Cas no 4546-54-7 (2-aminopurine riboside)
2-aminopurine riboside Chemical and Physical Properties
Names and Identifiers
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- 2-aminopurine riboside
- 2-(2-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
- 2-Amino-9-beta-D-ribofuranosyl-9H-purine
- BDBM50335312
- 2-Amino purine riboside; 2-amino-9-(beta-D-ribo-furanosyl)-9H-purine
- AKOS027327924
- 4546-54-7
- OJI
- CHEMBL1651367
- 2-amino-9-beta-d-ribofuranosylpurine
- 2-NH2-Riboside
- (2R,3R,4S,5R)-2-(2-azanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
- SCHEMBL1494485
- 2-Amino-9-(b-D-ribofuranosyl)purine
- AS-47253
- (2R,3R,4S,5R)-2-(2-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
- (2R,3R,4S,5R)-2-(2-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
- F12889
- 2-Amino Riboside
- MFCD00037992
- (2R,3R,4S,5R)-2-(2-AMINOPURIN-9-YL)-5-(HYDROXYMETHYL)OXOLANE-3,4-DIOL
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- MDL： MFCD00037992
- Inchi： 1S/C10H13N5O4/c11-10-12-1-4-8(14-10)15(3-13-4)9-7(18)6(17)5(2-16)19-9/h1,3,5-7,9,16-18H,2H2,(H2,11,12,14)/t5-,6-,7-,9-/m1/s1
- InChI Key： JVOJULURLCZUDE-JXOAFFINSA-N
- SMILES： O1[C@H](CO)[C@H]([C@H]([C@@H]1N1C=NC2C=NC(N)=NC1=2)O)O
Computed Properties
- Exact Mass: 267.09700
- Monoisotopic Mass: 267.096754
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 4
- Hydrogen Bond Acceptor Count: 8
- Heavy Atom Count: 19
- Rotatable Bond Count: 2
- Complexity: 335
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 4
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: 3
- XLogP3: nothing
- Topological Polar Surface Area: 140
Experimental Properties
- Color/Form: Gray white crystalline solid
- Density: 2.08
- Melting Point: 105-115°C
- Boiling Point: 711.8 °C at 760 mmHg
- Flash Point: 384.3 °C
- Refractive Index: 1.907
- PSA: 139.54000
- LogP: -1.39880
- Vapor Pressure: 0.0±2.4 mmHg at 25°C
2-aminopurine riboside Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： H303+H313+H333
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
2-aminopurine riboside Customs Data
- HS CODE：2933599090
- Customs Data：
China Customs Code:
2933599090Overview:
2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
2-aminopurine riboside Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Alichem | A159003037-1g |
(2R,3R,4S,5R)-2-(2-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol |
4546-54-7 | 97% | 1g |
$610.20 | 2023-09-01 | |
| TRC | A628900-50mg |
2-Aminopurine Riboside |
4546-54-7 | 50mg |
$ 68.00 | 2023-04-19 | ||
| TRC | A628900-250mg |
2-Aminopurine Riboside |
4546-54-7 | 250mg |
$ 249.00 | 2023-04-19 | ||
| abcr | AB462871-250 mg |
2-Aminopurine riboside; . |
4546-54-7 | 250mg |
€430.90 | 2023-06-15 | ||
| abcr | AB462871-1 g |
2-Aminopurine riboside; . |
4546-54-7 | 1g |
€995.90 | 2023-06-15 | ||
| Chemenu | CM138668-1g |
(2R,3R,4S,5R)-2-(2-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol |
4546-54-7 | 97% | 1g |
$*** | 2023-05-30 | |
| A2B Chem LLC | AD25881-250mg |
2-Aminopurine riboside |
4546-54-7 | 95% | 250mg |
$259.00 | 2024-04-20 | |
| A2B Chem LLC | AD25881-1g |
2-Aminopurine riboside |
4546-54-7 | 95% | 1g |
$604.00 | 2024-04-20 | |
| eNovation Chemicals LLC | Y1001651-250mg |
2-aminopurine riboside |
4546-54-7 | 95% | 250mg |
$800 | 2024-08-02 | |
| SHENG KE LU SI SHENG WU JI SHU | sc-220703-25 mg |
2-Aminopurine Riboside, |
4546-54-7 | ≥98% | 25mg |
￥752.00 | 2023-07-11 |
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2-aminopurine riboside Related Literature
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Hendrik B?hnke,Katharina R?ttger,Rebecca A. Ingle,Hugo J. B. Marroux,Mats Bohnsack,Andrew J. Orr-Ewing,Friedrich Temps Phys. Chem. Chem. Phys. 2018 20 20033
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Jacek Wierzchowski,Jan M. Antosiewicz,David Shugar Mol. BioSyst. 2014 10 2756
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3. Acid–base equilibria in aqueous solutions of 2-aminopurine radical cations generated by two-photon photoionizationVladimir Shafirovich,Alexander Dourandin,Natalia P. Luneva,Nicholas E. Geacintov J. Chem. Soc. Perkin Trans. 2 2000 271
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4. Extraction of lifetime distributions from fluorescence decays with application to DNA-base analoguesAoife C. Fogarty,Anita C. Jones,Philip J. Camp Phys. Chem. Chem. Phys. 2011 13 3819
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Grégory Pieters,Alessandro Cazzolaro,Renato Bonomi,Leonard J. Prins Chem. Commun. 2012 48 1916
