• 1. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
• 2. Excitonic channels from bio-inspired templated supramolecular assembly of J-aggregate nanowires?
  Daniel Messmer,Stefan Salentinig,Jakob Heier Nanoscale, 2019,11, 6929-6938
• 3. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 4. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 5. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

Introduction to 6-ethynylpyridine-3-carboxylic acid (CAS No. 450368-21-5)

6-ethynylpyridine-3-carboxylic acid, identified by its Chemical Abstracts Service (CAS) number 450368-21-5, is a versatile heterocyclic compound that has garnered significant attention in the field of pharmaceutical and chemical research. This compound belongs to the pyridine family, characterized by a nitrogen-containing aromatic ring, and incorporates an ethynyl substituent at the 6-position and a carboxylic acid group at the 3-position. The unique structural features of 6-ethynylpyridine-3-carboxylic acid make it a valuable intermediate in the synthesis of various bioactive molecules, including potential drug candidates and functional materials.

The ethynylpyridine core structure is particularly interesting due to its ability to participate in diverse chemical reactions, such as Sonogashira coupling, which is widely used in organic synthesis to form carbon-carbon bonds. The presence of the carboxylic acid moiety further enhances its reactivity, allowing for further functionalization via esterification, amidation, or polymerization processes. These properties have positioned 6-ethynylpyridine-3-carboxylic acid as a key building block in medicinal chemistry and materials science.

In recent years, there has been growing interest in 6-ethynylpyridine derivatives due to their potential applications in drug discovery. The pyridine scaffold is a common motif in many approved drugs, owing to its favorable pharmacokinetic properties and ability to interact with biological targets. For instance, studies have shown that pyridine-based compounds can modulate enzyme activity and receptor binding, making them suitable for treating a wide range of diseases, including inflammatory disorders, infectious diseases, and cancers.

One of the most compelling aspects of 6-ethynylpyridine-3-carboxylic acid is its role as a precursor in the synthesis of small-molecule inhibitors. Researchers have leveraged its reactive sites to develop compounds that target specific enzymes or receptors involved in disease pathways. Notably, recent advancements in computational chemistry have enabled the rapid design and optimization of such inhibitors using 6-ethynylpyridine-3-carboxylic acid as a starting point. These computational approaches have accelerated the drug discovery process by predicting molecular interactions and optimizing lead compounds for better efficacy and selectivity.

The carboxylic acid group of 6-ethynylpyridine-3-carboxylic acid also facilitates its incorporation into more complex molecules through conjugation with other functional groups. For example, it can be converted into esters or amides, which are common pharmacophores in drug molecules. Additionally, the ethynyl group provides a site for further modification via cross-coupling reactions, allowing chemists to tailor the structure of their derivatives for specific biological activities.

Another area where 6-ethynylpyridine-3-carboxylic acid has shown promise is in materials science. The compound’s ability to form stable polymers and copolymers has led to investigations into its use as a monomer for advanced materials. These materials could find applications in electronics, coatings, and biodegradable polymers due to their unique electronic and mechanical properties. The versatility of 6-ethynylpyridine derivatives makes them attractive for developing next-generation functional materials with tailored properties.

The synthesis of 6-ethynylpyridine-3-carboxylic acid typically involves multi-step organic transformations starting from readily available pyridine precursors. Advances in synthetic methodologies have improved the efficiency and scalability of these processes, making it more feasible to produce this compound on an industrial scale. Furthermore, green chemistry principles have been increasingly applied to these synthetic routes, reducing waste and energy consumption while maintaining high yields.

In conclusion,6-ethynylpyridine-3-carboxylic acid (CAS No. 450368-21-5) is a multifaceted compound with significant potential in pharmaceuticals and materials science. Its unique structural features enable diverse chemical modifications, making it a valuable tool for drug discovery and material development. As research continues to uncover new applications for this compound,6-ethynylpyridine derivatives are likely to play an increasingly important role in advancing scientific innovation across multiple disciplines.

• 3222-56-8(2-methylpyridine-3-carboxylic acid)
• 100047-52-7(5-Methyl-1H-pyrrole-3-carboxylic acid)
• 2602-36-0(3,5-Pyridinedicarboxylicacid, 2,6-dimethyl-)
• 6542-47-8(6-formylpyridine-3-carboxylic acid)
• 775545-30-7(6-(hydroxymethyl)pyridine-3-carboxylic acid)
• 220882-43-9(6-ethynyl-3-Pyridinecarboxylic acid ethyl ester)
• 216444-00-7(methyl 6-ethynylpyridine-3-carboxylate)
• 5860-71-9(2,6-Dimethylnicotinic acid)
• 3222-47-7(6-Methylnicotinic acid)
• 757903-81-4(5,6-dimethylpyridine-3-carboxylic acid)