Cas no 456-42-8 (1-(chloromethyl)-3-fluorobenzene)
1-(Chloromethyl)-3-fluorobenzene is a fluorinated aromatic compound featuring both chloromethyl and fluorine substituents on a benzene ring. This structure imparts reactivity at the chloromethyl group, making it a versatile intermediate in organic synthesis, particularly for nucleophilic substitution reactions. The presence of the fluorine atom enhances electron-withdrawing effects, influencing the compound's reactivity and stability. It is commonly employed in pharmaceutical and agrochemical manufacturing, where precise functionalization is required. The compound's well-defined reactivity profile and compatibility with various reaction conditions make it a valuable building block for constructing complex molecules. Proper handling is essential due to its lachrymatory properties and potential moisture sensitivity.
456-42-8 structure
Product Name:1-(chloromethyl)-3-fluorobenzene
CAS No:456-42-8
MF:C7H6ClF
MW:144.573944568634
MDL:MFCD00000904
CID:37530
PubChem ID:9974
Update Time:2025-06-06
1-(chloromethyl)-3-fluorobenzene Chemical and Physical Properties
Names and Identifiers
-
- 1-(Chloromethyl)-3-fluorobenzene
- alpha-Chloro-3-fluorotoluene
- 4-fluoro(chloromethyl)benzene
- m-Fluorobenzyl chloride
- alpha-Chloro-m-fluorotoluene
- 3-Fluorobenzyl chloride
- 1-(Chloromethyl)-3-fluoro-benzene
- 3-Fluorobenzylchloride
- Benzene, 1-(chloromethyl)-3-fluoro-
- fluorobenzyl-3 chloride
- 1-Chloromethyl-3-fluoro-benzene
- Toluene, .alpha.-chloro-m-fluoro-
- .alpha.-Chloro-m-fluorotoluene
- .alpha.-Chloro-3-fluorotoluene
- A-CHLORO-3-FLUOROTOLUENE
- 3-(chloromethyl)-1-fluorobenzene
- XBDXMDVEZLOGMC-UHFFFAOYSA-N
- 3-flurobenzylch
- Toluene, alpha-chloro-m-fluoro-
- 456-42-8
- -(chloromethyl)-3-fluoro-benzen;3-Fluorophenylmethyl chloride;Toluene, alpha-chloro-m-fluoro-
- SCHEMBL70652
- A22404
- FT-0615725
- AM81465
- EINECS 207-264-8
- MFCD00000904
- AC-26193
- NSC-60720
- NSC 60720
- F0210
- EN300-18208
- 3-flurobenzylchloride
- F2190-0252
- 3-Fluorobenzyl chloride, 96%
- 3-Fluorophenylmethyl chloride
- CS-D0813
- m-fluorobenzylchloride
- DTXSID4060026
- 3-flourobenzyl chloride
- m-fluoro-benzyl chloride
- 3-fluoro-benzyl chloride
- NSC60720
- DXT56E2KBP
- NS00126547
- W-106121
- AKOS000120643
- 1(Chloromethyl)3fluorobenzene
- Toluene, alphachloromfluoro (8CI)
- mFluorobenzyl chloride
- alphaChloromfluorotoluene
- DTXCID8040438
- m-Fluorobenzyl chloride; alpha-Chloro-m-fluorotoluene; 1-(Chloromethyl)-3-fluoro-benzene
- alphaChloro3fluorotoluene
- Benzene, 1(chloromethyl)3fluoro
- STL195659
- Toluene, alphachloromfluoro
- DB-024085
- 1-(chloromethyl)-3-fluorobenzene
-
- MDL： MFCD00000904
- Inchi： 1S/C7H6ClF/c8-5-6-2-1-3-7(9)4-6/h1-4H,5H2
- InChI Key： XBDXMDVEZLOGMC-UHFFFAOYSA-N
- SMILES： ClCC1C=CC=C(C=1)F
- BRN： 742265
Computed Properties
- Exact Mass: 144.01400
- Monoisotopic Mass: 144.014
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 1
- Heavy Atom Count: 9
- Rotatable Bond Count: 1
- Complexity: 85
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: 2.8
- Topological Polar Surface Area: 0
Experimental Properties
- Color/Form: Not determined
- Density: 1.194
- Boiling Point: 180°C(lit.)
