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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzoxazoles Benzoxazoles
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzoxazoles

Recent Advances in the Study of 1,3-Benzoxazol-2-amine (CAS: 4570-41-6) and Its Applications in Chemical Biology and Medicine

1,3-Benzoxazol-2-amine (CAS: 4570-41-6) is a heterocyclic compound that has garnered significant attention in the field of chemical biology and medicinal chemistry due to its versatile pharmacological properties. Recent studies have explored its potential as a scaffold for drug development, particularly in the areas of antimicrobial, anticancer, and anti-inflammatory therapies. This research brief synthesizes the latest findings on this compound, highlighting its molecular mechanisms, synthetic pathways, and therapeutic applications.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated that 1,3-benzoxazol-2-amine derivatives exhibit potent inhibitory effects against bacterial pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). The researchers utilized a structure-activity relationship (SAR) approach to optimize the compound's efficacy, leading to the identification of several analogs with enhanced antibacterial activity. These findings underscore the potential of 1,3-benzoxazol-2-amine as a lead compound for developing novel antibiotics.

In the realm of oncology, a recent preprint on bioRxiv revealed that 1,3-benzoxazol-2-amine derivatives can selectively target cancer cells by modulating key signaling pathways, such as the PI3K/AKT/mTOR axis. The study employed high-throughput screening and molecular docking simulations to identify the most promising candidates, which showed significant cytotoxicity against breast and lung cancer cell lines. These results suggest that further preclinical studies are warranted to evaluate the compound's potential as an anticancer agent.

Another area of interest is the compound's anti-inflammatory properties. A 2024 paper in European Journal of Pharmacology reported that 1,3-benzoxazol-2-amine derivatives effectively suppress the production of pro-inflammatory cytokines, such as TNF-α and IL-6, in murine models of rheumatoid arthritis. The study highlighted the compound's ability to inhibit NF-κB signaling, a critical pathway in inflammation, thereby offering a promising avenue for developing new anti-inflammatory drugs.

From a synthetic chemistry perspective, recent advancements have focused on improving the yield and scalability of 1,3-benzoxazol-2-amine production. A 2023 study in Organic Process Research & Development introduced a novel catalytic system that significantly reduces reaction times and byproduct formation. This innovation could facilitate the large-scale synthesis of the compound, making it more accessible for further research and development.

In conclusion, 1,3-benzoxazol-2-amine (CAS: 4570-41-6) represents a multifaceted compound with broad applications in chemical biology and medicine. Its antimicrobial, anticancer, and anti-inflammatory properties, coupled with advancements in synthetic methodologies, position it as a valuable candidate for future drug discovery efforts. Ongoing research is expected to uncover additional therapeutic potentials and optimize its pharmacological profile for clinical translation.

• 24160-33-6(Zoxazolamine-d2)
• 188063-14-1(6-methyl-1,3-benzoxazol-2-amine)
• 64037-15-6(5-methyl-1,3-benzoxazol-2-amine)
• 12773-89-6(Magnesium alloy, base, Mg 96-97,Nd 2.5-3.5,Zr 0.3-0.9 (MA12))
• 15062-88-1(2-Hydrazino-1,3-benzoxazole)
• 13858-89-4(N,N-Dimethylbenzoxazole-2-amine)
• 64037-26-9(2,5-Diaminobenzoxazol)
• 1682-39-9(5-fluorobenzo[d]oxazol-2-amine)
• 19776-98-8(N-methyl-1,3-benzoxazol-2-amine)
• 64037-13-4(2-Benzoxazolamine,5-iodo-)