Additional information on 2-aminopurine riboside
2-Aminopurine Riboside: A Versatile Nucleoside Analog with Broad Applications
2-Aminopurine riboside (CAS No. 4546-54-7), also known as 2-AP riboside, is a modified nucleoside that has garnered significant attention in biochemical and pharmaceutical research. This compound, a derivative of the natural nucleoside adenosine, features an amino group at the 2-position of the purine ring, which imparts unique properties and functionalities. Researchers and industry professionals are increasingly interested in 2-aminopurine riboside due to its potential applications in molecular biology, drug development, and diagnostic assays.
The chemical structure of 2-aminopurine riboside consists of a purine base linked to a ribose sugar via a β-glycosidic bond. This structural modification enhances its fluorescence properties, making it a valuable tool for studying nucleic acid dynamics and protein-nucleic acid interactions. The CAS No. 4546-54-7 is a critical identifier for researchers sourcing this compound, ensuring accuracy and reproducibility in experiments. Recent advancements in nucleoside chemistry have further highlighted the importance of 2-AP riboside in developing novel therapeutic agents.
One of the most prominent applications of 2-aminopurine riboside is its use as a fluorescent probe in biophysical studies. Its ability to mimic natural nucleosides while providing detectable signals allows scientists to monitor real-time changes in DNA and RNA structures. This feature is particularly relevant in the context of gene editing technologies, such as CRISPR-Cas9, where understanding nucleic acid interactions is paramount. Additionally, 2-AP riboside has shown promise in the development of antiviral drugs, as it can interfere with viral replication mechanisms.
The market for modified nucleosides like 2-aminopurine riboside is expanding rapidly, driven by the growing demand for precision medicine and personalized therapeutics. Pharmaceutical companies are investing heavily in research to explore the potential of 2-AP riboside in treating diseases such as cancer and viral infections. Furthermore, the compound's role in epigenetic research has opened new avenues for understanding gene regulation and cellular processes. As a result, CAS No. 4546-54-7 has become a key reference for scientists and suppliers alike.
In the field of diagnostics, 2-aminopurine riboside is utilized in the development of sensitive and specific assays for detecting nucleic acid mutations. Its fluorescence properties enable high-throughput screening methods, which are essential for early disease detection and biomarker discovery. The compound's compatibility with various detection platforms, including qPCR and next-generation sequencing, makes it a versatile choice for researchers. With the rise of point-of-care testing, the demand for reliable nucleoside analogs like 2-AP riboside is expected to surge.
From a synthetic perspective, 2-aminopurine riboside can be produced through enzymatic or chemical methods, with each approach offering distinct advantages. Enzymatic synthesis is often preferred for its high specificity and mild reaction conditions, while chemical synthesis allows for greater scalability. Innovations in green chemistry have further optimized the production process, reducing environmental impact and improving yield. These advancements ensure a steady supply of CAS No. 4546-54-7 to meet the needs of the scientific community.
Looking ahead, the potential of 2-aminopurine riboside in nanotechnology and bioengineering is an exciting area of exploration. Its ability to integrate into nucleic acid nanostructures could pave the way for novel drug delivery systems and biosensors. As interdisciplinary research continues to evolve, 2-AP riboside is poised to play a pivotal role in bridging gaps between chemistry, biology, and engineering. The compound's versatility and adaptability make it a cornerstone of modern scientific inquiry.
In conclusion, 2-aminopurine riboside (CAS No. 4546-54-7) stands as a testament to the ingenuity of nucleoside chemistry. Its diverse applications, from fluorescent labeling to therapeutic development, underscore its value in both academic and industrial settings. As research progresses, the compound's impact on biomedical innovation and scientific discovery will undoubtedly grow, solidifying its place as a vital tool in the life sciences.
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