- Flash Point: 58 oC
- Refractive Index: 1.5115-1.5135
- Solubility: 40g/l
- Water Partition Coefficient: 40 g/L (20 oC)
- PSA: 0.00000
- LogP: 2.56450
- Sensitiveness: Lachrymatory
- Solubility: 40 g/L (20 oC)
1-(chloromethyl)-3-fluorobenzene Security Information
-
Symbol:
- Prompt：dangerous
- Signal Word：Danger
- Hazard Statement： H226,H314
- Warning Statement： P280,P305+P351+P338,P310
- Hazardous Material transportation number：UN 2920 8/PG 2
- WGK Germany：3
- Hazard Category Code： R34
- Safety Instruction： S26-S36/37/39-S45
-
Hazardous Material Identification：
- HazardClass：8 (3)
- PackingGroup：II
- TSCA：Yes
- Storage Condition：Store at room temperature
- Safety Term：3
- Packing Group：III
- Risk Phrases：R34
- Packing Group：III
- Hazard Level：3
1-(chloromethyl)-3-fluorobenzene Customs Data
- HS CODE：29036990
- Customs Data：
China Customs Code:
2903999090Overview:
2903999090 Other aromatic halogenated derivatives. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:5.5% general tariff:30.0%
Declaration elements:
Product Name, component content, use to
Summary:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
1-(chloromethyl)-3-fluorobenzene Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | 001632-25g |
3-Fluorobenzyl chloride |
456-42-8 | 96% | 25g |
￡10.00 | 2022-03-01 | |
| Fluorochem | 001632-100g |
3-Fluorobenzyl chloride |
456-42-8 | 96% | 100g |
￡19.00 | 2022-03-01 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | F123352-100g |
1-(chloromethyl)-3-fluorobenzene |
456-42-8 | 97% | 100g |
￥134.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | F123352-25g |
1-(chloromethyl)-3-fluorobenzene |
456-42-8 | 97% | 25g |
￥116.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | F123352-500g |
1-(chloromethyl)-3-fluorobenzene |
456-42-8 | 97% | 500g |
￥487.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | F123352-5g |
1-(chloromethyl)-3-fluorobenzene |
456-42-8 | 97% | 5g |
￥29.90 | 2023-09-02 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R015460-100g |
1-(chloromethyl)-3-fluorobenzene |
456-42-8 | 97% | 100g |
￥124 | 2024-05-23 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R015460-25g |
1-(chloromethyl)-3-fluorobenzene |
456-42-8 | 97% | 25g |
￥53 | 2024-05-23 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R015460-5g |
1-(chloromethyl)-3-fluorobenzene |
456-42-8 | 97% | 5g |
￥25 | 2024-05-23 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R015460-500g |
1-(chloromethyl)-3-fluorobenzene |
456-42-8 | 97% | 500g |
￥447 | 2024-05-23 |
1-(chloromethyl)-3-fluorobenzene Suppliers
Shanghai Hongxiang Biomedical Technology Co., Ltd.
Gold Member
Audited Supplier
(CAS:456-42-8)3-Fluorobenzyl Chloride
Order Number:BR086
Stock Status:inquiry
Quantity:25kg
Purity:pure
Pricing Information Last Updated:Thursday, 23 October 2025 10:58
Price ($):inquiry
Email:[email protected]
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier
(CAS:456-42-8)3-Fluorobenzyl chloride
Order Number:sfd21100
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:38
Price ($):discuss personally
Email:[email protected]
Jiangsu Xinsu New Materials Co., Ltd
Gold Member
Audited Supplier
(CAS:456-42-8)
Order Number:SFD1134
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Wednesday, 11 December 2024 17:02
Price ($):
Email:[email protected]
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier
(CAS:456-42-8)間氟氯芐
Order Number:LE27065756
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 13:04
Price ($):discuss personally
Email:[email protected]
1-(chloromethyl)-3-fluorobenzene Related Literature
-
Sheng Zhang,Zhilong Xie,Zhanqiang Ye,Mingyang Zhang,Dongdeng Li,Masahiko Yamaguchi,Ming Bao Org. Biomol. Chem. 2022 20 6869
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