• 1. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 2. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 3. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
  Ghazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683
• 4. Distribution and ecological risk assessment of typical antibiotics in the surface waters of seven major rivers, China?
  Environ. Sci.: Processes Impacts, 2021,23, 1088-1100
• 5. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?
  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzenes Nitrophenyl ethers

Research Brief on 2-Fluoro-4-nitroanisole (CAS: 455-93-6) in Chemical and Biomedical Applications

2-Fluoro-4-nitroanisole (CAS: 455-93-6) is a fluorinated nitroaromatic compound that has garnered significant attention in recent years due to its versatile applications in chemical synthesis and biomedical research. This research brief consolidates the latest findings on this compound, focusing on its synthesis, reactivity, and potential therapeutic uses. The compound's unique chemical properties, such as its electron-withdrawing nitro and fluoro groups, make it a valuable intermediate in the development of pharmaceuticals and agrochemicals.

Recent studies have highlighted the role of 2-Fluoro-4-nitroanisole as a key precursor in the synthesis of novel heterocyclic compounds. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated its utility in the construction of fluorinated quinoline derivatives, which exhibit promising antimicrobial activity. The study employed a multi-step synthetic route, where 2-Fluoro-4-nitroanisole served as the starting material for nucleophilic aromatic substitution reactions, followed by cyclization to yield the target compounds.

In addition to its synthetic applications, 2-Fluoro-4-nitroanisole has been investigated for its potential in drug discovery. A 2024 preprint on bioRxiv reported its use as a scaffold for designing small-molecule inhibitors of protein kinases involved in cancer progression. The researchers utilized computational docking studies to predict binding affinities, followed by in vitro assays to validate the inhibitory effects. The results indicated that derivatives of 2-Fluoro-4-nitroanisole could selectively target specific kinase isoforms, offering a new avenue for anticancer drug development.

Another area of interest is the environmental impact and biodegradation of 2-Fluoro-4-nitroanisole. A study published in Environmental Science & Technology (2023) explored its degradation pathways in soil and water systems. The findings revealed that microbial consortia could metabolize the compound into less toxic intermediates, suggesting potential bioremediation strategies for nitroaromatic contaminants. This research underscores the importance of understanding the ecological fate of such compounds, especially in industrial settings where they are frequently used.

In conclusion, 2-Fluoro-4-nitroanisole (CAS: 455-93-6) continues to be a compound of significant interest in both chemical and biomedical research. Its applications range from synthetic chemistry to drug discovery and environmental science, highlighting its multifaceted utility. Future studies should focus on optimizing its synthetic routes, exploring new therapeutic targets, and assessing its long-term environmental effects to fully harness its potential.

• 454-16-0(1-fluoro-2-methoxy-4-nitro-benzene)
• 1478-03-1(Benzene, 1-fluoro-2-(4-nitrophenoxy)-)
• 175435-40-2(1-Fluoro-2,3-dimethoxy-5-nitrobenzene)
• 446-20-8(5-Fluoro-4-methoxy-2-nitroaniline)
• 221198-59-0(2-Fluoro-1-(2-methoxyethoxy)-4-nitrobenzene)
• 392-25-6(1,3-difluoro-2-methoxy-5-nitrobenzene)
• 28280-37-7(Benzene,2,4-difluoro-1-(4-nitrophenoxy)-)
• 647858-19-3(Ethanol, 2-(2-fluoro-4-nitrophenoxy)-)
• 83189-99-5(1-(difluoromethoxy)-2-fluoro-4-nitrobenzene)
• 827628-36-4(Benzene, 1,3-difluoro-2-(methoxymethoxy)-5-nitro-)