• 1. pH-stable hyperbranched poly(ethyleneimine)-maltose films for the interaction with phosphate containing drugs
  Anne Richter,Andreas Janke,Stefan Zschoche,Ralf Zimmermann,Frank Simon,Klaus-Jochen Eichhorn,Brigitte Voit,Dietmar Appelhans New J. Chem. 2010 34 2105
• 2. Design, synthesis and crystal structure determination of dinuclear copper-based potential chemotherapeutic drug entities; in vitro DNA binding, cleavage studies and an evaluation of genotoxicity by micronucleus test and comet assay
  Farukh Arjmand,Mohd Muddassir,Yusra Zaidi,Debashis Ray Med. Chem. Commun. 2013 4 394
• 3. The 2-phenylbenzimidazole-5-sulfonate/layered double hydroxide co-intercalation composite and its luminescence response to nucleotides
  Shufang Zheng,Jun Lu,Wu Li,Yumei Qin,Dongpeng Yan,David G. Evans,Xue Duan J. Mater. Chem. C 2014 2 5161
• 4. Multiple switchable circularly polarized luminescence from nucleotide/terbium(iii) complexes
  Chujing Yang,Zhiwei Zhang,Jingqi Chen,Xinying Zhang,Yankai Dai,Xuyi Li,Yingying Chen,Jiaqiang Xu,Lingyan Feng New J. Chem. 2023 47 4472
• 5. Synthesis of barbituric acid containing nucleotides and their implications for the origin of primitive informational polymers
  Chaitanya V. Mungi,Sachin Kumar Singh,Jeetender Chugh,Sudha Rajamani Phys. Chem. Chem. Phys. 2016 18 20144

• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides Purine ribonucleoside monophosphates
• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides Purine ribonucleotides Purine ribonucleoside monophosphates
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Adenosine 5’-Monophosphate Disodium Salt Hydrate (CAS No. 4578-31-8): A Comprehensive Overview

Adenosine 5’-Monophosphate Disodium Salt Hydrate, with the chemical formula C₁₀H₁₁N₅O₉Na₂.H₂O, is a significant compound in the field of biochemistry and pharmacology. Its CAS number, CAS No. 4578-31-8, uniquely identifies it in scientific literature and industrial applications. This compound is widely recognized for its role in cellular energy metabolism and its potential therapeutic applications.

The molecular structure of Adenosine 5’-Monophosphate Disodium Salt Hydrate consists of an adenosine moiety linked to a monophosphate group, with the addition of two sodium ions and a water molecule in its hydrated form. This configuration enhances its solubility and stability, making it a preferred choice for various biochemical assays and pharmaceutical formulations.

In recent years, research on Adenosine 5’-Monophosphate Disodium Salt Hydrate has gained significant traction due to its multifaceted biological activities. One of the most notable areas of study is its role in modulating cellular signaling pathways. Adenosine monophosphate (AMP) is a key intermediate in the synthesis of adenosine triphosphate (ATP), the primary energy currency of cells. By influencing AMP levels, this compound can affect various metabolic processes, including glucose uptake and lipid metabolism.

Recent studies have highlighted the potential of Adenosine 5’-Monophosphate Disodium Salt Hydrate in the management of metabolic disorders such as obesity and type 2 diabetes. Research indicates that by enhancing AMPK (adenosine monophosphate-activated protein kinase) activity, this compound can promote glucose utilization and fatty acid oxidation, thereby improving insulin sensitivity. These findings have opened new avenues for the development of novel therapeutic strategies targeting metabolic syndromes.

The pharmacological properties of Adenosine 5’-Monophosphate Disodium Salt Hydrate have also been explored in the context of cardiovascular health. Studies suggest that this compound can exert protective effects against ischemia-reperfusion injury in the heart. By activating adenosine receptors, it can reduce inflammation and oxidative stress, thereby mitigating tissue damage during cardiac events. This has led to investigations into its potential use as a cardioprotective agent in clinical settings.

In addition to its metabolic and cardiovascular benefits, Adenosine 5’-Monophosphate Disodium Salt Hydrate has shown promise in neuroprotective applications. Emerging research indicates that it can cross the blood-brain barrier and exert neuroprotective effects against neurodegenerative diseases such as Alzheimer's and Parkinson's. By modulating neurotransmitter release and reducing neuroinflammation, this compound may help preserve neuronal function and delay disease progression.

The synthesis and purification of Adenosine 5’-Monophosphate Disodium Salt Hydrate are critical for ensuring its efficacy in various applications. Advanced synthetic methodologies have been developed to produce high-purity batches of this compound, meeting the stringent requirements of pharmaceutical manufacturers. Techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry are employed to verify the chemical integrity and purity of the final product.

The industrial significance of CAS No. 4578-31-8, corresponding to Adenosine 5’-Monophosphate Disodium Salt Hydrate, cannot be overstated. It serves as a vital intermediate in the production of various biochemical reagents and pharmaceuticals. Its versatility in biological assays makes it an indispensable tool for researchers studying cellular processes, enzyme kinetics, and drug interactions.

The future prospects for Adenosine 5’-Monophosphate Disodium Salt Hydrate are promising, with ongoing research aimed at uncovering new therapeutic applications and optimizing its delivery systems. Innovations in nanotechnology have enabled the development of targeted delivery formulations that enhance bioavailability and therapeutic efficacy. These advancements hold great potential for transforming how metabolic disorders, cardiovascular diseases, and neurodegenerative conditions are managed.

In conclusion, Adenosine 5’-Monophosphate Disodium Salt Hydrate, identified by its CAS number CAS No. 4578-31-8, is a multifaceted compound with significant implications in biochemistry and pharmacology. Its role in cellular energy metabolism, modulation of signaling pathways, and potential therapeutic applications make it a cornerstone in modern medical research. As scientific understanding continues to evolve, the applications of this compound are expected to expand, offering new hope for patients suffering from various chronic diseases.

• 4958-39-8(Adenosine-3'-monophosphate Sodium Salt)
• 61240-14-0(3'-Adenylic acid, monosodium salt (9CI))
• 88467-42-9(5'-Adenylic acid, monopentyl ester (9CI))
• 75431-54-8(Adenosine 3',5'-Diphosphate Disodium Salt)
• 88467-43-0(5'-Adenylic acid, monohexyl ester (9CI))
• 88467-41-8(5'-Adenylic acid, monobutyl ester)
• 132-00-3(5'-Adenylic acid, monosodium salt)
• 13474-03-8(Adenosine Phosphate Disodium)
• 149022-20-8(Adenosine 5'-Monophosphate (Sodium Salt Hydrate))
• 88480-66-4(5'-Adenylic acid, monoheptyl ester)