcohol (CAS No. 458-35-5): Chemical Profile and Recent Research Applications
Coniferyl alcohol, chemically known as 4-hydroxy-3-methoxybenzyl alcohol, is a naturally occurring phenolic compound with the molecular formula C?H??O?. Its CAS number, 458-35-5, uniquely identifies it in the chemical and pharmaceutical industries. This compound is widely recognized for its role in plant secondary metabolism and has garnered significant attention due to its diverse biological activities and potential applications in pharmaceuticals, cosmetics, and industrial processes.
The structural framework of Coniferyl alcohol consists of a benzene ring substituted with a hydroxyl group at the 4-position and a methoxy group at the 3-position, with an alcohol functional group attached to the benzylic position. This unique configuration imparts remarkable chemical reactivity, making it a valuable intermediate in organic synthesis. The compound is primarily derived from the lignin fraction of plant cell walls, where it serves as a precursor to more complex polyphenolic structures such as lignans and tannins.
Recent advancements in natural product chemistry have highlighted the significance of Coniferyl alcohol in drug discovery. Its phenolic moiety enables hydrogen bonding interactions with biological targets, while its lipophilic benzylic alcohol group enhances membrane permeability, making it an attractive scaffold for medicinal chemists. Studies have demonstrated its potential in modulating enzyme activities, particularly those involving oxidative stress and inflammation pathways.
In the realm of pharmaceutical research, Coniferyl alcohol has been investigated for its anti-inflammatory and antioxidant properties. Preclinical studies suggest that it may inhibit the production of pro-inflammatory cytokines such as TNF-α and IL-6 by modulating nuclear factor kappa B (NF-κB) signaling. Additionally, its ability to scavenge reactive oxygen species has led researchers to explore its role in neuroprotective therapies. Emerging evidence indicates that Coniferyl alcohol may mitigate oxidative damage in neuronal cells, offering a promising candidate for treating neurodegenerative disorders like Alzheimer's disease.
Beyond medicine, Coniferyl alcohol finds utility in the cosmetic industry due to its skin-nourishing properties. Its antioxidant activity helps combat free radical-induced aging by protecting collagen fibers and elastin networks. Furthermore, its mild irritant profile makes it suitable for formulations targeting sensitive skin types. Cosmetic brands are increasingly incorporating derivatives of Coniferyl alcohol into anti-aging creams and serums to enhance their efficacy.
The industrial applications of Coniferyl alcohol are equally noteworthy. As a renewable resource derived from biomass, it serves as a green solvent and intermediate in biorefinery processes. Researchers are exploring its use in synthesizing biodegradable polymers and lubricants, aligning with global sustainability goals. Its compatibility with enzymatic catalysis also opens avenues for green chemistry initiatives, reducing reliance on traditional synthetic methods that often involve harsh reagents.
Current research trends are focusing on optimizing the extraction and purification methods of Coniferyl alcohol from natural sources to improve yield and cost-effectiveness. Advances in plant biotechnology have enabled genetic engineering approaches to enhance the accumulation of this compound in host organisms such as yeast or algae. Such innovations are expected to lower production costs and make Coniferyl alcohol more accessible for large-scale applications.
The pharmacokinetic profile of Coniferyl alcohol is another area of active investigation. Studies using computational modeling have predicted its absorption, distribution, metabolism, and excretion (ADME) properties, providing insights into optimal dosing regimens. Initial clinical trials have shown favorable bioavailability when administered orally or topically, suggesting its potential for therapeutic use without significant side effects.
Future directions in Coniferyl alcohol research include exploring its synergistic effects when combined with other bioactive compounds. Polypharmacological approaches leveraging multiple targets simultaneously may enhance therapeutic outcomes while minimizing resistance development. Additionally, nanotechnology-based delivery systems are being developed to improve the stability and targeted release of Coniferyl alcohol, further expanding its medical applications.
In conclusion, Coniferyl alcohol (CAS No. 458-35-5) is a multifaceted compound with broad utility across pharmaceuticals, cosmetics, and industry sectors. Its natural origin coupled with remarkable biological activities positions it as a key player in modern chemistry research. As scientific understanding deepens and innovative technologies emerge, the potential applications of this versatile compound will continue to expand, reinforcing its importance in addressing global challenges.
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