• 1. An alkynylboronatecycloaddition strategy to functionalised benzyne derivatives?
  James D. Kirkham,Patrick M. Delaney,George J. Ellames,Eleanor C. Row,Joseph P. A. Harrity Chem. Commun., 2010,46, 5154-5156
• 2. An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes?
  H. V. Jain,D. Verthelyi,S. L. Beaucage RSC Adv., 2017,7, 42519-42528
• 3. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
  Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
• 4. An apparatus for testing water by measurement of its electrical conductivity
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• 5. An investigation into the origin of variations in photovoltaic performance using D–D–π–A and D–A–π–A triphenylimidazole dyes with a copper electrolyte?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Hydroxybenzoic acid derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Hydroxybenzoic acid derivatives

3-Hydroxy-2-(trifluoromethyl)benzoic Acid (CAS 4563-94-4): Properties, Applications, and Market Insights

3-Hydroxy-2-(trifluoromethyl)benzoic acid (CAS 4563-94-4) is a fluorinated aromatic carboxylic acid derivative with significant industrial and research applications. This compound, often referred to as 3-hydroxy-2-TFMBA, combines the reactivity of a benzoic acid scaffold with the unique properties imparted by the trifluoromethyl and hydroxyl functional groups. Its molecular formula is C₈H₅F₃O₃, and it exhibits a molecular weight of 206.12 g/mol.

The presence of both hydroxy and carboxylic acid groups makes this compound a versatile intermediate in organic synthesis. Researchers frequently utilize 3-hydroxy-2-(trifluoromethyl)benzoic acid as a building block for pharmaceuticals, agrochemicals, and advanced materials. The trifluoromethyl group enhances the compound's lipophilicity and metabolic stability, making it particularly valuable in drug discovery programs targeting improved bioavailability.

Recent advancements in fluorinated compound synthesis have driven increased interest in CAS 4563-94-4. The pharmaceutical industry particularly values this chemical for developing novel anti-inflammatory agents and antimicrobial compounds. Its structural features allow for diverse modifications, enabling medicinal chemists to fine-tune drug candidates' properties. The compound's melting point typically ranges between 180-185°C, and it demonstrates good solubility in polar organic solvents like methanol and dimethyl sulfoxide (DMSO).

Environmental scientists have recently explored 3-hydroxy-2-TFMBA derivatives as potential green chemistry alternatives. The compound's unique electronic properties, conferred by the trifluoromethyl group, make it an interesting subject for studying electron-withdrawing effects in aromatic systems. Computational chemistry studies frequently employ this molecule as a model system for understanding substituent effects on aromatic ring reactivity.

The global market for 3-hydroxy-2-(trifluoromethyl)benzoic acid has shown steady growth, particularly in Asia-Pacific regions where pharmaceutical innovation is accelerating. Current production methods typically involve multi-step synthesis from commercially available precursors, with recent patents focusing on more sustainable catalytic processes. Analytical characterization typically employs HPLC, NMR spectroscopy, and mass spectrometry techniques to ensure high purity standards required for research and industrial applications.

Material science applications of CAS 4563-94-4 have gained attention in developing specialty polymers and liquid crystal materials. The compound's ability to form stable hydrogen bonds while maintaining thermal stability makes it valuable for creating advanced functional materials. Researchers are investigating its potential in designing self-assembling molecular systems and supramolecular architectures.

Safety considerations for handling 3-hydroxy-2-(trifluoromethyl)benzoic acid follow standard laboratory protocols for carboxylic acids. Proper personal protective equipment including gloves and eye protection is recommended when working with this compound. While not classified as highly hazardous, appropriate ventilation and containment measures should be implemented during large-scale operations.

The future outlook for 3-hydroxy-2-TFMBA appears promising, with increasing demand from both academic and industrial sectors. Ongoing research into more efficient synthetic routes and expanded applications continues to reveal new potential uses for this versatile compound. Its combination of aromaticity, fluorine chemistry, and bifunctional reactivity positions it as an important tool in modern chemical research and development.

Storage recommendations for 4563-94-4 suggest keeping the material in a cool, dry place away from strong oxidizing agents. The compound typically shows good stability under recommended storage conditions, with shelf lives exceeding two years when properly contained. Suppliers generally offer this chemical in various purity grades ranging from technical grade to high-purity (>98%) analytical standards.

Recent publications have highlighted innovative applications of 3-hydroxy-2-(trifluoromethyl)benzoic acid in catalysis and medicinal chemistry. The compound's structural features enable its use as a ligand in transition metal catalysis and as a precursor for bioactive molecule synthesis. These developments underscore the growing importance of fluorinated building blocks in contemporary chemical research.

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